Nanozyme enhanced paper-based biochip with a smartphone readout system for rapid detection of cyanotoxins in water

Liu, Jinchuan; Xing, Yunpeng; Xue, Boyuan; Zhou, Xiaoguang

doi:10.1016/j.bios.2022.114099

Cited by 20 publications

(7 citation statements)

References 36 publications

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“…However, the LOQ for the three strategies were slightly different, and the LOQ for MSCC, OSCC and ISCC were 0.05, 0.064 and 0.064 ng/mL for eight MCs, respectively. In comparison with the recent reported methods, the sensitive of the proposed method was quite excellent, which could well meet the requirement for investigating the containment of MCs in freshwater (Liu et al, 2022;Liu et al, 2021). Furthermore, the linearity range, correlation coefficient (r 2 ) of calibration curve, LODs and LOQs for eight MCs under three different approaches are provided in Table 3.…”

Section: Comparing the Methods Validation And Performance Of The Thre...mentioning

confidence: 72%

Novel one-point calibration strategy for high-throughput quantitation of microcystins in freshwater using LC-MS/MS

Zhang

Li²,

Abdallah³

et al. 2023

Science of The Total Environment

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Section: Comparing the Methods Validation And Performance Of The Thre...mentioning

confidence: 72%

Novel one-point calibration strategy for high-throughput quantitation of microcystins in freshwater using LC-MS/MS

Zhang

Li²,

Abdallah³

et al. 2023

Science of The Total Environment

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“…Furthermore, as shown in Figure S11, the biosensor retained 96.8% of the initial current response after 5 weeks of storage in a refrigerator at 4 °C, demonstrating the good long-term stability of the biosensor. The structural tunability and good conductivity of COFs make it attractive to investigate the potential applications for signal amplification or monitoring of multiple contaminants. , …”

Section: Resultsmentioning

confidence: 99%

“…The structural tunability and good conductivity of COFs make it attractive to investigate the potential applications for signal amplification or monitoring of multiple contaminants. 46,47 ■ CONCLUSIONS…”

mentioning

confidence: 99%

2D Conductive Covalent Organic Frameworks with Abundant Carbonyl Groups for Electrochemical Sensing

et al. 2022

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Due to their permanent porosity, robust chemical stability, and tunable structure, covalent organic frameworks (COFs) are very attractive in the application of energy storage, catalysis, sorption, and sensing. However, the very low conductivity of COFs severely restricts their application in electrochemical sensing. Here, an aza-fused π-conjugated COFs with abundant carbonyl groups (COF1) was synthesized and deployed as electrode materials in electrochemical sensing for the first time. The current response of the acetylcholinesterase biosensor based on COF1 increases three times when compared to the electrode without COF1. The effects of carbonyl groups on signal enhancement were proved in depth by a series of characterization and comparison experiments with the prepared COF2 without carbonyl groups. The results demonstrated that exposed carbonyl active sites of COF1 can promote the effective immobilization and bioactivity preserving of enzyme molecules and contribute to the enrichment of analytes. Together with the good conductivity of COF1 derived from a fully extended 2D aromatized π-conjugated system, all of which improve the biosensor performance. The COF1-based biosensor exhibited fast response speed, high sensitivity, good selectivity and practicability, and robust stability for organophosphorus pesticide detection and proved to be a promising tool for the rapid and onsite detection of organophosphorus pesticides in the environment.

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“…The unique variable structure and excellent properties of cMOFs make it interesting to explore the application in the field of nanoenzymes or broader contaminant (biotoxins, antibiotics, etc.) monitoring. − …”

Section: Resultsmentioning

confidence: 99%

Dense Conductive Metal–Organic Frameworks as Robust Electrocatalysts for Biosensing

et al. 2022

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Due to the fascinating properties such as high porosity, large surface areas, and tunable chemical components, metal–organic frameworks (MOFs) have emerged in many fields including catalysis, energy storage, and gas separation. However, the intrinsic electrical insulation of MOFs severely restricts their application in electrochemistry. Here, we synthesize a series of 2D conductive MOFs (cMOFs) through tuning the structure with atomic precision using simple hydrothermal methods. Various electroactive probes are used to reveal the structure–property relationships in 2D cMOFs. Then, we demonstrate the first exploration and implementation of 2D cMOFs toward the construction of electrochemical biosensors. In particular, the biosensor based on Cu3(tetrahydroxy-1,4-quinone)2 [Cu3(THQ)2] displays a remarkably improved electrocatalytic performance at a much lower potential. The mechanism study reveals the essential role of charge-transfer interactions between the dense catalytic sites of Cu3(THQ)2 and analytes. Furthermore, the Cu3(THQ)2-based biosensor demonstrates robust anti-interference capability, good stability, fast response speed, and an ultralow detection limit for paraoxon. These promising results indicate the great potential of cMOFs in biomedical, food safety, and environmental sensing applications.

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Nanozyme enhanced paper-based biochip with a smartphone readout system for rapid detection of cyanotoxins in water

Cited by 20 publications

References 36 publications

Novel one-point calibration strategy for high-throughput quantitation of microcystins in freshwater using LC-MS/MS

Novel one-point calibration strategy for high-throughput quantitation of microcystins in freshwater using LC-MS/MS

2D Conductive Covalent Organic Frameworks with Abundant Carbonyl Groups for Electrochemical Sensing

Dense Conductive Metal–Organic Frameworks as Robust Electrocatalysts for Biosensing

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