Nanozyme-involved biomimetic cascade catalysis for biomedical applications

Cai, Xiaoli; Jiao, Lei; Yan, Hongye; Wu, Yu; Gu, Wenling; Du, Dan; Lin, Yuehe; Zhu, Chengzhou

doi:10.1016/j.mattod.2020.12.005

Cited by 173 publications

(90 citation statements)

References 151 publications

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“…Inspired by this, enzyme-medicated cascade catalysis strategy could be developed for DU microenvironment modulation. However, due to the limitation of the specificity of enzyme-catalyzed reactions as well as high cost and harsh usage condition [ 29 ], enzyme cascade catalysis systems with simple composition that can concurrently address the four DU-related issues remain elusive. Recently, investigation on nanozyme has demonstrated that some nanomaterials (e.g., metal-oxide and carbon-based nanoparticles) possess distinctive pathological conditions-switchable multiple enzyme-like activities, indicating the feasibility of employing one nanozyme to catalyze cascade reactions [ 30 – 33 ].…”

Section: Introductionmentioning

confidence: 99%

pH-switchable nanozyme cascade catalysis: a strategy for spatial–temporal modulation of pathological wound microenvironment to rescue stalled healing in diabetic ulcer

Jia

Wang

et al. 2022

J Nanobiotechnol

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The management of diabetic ulcer (DU) to rescue stalled wound healing remains a paramount clinical challenge due to the spatially and temporally coupled pathological wound microenvironment that features hyperglycemia, biofilm infection, hypoxia and excessive oxidative stress. Here we present a pH-switchable nanozyme cascade catalysis (PNCC) strategy for spatial–temporal modulation of pathological wound microenvironment to rescue stalled healing in DU. The PNCC is demonstrated by employing the nanozyme of clinically approved iron oxide nanoparticles coated with a shell of glucose oxidase (Fe3O4-GOx). The Fe3O4-GOx possesses intrinsic glucose oxidase (GOx), catalase (CAT) and peroxidase (POD)-like activities, and can catalyze pH-switchable glucose-initiated GOx/POD and GOx/CAT cascade reaction in acidic and neutral environment, respectively. Specifically, the GOx/POD cascade reaction generating consecutive fluxes of toxic hydroxyl radical spatially targets the acidic biofilm (pH ~ 5.5), and eradicates biofilm to shorten the inflammatory phase and initiate normal wound healing processes. Furthermore, the GOx/CAT cascade reaction producing consecutive fluxes of oxygen spatially targets the neutral wound tissue, and accelerates the proliferation and remodeling phases of wound healing by addressing the issues of hyperglycemia, hypoxia, and excessive oxidative stress. The shortened inflammatory phase temporally coupled with accelerated proliferation and remodeling phases significantly speed up the normal orchestrated wound-healing cascades. Remarkably, this Fe3O4-GOx-instructed spatial–temporal remodeling of DU microenvironment enables complete re-epithelialization of biofilm-infected wound in diabetic mice within 15 days while minimizing toxicity to normal tissues, exerting great transformation potential in clinical DU management. The proposed PNCC concept offers a new perspective for complex pathological microenvironment remodeling, and may provide a powerful modality for the treatment of microenvironment-associated diseases. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

pH-switchable nanozyme cascade catalysis: a strategy for spatial–temporal modulation of pathological wound microenvironment to rescue stalled healing in diabetic ulcer

Jia

Wang

et al. 2022

J Nanobiotechnol

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“…Therefore, combination therapy involving additional therapeutics is necessary. [ 23–28 ] This however complicates fabrication, encapsulation, delivery, and release processes, making it not practical due to poor reproducibility, reduced effectiveness, high side‐effects, and high cost.…”

