Nasopharyngeal carcinoma in the second decade of life.

Vita, Hernan Castro; Mendiondo, Oscar A.; Shaw, Daigee; Jelden, Gwynn; Rene, JB; Frias, Z; Someren, Ayten

doi:10.1148/radiology.148.1.6856845

Cited by 24 publications

(2 citation statements)

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“…Sham et al did not find a significant difference in survival between adult and young NPC in Hong Kong, classified by Ho's system 13 . Other early series report five‐year disease‐free survival rates of 30–60%, similar to adults 9,14 . In the paper on our general population NPC, the five‐year actuarial survival rates were stage III 60% and stage IV 32% 2 .…”

Section: Discussionmentioning

confidence: 61%

Nasopharyngeal Carcinoma in Young Patients

Lim

Goh

Loong

et al. 2003

Int J Clinical Practice

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SUMMARYNasopharyngeal carcinoma (NPC) is rare in under 20‐year‐olds. Early diagnosis greatly improves survival. A retrospective review of 12 young NPC patients (seven males, five females, mean age 16 years) was performed to identify differing patient and tumour characteristics from adult NPC. Seventy‐five per cent presented with neck lumps and 25% with headache. None had a family history of NPC or epistaxis. One patient had early stage NPC, and 11 had late stage NPC. Three late stage patients who received chemoradiotherapy had better clinical outcomes than six late stage patients receiving only radiotherapy. There were six deaths, five bony recurrences and one postnasal space recurrence. The 11 late stage patients' five‐year actuarial survival was only 29%. Headache is an important symptom for young NPC. Late stage presentation and distant recurrences are also more common, supporting an increased role of chemotherapy.

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Section: Discussionmentioning

confidence: 61%

Nasopharyngeal Carcinoma in Young Patients

Lim

Goh

Loong

et al. 2003

Int J Clinical Practice

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“…Mit zunehmender Strahlendosis wird eine Verbesserung der Prognose erreicht. Es besteht eine eindeutige Korrelation zwischenStrahlendosis und Tumoransprechen (18, 19, 39,42). Mit einer Strahlendosis von > 60 Gy erreichen 70% der Patienten in niedrigen Stadien (Tl-T2) eine 5-Jahre-rezidivfreie Überlebenszeit, im Vergleich dazu sind es in den hohen Stadien T3 und T4 nur 20% (37).…”

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Kombinierte Behandlung des Nasopharynxkarzinoms bei Kindern und Jugendlichen - Konzept einer Studie

Mertens

Lassay²,

Heimann³

1993

Klin Padiatr

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Nasopharyngeal carcinomas (NPCs) are malignant tumors which exhibit a wide disparity in their age, racial, and geographic incidence. In parts of Africa NPCs account for 10% to 20% of childhood malignancies. In USA and Europe, the NCP is an uncommon tumor (0.2% of all malignancies) and amounts to only 1% to 2% of childhood malignancies. Etiology and pathogenesis are closely related to an infection with Epstein-Barr Virus (EBV) and the EBV genome was detected in tumor tissues. Children with NPC differ from their adult counterparts in having a closer association with Epstein-Barr-Virus-Infections. The classical lymphoepithelial carcinomas (Cologne type II-type III) have been found in young patients. Clinically, the disease is aggressive, characterised by frequent metastases in bone and lung. These carcinomas are associated with significantly elevated anti-EBV-titers. The prognosis of children with advanced NPC is poor with a 5-year survival rate between 20-30%. Radiotherapy is the treatment of choice in NPC which has provided an improvement in local tumor control in recent years. Human fibroblast interferon is an active agent in recurrent NPC. Seven children have been treated with IFN-beta, (6 with human und 1 with recombinant IFN-beta) as an adjuvant therapy in doses of 10(5) U/kg body weight three times a week for half a year. All patients received radiotherapy to primary site and had advanced stages (III-IV) at presentation. The patients' age ranged from 14-19 years at diagnosis. Six are still in CR (RFS are 10, 8, 8, 7, 6 and 1.5 years) and one patient relapsed after 18 months.(ABSTRACT TRUNCATED AT 250 WORDS)

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Nasopharyngeal carcinoma in childhood and adolescence

Serin

Erkal

Elhan

et al. 1998

Med. Pediatr. Oncol.

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Background This study reviews the authors' experience from 1979 through 1996 in the management and outcome of 56 patients with nasopharyngeal carcinoma who were under 20 years of age. Procedure There were 33 males and 23 females, their ages ranging from 7 to 19 years (median: 16 years). Forty patients had World Health Organization type III carcinomas, 16 had T4 tumors, 41 had metastatic cervical lymph nodes, and 50 were at stage III or stage IV. Thirty‐two patients were treated with radiation therapy alone and 24 with the addition of chemotherapy. Cumulative radiation dose to the primary tumor ranged from 18 to 70 Gy (median: 66 Gy) and radiation dose to metastatic cervical lymph nodes ranged from 18 to 70 Gy (median: 66 Gy). Results Follow‐up ranged from 0.1 to 16.8 years (mean: 9 years). Locoregional tumoral complete response was achieved in 49 patients. Locoregional tumoral failure was observed in 12 patients and systemic failure in 11. Overall, locoregional failure‐free, metastases‐free, and disease‐free survival rates at 5 years were 49%, 62%, 79%, and 47%, respectively, for the entire group of patients, 42%, 61%, 72%, and 42%, respectively, for patients treated with radiation therapy alone, and 58%, 63%, 87%, and 54%, respectively, for patients treated with the addition of chemotherapy. Advanced T‐stage and lower radiation doses worsened locoregional failure‐free survival, whereas advanced N‐stage and exclusion of chemotherapy worsened metastases‐free survival. Conclusions In children and adolescents with nasopharyngeal carcinoma, radiation therapy alone results in an improved locoregional tumoral response rate and a reduced locoregional tumoral failure rate at higher radiation doses, while the addition of chemotherapy results in a reduced systemic failure rate. Med. Pediatr. Oncol. 31:498–505, 1998. © 1998 Wiley‐Liss, Inc.

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Nasopharyngeal carcinoma in the second decade of life.

Cited by 24 publications

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Nasopharyngeal Carcinoma in Young Patients

Nasopharyngeal Carcinoma in Young Patients

Kombinierte Behandlung des Nasopharynxkarzinoms bei Kindern und Jugendlichen - Konzept einer Studie

Nasopharyngeal carcinoma in childhood and adolescence

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