Nasopharyngeal T-cell Monomorphic Posttransplant Lymphoproliferative Disorders and Combined IgA Nephropathy and Membranous Glomerulonephritis in a Patient with Renal Transplantation: A Case Report with Literature Review

Kfoury, Hala; Alghonaim, Mohammed; Alsuwaida, Abdulkareem; Zaidi, Shaesta Naseem; Arafah, Maria

doi:10.1016/j.transproceed.2010.09.162

Cited by 11 publications

(9 citation statements)

References 18 publications

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“…In our cohort, monomorphic PTLD were all diffuse large B, plasmablastic or plasmacytoid cell phenotypes. In other studies, in addition to B‐PTLD, T‐cell phenotypes have also been reported, but no CD30+/CD15+ Hodgkin lymphoma types . In general, both T‐PTLD and Hodgkin PTLD are rare PTLD subtypes, while high‐grade B‐PTLD comprise ~80–90% of all monomorphic lesions .…”

Section: Discussionmentioning

confidence: 92%

“…To increase the number of cases, we combined our own data with data from the literature. From the literature, we identified a total of 61 reports on monomorphic B‐PTLD ( n = 34) , T‐PTLD ( n = 7) and polymorphic PTLD ( n = 20) with sinonasal and/or oro‐/nasopharyngeal manifestation. Therefore, including our cases, a total of 140 cases were evaluated (Table ).…”

Section: Resultsmentioning

confidence: 99%

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Post-transplant lymphoproliferative disorders with naso- and oropharyngeal manifestation

et al. 2015

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SummaryThe nasopharyngeal/oropharyngeal lymphatic tissues represent the anatomical site of Epstein-Barr virus (EBV) entry. Post-transplant lymphoproliferative disorders (PTLD) are often associated with EBV, but little is known about the characteristics of nasopharyngeal/oropharyngeal mass-forming PTLD. Retrospective evaluation of our own PTLD database (n = 79) and the PubMed â database (n = 61) has been performed. Sinonasal/oro-/nasopharyngeal lymphatic masses were early lesions (n = 54/140, 38.5%), polymorphic PTLD (n = 32/140, 23%), monomorphic B-PTLD (n = 47/140, 33.5%) and T-PTLD (n = 7/140, 5%). Onefourth of lesions manifested as masses in the Waldeyer's ring, and in two-thirds of cases, swelling of tonsils was related to manifestation of benign early lesions. Tonsil infiltration by polymorphic PTLD and monomorphic PTLD was present in one-third of cases. Extratonsillar masses were mainly monomorphic PTLD. Meta-analysis of our data in combination with previously published data revealed that lung transplantation and young patients are at a higher risk for earlier manifestation of monomorphic PTLD. Therapy is similar to PTLD therapy strategies, in general reduced immunosuppression and chemotherapy for polymorphic and monomorphic PTLD, and diagnostic and therapeutic surgical gross tumour resection of tonsillar/adenoid lesions. In summary, it is relevant for the clinical differential diagnosis that oro-/nasopharyngeal aggressive PTLD manifested in~30% as tonsillar masses and >90% at extratonsillar sites.

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Section: Discussionmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Post-transplant lymphoproliferative disorders with naso- and oropharyngeal manifestation

et al. 2015

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“…IgAN often recurs in renal allografts in IgAN patients, while MN is the most common de novo glomerulonephritis occurring in renal allografts. Thus, the coexistence of MN and IgAN may be more likely to occur in renal allografts in IgAN patients [3][4][5]. HBs antigenemia was also detected in 3 out of 23 cases of coexisting MN and IgAN, suggesting the pathogenetic role of HBs antigen-associated immune complexes [6].…”

Section: Discussionmentioning

confidence: 97%

“…To date, 23 cases of coexisting MN and IgAN have been reported in the English literature; six were in renal allografts while remainder were in native kidneys [3][4][5][6]. Of these, pediatric cases are still rare.…”

Section: Discussionmentioning

confidence: 99%

“…IgA nephropathy (IgAN) is the most common primary glomerulonephritis among the pediatric population and is characterized by dominant or codominant IgA mesangial deposits [2]. Although cases of coexisting MN and IgAN have been reported previously in adults [3][4][5], it is very rare in children [6]. We herein present a case of a 14-year-old boy with asymptomatic hematuria/proteinuria who was diagnosed with coexisting MN and IgAN.…”

Section: Introductionmentioning

confidence: 93%

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Coexisting Membranous Nephropathy and IgA Nephropathy

Nishida

Kato

Hamaoka

2015

Fetal and Pediatric Pathology

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We herein present a case of a 14-year-old boy with the histological features of coexisting membranous nephropathy (MN) and IgA nephropathy (IgAN). Asymptomatic hematuria/proteinuria was initially detected in school urinary screening, with treatments including oral corticosteroids leading to complete remission. Cases of coexisting MN and IgAN are very rare among the pediatric population; however, the overlap of these two nephropathies does not always imply a deleterious clinical outcome in pediatric cases.

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