Section: Introductionmentioning

confidence: 99%

Fe₃O₄/Ag/Bi₂MoO₆ Photoactivatable Nanozyme for Self‐Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy

et al. 2021

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Catalytic cancer therapy based on nanozymes has recently attracted much interest. However, the types of the current nanozymes are limited and their efficiency is usually compromised and not sustainable in the tumor microenvironment (TME). Therefore, combination therapy involving additional therapeutics is often necessary and the resulting complication may jeopardize the practical feasibility. Herein, an unprecedented “all‐in‐one” Fe3O4/Ag/Bi2MoO6 nanoparticle (FAB NP) is rationally devised to achieve synergistic chemodynamic, photodynamic, photothermal therapy with guidance by magnetic resonance, photoacoustic, and photothermal imaging. Based on its manifold nanozyme activities (mimicking peroxidase, catalase, superoxide dismutase, glutathione oxidase) and photodynamic property, cascaded nanocatalytic reactions are enabled and sustained in TME for outstanding therapeutic outcomes. The working mechanisms underlying the intraparticulate interactions, sustainability, and self‐replenishment arising from the coupling between the nanocatalytic reactions and nanozyme activities are carefully revealed, providing new insights into the design of novel nanozymes for nanocatalytic therapy with high efficiency, good specificity, and low side effects.

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“…It owns efficient mass transfer activities which reduced the intermediate decomposition due to its local production at higher concentrations. [ 1 ] However, strict physiological conditions, selective stability, poor reusability for performing any particular catalytic reactions are the major intrinsic fragility of these naturally occurring enzymes. [ 2 ] In this pursuit, the expansions of nanotechnological advancement have led to the development of nanoscale materials that exactly mimic the “natural‐enzymes” as well as exhibit similar intrinsic properties, popularly known as “nanoenzyme” or “nanoenzyme”.…”

Section: Introductionmentioning

confidence: 99%

Engineered Nanoenzymes with Multifunctional Properties for Next‐Generation Biological and Environmental Applications

Mishra

Lee

Kumar

et al. 2021

Adv Funct Materials

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As a powerful tool, nanoenzyme electrocatalyst broadens the ways to explore bioinspired solutions to the world's energy and environmental concerns. Efforts of fashioning novel nanoenzymes for effective electrode functionalization is generating innovative viable catalysts with high catalytic activity, low cost, high stability and versatility, and ease of production. High chemo‐selectivity and broad functional group tolerance of nanoenzyme with an intrinsic enzyme like activity make them an excellent environmental tool. The catalytic activities and kinetics of nanoenzymes that benefit the development of nanoenzyme‐based energy and environmental technologies by effectual electrode functionalization are discussed in this article. Further, a deep‐insight on recent developments in the state‐of‐art of nanoenzymes either in terms of electrocatalytic redox reactions (viz. oxygen evolution reaction, oxygen reduction reaction, nitrogen reduction reaction and hydrogen evolution reaction) or environmental remediation /treatment of wastewater/or monitoring of a variety of pollutants. The complex interdependence of the physicochemical properties and catalytic characteristics of nanoenzymes are discussed along with the exciting opportunities presented by nanomaterial‐based core structures adorned with nanoparticle active‐sites shell for enhanced catalytic processes. Thus, such modular architecture with multi‐enzymatic potential introduces an immense scope of making its economical scale‐up for multielectron‐fuel or product recovery and multi‐pollutant or pesticide remediation as reality.

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Nanozyme-involved biomimetic cascade catalysis for biomedical applications

Cited by 173 publications

References 151 publications

pH-switchable nanozyme cascade catalysis: a strategy for spatial–temporal modulation of pathological wound microenvironment to rescue stalled healing in diabetic ulcer

pH-switchable nanozyme cascade catalysis: a strategy for spatial–temporal modulation of pathological wound microenvironment to rescue stalled healing in diabetic ulcer

Fe₃O₄/Ag/Bi₂MoO₆ Photoactivatable Nanozyme for Self‐Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy

Engineered Nanoenzymes with Multifunctional Properties for Next‐Generation Biological and Environmental Applications

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Nanozyme-involved biomimetic cascade catalysis for biomedical applications

Cited by 173 publications

References 151 publications

pH-switchable nanozyme cascade catalysis: a strategy for spatial–temporal modulation of pathological wound microenvironment to rescue stalled healing in diabetic ulcer

pH-switchable nanozyme cascade catalysis: a strategy for spatial–temporal modulation of pathological wound microenvironment to rescue stalled healing in diabetic ulcer

Fe3O4/Ag/Bi2MoO6 Photoactivatable Nanozyme for Self‐Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy

Engineered Nanoenzymes with Multifunctional Properties for Next‐Generation Biological and Environmental Applications

Contact Info

Product

Resources

About

Fe₃O₄/Ag/Bi₂MoO₆ Photoactivatable Nanozyme for Self‐Replenishing and Sustainable Cascaded Nanocatalytic Cancer Therapy