Cancer leaves important consequences in the shape, function and esthetics of the patient, especially when it is cancer of the oral cavity or upper aero-digestive tract. Although reconstruction with local and microvascular flaps is sometimes a viable option, maxillofacial rehabilitation with osseointegrated implants is a well-reported treatment alternative with a high success rate. The main advantages in this modality of rehabilitation are the decrease in biological and economic costs, simplifying the management of these defects by reducing surgical intervention, hospitalization time, postoperative morbidity and treatment time. There are several classification systems; however, there is no classification system that has accurately described the maxillofacial defect under a surgical, prosthetic and reconstructive approach with osseointegrated implants. The purpose of this study is to guide professionals in decision-making for maxillofacial rehabilitation using osseointegrated implants located in the anatomical buttresses of the maxillofacial region.