Nasopharyngeal Carcinoma With Orbital Involvement

Lee, Kelvin Y. C.; Seah, Lay-Leng; Tow, Sharon; Cullen, J F; Fong, K. Y.

doi:10.1097/iop.0b013e318171a629

Cited by 23 publications

(21 citation statements)

References 6 publications

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“…However, one should differentiate orbital metastasis from orbital extension of NPC. Orbital extension often occurs via the pterygopalatine fossa and inferior orbital fissure, or sometimes through the ethmoid and sphenoid sinuses [15].…”

Section: Discussionmentioning

confidence: 99%

Metastatic orbital tumors in southern China during an 18-year period

Yan

Gao

2011

Graefes Arch Clin Exp Ophthalmol

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Section: Discussionmentioning

confidence: 99%

Metastatic orbital tumors in southern China during an 18-year period

Yan

Gao

2011

Graefes Arch Clin Exp Ophthalmol

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“…To the best of our knowledge, only three case series in the literature have shown cases with ophthalmic complaints as the initial signs of NPC. [ 3 4 5 ] The rest were all individual case reports with unique presentations.…”

Section: Discussionmentioning

confidence: 99%

“…[ 2 ] In our literature review, we only found three case series that reported ophthalmic manifestations of NPC tumors before or in association with NPC initial presentation. [ 3 4 5 ] To the best of our knowledge, there were no local similar reports describing ophthalmic complaints as an initial presentation of NPC in our region. In this case series, we describe patients who presented to our ophthalmic practice before being diagnosed with NPC to highlight the most common possible ophthalmic manifestations of NPC tumors that should attract the attention of general ophthalmologists and ocular pathologists to this diagnosis.…”

Section: Introductionmentioning

confidence: 93%

Nasopharyngeal carcinoma (NPC) in the ophthalmic practice

Alkatan

Alrashed

Alarfaj

et al. 2021

Saudi Journal of Ophthalmology

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PURPOSE: Nasopharyngeal carcinoma (NPC) is an aggressive malignant tumor that arises from the nasopharyngeal epithelial lining. Most patients with NPC present with a neck mass or cranial nerve palsy. It is infrequent for patients with NPC to present to an ophthalmologist initially with ophthalmic complaints and absence of prior diagnosis of NPC. We are reporting a series of six NPC cases that presented solely with ophthalmic complaints, to attract the attention of ophthalmologist to such a serious neoplasm. METHODS: A retrospective observational study of all consecutive patients diagnosed with NPC based on their initial ophthalmic presentation with no prior diagnosis of this neoplasm. Patients presented for the first time to two tertiary eye hospitals. Data were collected by the chart review for demographics, clinical presentation, radiological imaging, treatment regimen, and follow-up. Histopathological review of their tissue specimens was conducted by two pathologists. RESULTS: We had six patients who presented for the first time to our ophthalmic service complaining mostly of limitation of extraocular muscle motility with or without diplopia (4/6), orbital or facial pain (2/6), and disturbance in vision (2/6). The age ranged from 35 to 92 years with a mean of 58 years. A male predominance was observed with male-to-female ratio of 5:1. The cases are described along with their imaging and histopathological findings. Relevant literature review was also presented. Most of our patients (5/6) received combination of radiotherapy and chemotherapy. One patient refused treatment and 2 eventually passed away after 7 months. CONCLUSION: Ophthalmologists may play a major role in diagnosing such patients accurately and referring them for early management and better prognosis.

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“…In a series reported by Heng et al , only 2.6 per cent of non-disseminated nasopharyngeal carcinoma cases had orbital involvement, and this was reported mainly in cases of recurrent nasopharyngeal carcinoma 2 . Kelvin et al described nine cases of nasopharyngeal carcinoma with orbital involvement; eight of these nine cases had previously been treated for nasopharyngeal carcinoma, with subsequent new orbital relapse 3 …”

Section: Discussionmentioning

confidence: 99%