Nasal secretions of Neisseria lactamica carriers have an inhibitory effect on Neisseria meningitidis attachment to human oroepithelial cells

Andrade, João Ramos Costa; Marques, Margareth da Cunha; Rosa, Milden Rodrigues de Santa

doi:10.1590/s0074-02761986000400013

Cited by 7 publications

(3 citation statements)

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“…Proteomic, genetic and immunological analyses have indicated considerable similarity between N. lactamica and N. meningitidis antigenicity [7][8][9], and there is evidence that N. lactamica colonization can provide some protection against N. meningitidis infection [10], possibly either by competing for colonization sites or via the induction of cross-reactive antibodies [11]. This has resulted in N. lactamica being studied as a potential vaccine tool for inducing protective immunity against N.…”

Section: N Meningitidis Is Separated Into Serogroups Based On Its Pomentioning

confidence: 99%

Heat shock protein complex vaccines induce antibodies against Neisseria meningitidis via a MyD88-independent mechanism

Han

Cecchini³

et al. 2016

Vaccine

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N. lactamica and N. meningitidis HSPC vaccines both have potential utility for immunising against neisserial meningitis without the requirement for an exogenous adjuvant. The mode of action of these vaccines is highly complex, with HSPCs inducing immune responses via both MyD88-dependent and -independent mechanisms. In particular, these HSPC vaccines induced an antibody response without detectable T cell help.

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Section: N Meningitidis Is Separated Into Serogroups Based On Its Pomentioning

confidence: 99%

Heat shock protein complex vaccines induce antibodies against Neisseria meningitidis via a MyD88-independent mechanism

Han

Cecchini³

et al. 2016

Vaccine

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“…Furthermore, nasal secretions of volunteers colonized by N. lactamica were shown to impair the attachment of meningococci to oroepithelial cells [19]. In our study, N. lactamica carriage was twofold higher than N. meningitidis carriage.…”

Section: Discussionmentioning

confidence: 41%

Prevalence of Neisseria meningitidis carriage: a small-scale survey in Istanbul, Turkey

Kadayıfçı

Merdan

Soysal

et al. 2016

J Infect Dev Ctries

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Introduction: The human nasopharynx is the main reservoir of Neisseria meningitidis, and asymptomatic carriage is common. N. meningitidis one of the common causes of bacterial meningitis in Turkey, especially after the implementation of the national immunization program that includes conjugated pneumococcal and Haemophilus influenzae type b vaccines. The purpose of this study was to evaluate the prevalence of meningococcal carriage and determine the leading serogroup, which may help authorities to adapt appropriate meningococal vaccine into the national immunization programme. Methodology: The prevalence of oropharyngeal carriage of N. meningitidis in 1,000 healthy subjects, 0-79 years of age, was investigated. Oropharyngeal swabs were collected during an 18-month period. Samples obtained were inoculated onto Thayer-Martin agar. The API-NH test and VITEK-MS system were used for identification of colonies. Multiplex real-time polymerase chain reaction assay was used to determine serogroups with serogroup-specific genes. Results: N. meningitidis was isolated from 6 of 1,000 subjects (0.6%). Meningoccocal carriers were between 21 and 40 years of age. All isolates were serogrouped as B, except one that did not survive on subculture. N. lactamica was isolated from 13 of 1,000 subjects (1.3%). Conclusions: Carriage rate of meningococci in our study was relatively low. However, we detected that serogroup B was the leading strain in meningococcal carriage in Istanbul; choosing an appropriate meningococcal vaccine containing serogroup B should therefore be considered. High absolute humidity throughout the year in Istanbul may explain the low prevalence of carriage in our study. This should be verified with a multicenter national survey.

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“…Foi desenvolvido um modelo matemático da influencia de carreadores na infecção e doença, e o papel de N. lactamica como um imunógeno natural contra a infecção meningocócica sintomática e assintomática e os dados foram consistentes e fieis (Coen et al, 2000). Uma demonstração funcional da imunidade antimeningocócica induzida em portadores de N. lactamica foi a observação que as secreções nasais dos portadores de N. lactamica tem um efeito inibitório sobre a adesão de N. meningitidis nas células epiteliais orais em humanos (Andrade et al, 1986). Como preferencialmente o uso de conservante não está incluído, o processo de esterilização usando filtro foi desenvolvido.…”

Section: -Materiais E Métodosunclassified

Imunização Nasal Em Coelhos Com Neisseria Lactamica: Importância Dos Antígenos De Reatividade Cruzada

Tunes¹

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anticorpos produzidos pelos coelhos imunizados intranasalmente com N. meningitidis. Anticorpos IgG de alta avidez foram produzidos, embora não tenha sido determinada uma significativa correlação entre atividade bactericida e a indução de anticorpos IgG de alta avidez, principalmente nos coelhos imunizados com N. lactamica. A imunização RESUMO intranasal usando whole cells de N. lactamica foi adequada para sensibilizar eficientemente o sistema imune de mucosa no modelo coelho.

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Nasal secretions of Neisseria lactamica carriers have an inhibitory effect on Neisseria meningitidis attachment to human oroepithelial cells

Cited by 7 publications

References 0 publications

Heat shock protein complex vaccines induce antibodies against Neisseria meningitidis via a MyD88-independent mechanism

Heat shock protein complex vaccines induce antibodies against Neisseria meningitidis via a MyD88-independent mechanism

Prevalence of Neisseria meningitidis carriage: a small-scale survey in Istanbul, Turkey

Imunização Nasal Em Coelhos Com Neisseria Lactamica: Importância Dos Antígenos De Reatividade Cruzada

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