Nanouric acid or nanocalcium phosphate as central nidus to induce calcium oxalate stone formation: a high-resolution transmission electron microscopy study on urinary nanocrystallites

Gao, Jie; Xue, Jun-Fa; Xu, Meng; Gui, Bao‐Song; Wang, Fengxin; Ouyang, Jing

doi:10.2147/ijn.s66000

Cited by 10 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6). The results of the distribution form of CaOx crystals by XRD in this study looked similar to the pattern of CaOx crystals analyzed by Gao et al . (2014), Shang et al (2013), and Murray et al (2016).…”

Section: Identification Of Caox Crystalssupporting

confidence: 91%

Calcium oxalate crystals and the optimal growing conditions for Actinidia arguta

Kong,

Goh,

Won

et al. 2024

BioRes

View full text Add to dashboard Cite

The presence, distribution, and morphology of calcium oxalate (CaC2O4, CaOx) crystals were observed in the stunted bodies of Actinidia arguta (A. arguta) vines, and their ability of microorganisms to degrade CaOx crystals was analyzed. Leaves, branches, and roots of stunted A. arguta vines were collected. In the roots, CaOx crystal bundles were distributed in the form of dotted lines. In the branches, CaOx crystal bundles were observed blocking and accumulating in the vessels. In the leaves, CaOx crystal bundles were observed in a net-like entanglement. Therefore, CaOx crystals present in the roots, branches, and leaves hinder the growth. A hydroponic cultivation with different calcium (Ca) concentrations showed that the growth of A. arguta was best at a Ca concentration of 1 cmol+/kg; at a Ca concentration of 2 cmol+/kg, the edges of the leaves began to dry out after 7 days; and at a Ca concentration of 4 cmol+/kg, the entire leaves died within 14 days. From this study, it was concluded that CaOx crystals hindered the growth of A. arguta, and the Acinetobacter calcoaceticus (A. calcoaceticus) strain was effective in degrading CaOx crystals. Therefore, the Ca concentration in the soil of the cultivation site should be managed at less than 2 cmol+/kg.

show abstract

Section: Identification Of Caox Crystalssupporting

confidence: 91%

Calcium oxalate crystals and the optimal growing conditions for Actinidia arguta

Kong,

Goh,

Won

et al. 2024

BioRes

View full text Add to dashboard Cite

show abstract

“…Also, rather than fructose itself, high fructose corn syrup, which is the industry standard sweetener for soda and many foods, has to be considered as a potential risk factor ( 25 , 26 ). Using high-resolution transmission electron microscopy, Gao et al have shown that both nano-uric acid and nano-calcium phosphate may serve as nidus for USD formation ( 27 ).…”

Section: Potential Explanations For the Sex Disparity In Urinary Ston...mentioning

confidence: 99%

In focus: perplexing increase of urinary stone disease in children, adolescent and young adult women and its economic impact

Filler,

Dave,

Ritter

et al. 2023

Front. Med.

View full text Add to dashboard Cite

BackgroundUrinary stone disease (USD) historically has affected older men, but studies suggest recent increases in women, leading to a near identical sex incidence ratio. USD incidence has doubled every 10 years, with disproportionate increases amongst children, adolescent, and young adult (AYA) women. USD stone composition in women is frequently apatite (calcium phosphate), which forms in a higher urine pH, low urinary citrate, and an abundance of urinary uric acid, while men produce more calcium oxalate stones. The reasons for this epidemiological trend are unknown.MethodsThis perspective presents the extent of USD with data from a Canadian Province and a North American institution, explanations for these findings and offers potential solutions to decrease this trend. We describe the economic impact of USD.FindingsThere was a significant increase of 46% in overall surgical interventions for USD in Ontario. The incidence rose from 47.0/100,000 in 2002 to 68.7/100,000 population in 2016. In a single United States institution, the overall USD annual unique patient count rose from 10,612 to 17,706 from 2015 to 2019, and the proportion of women with USD was much higher than expected. In the 10–17-year-old patients, 50.1% were girls; with 57.5% in the 18–34 age group and 53.6% in the 35–44 age group. The roles of obesity, diet, hormones, environmental factors, infections, and antibiotics, as well as the economic impact, are discussed.InterpretationWe confirm the significant increase in USD among women. We offer potential explanations for this sex disparity, including microbiological and pathophysiological aspects. We also outline innovative solutions – that may require steps beyond typical preventive and treatment recommendations.

show abstract

“…Higher serum calcium concentration acts as a promoter in lithogenesis, which directly regulated by the calcium-sensing receptor (CaSR) through different pathways ( 35 ). Similarly, urate and phosphate ions have also been reported to promote heterogeneous nucleation and enhance the attachment of crystals to epitheliums ( 36 , 37 ). Another important promoter of stone formation is urine pH ( 38 ).…”

Section: Physicochemical Mechanism Of Kidney Stone Formationmentioning

confidence: 99%

Recent advances on the mechanisms of kidney stone formation (Review)

et al. 2021

View full text Add to dashboard Cite

Kidney stone disease is one of the oldest diseases known to medicine; however, the mechanisms of stone formation and development remain largely unclear. Over the past decades, a variety of theories and strategies have been developed and utilized in the surgical management of kidney stones, as a result of recent technological advances. Observations from the authors and other research groups suggest that there are five entirely different main mechanisms for kidney stone formation. Urinary supersaturation and crystallization are the driving force for intrarenal crystal precipitation. Randall's plaques are recognized as the origin of calcium oxalate stone formation. Sex hormones may be key players in the development of nephrolithiasis and may thus be potential targets for new drugs to suppress kidney stone formation. The microbiome, including urease-producing bacteria, nanobacteria and intestinal microbiota, is likely to have a profound effect on urological health, both positive and negative, owing to its metabolic output and other contributions. Lastly, the immune response, and particularly macrophage differentiation, play crucial roles in renal calcium oxalate crystal formation. In the present study, the current knowledge for each of these five aspects of kidney stone formation is reviewed. This knowledge may be used to explore novel research opportunities and improve the understanding of the initiation and development of kidney stones for urologists, nephrologists and primary care.

show abstract

Nanouric acid or nanocalcium phosphate as central nidus to induce calcium oxalate stone formation: a high-resolution transmission electron microscopy study on urinary nanocrystallites

Cited by 10 publications

References 31 publications

Calcium oxalate crystals and the optimal growing conditions for Actinidia arguta

Calcium oxalate crystals and the optimal growing conditions for Actinidia arguta

In focus: perplexing increase of urinary stone disease in children, adolescent and young adult women and its economic impact

Recent advances on the mechanisms of kidney stone formation (Review)

Contact Info

Product

Resources

About