National burden estimates of hospitalisations for acute lower respiratory infections due to respiratory syncytial virus in young children in 2019 among 58 countries: a modelling study

Li, You; Johnson, Emily K.; Shi, Ting; Campbell, Harry; Chaves, Sandra S.; Commaille-Chapus, Catherine; Dighero, Izzie; James, Spencer L.; Mahé, Cédric; Ooi, Yujing; Paget, John; Pomeren, Tayma van; Viboud, Cécile; Nair, Harish

doi:10.1016/s2213-2600(20)30322-2

Cited by 82 publications

(65 citation statements)

References 23 publications

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“…It has been shown that the cost of inpatient treatment due to RSV is higher than the total health expenditures per capita in developed countries. (10,11) In our study, it was shown that RSV significantly increases the cost both alone and in coinfections. In addition, RSV is the most important viral agent that increases the cost not only in risky infants but also in children under five years of age.…”

Section: Accepted Manuscriptmentioning

confidence: 55%

Comparison of Clinical, Demographic Features, and Costs in Respiratory Syncytial Virus, Rhinovirus, and Viral Co-infections in Children Hospitalized with Viral Infections of the Lower Respiratory Tract

et al. 2022

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Viruses are the most common cause of lower respiratory tract infections (LRTIs) in children.Our study aims to shed light on co-infections by comparing with the most common single agents, Respiratory syncytial virus (RSV) and Rhinovirus (RV), in terms of epidemiological, clinical, laboratory and cost. This retrospective study included infants under the age of five, hospitalized with a diagnosis of LRTI with RSV, RV or co-infection were analyzed. The study group consisted of 199 children, RSV was detected in 116 patients (58,3%), RV in 46 (23,1%) and co-infections in 37 (18,6%). The average age of RV was higher (P = 0.006) and the lenght of hospital stay of RSVinfected patients was longer (P = 0.03) than other agents. There was no significant difference between the groups in terms of oxygen need, intensive care unit admission, intubation, and development of complications. The cost was found to be significantly higher in the RSV group (P=0.02). Viral coinfections, RSV and RV constitute an important part of the etiology in patients under five years of age and co-infections do not cause more severe clinical findings compared to single viral agents.Moreover cost was found to be significantly higher in patients with RSV.

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Section: Accepted Manuscriptmentioning

confidence: 55%

Comparison of Clinical, Demographic Features, and Costs in Respiratory Syncytial Virus, Rhinovirus, and Viral Co-infections in Children Hospitalized with Viral Infections of the Lower Respiratory Tract

et al. 2022

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“…However, the 2019/20 incidence of VS-LRTI is in the range of expected values for a mean RSV season. This limitation is thus unlikely to have influenced the results [ 10 , 14 ]. Finally, we did not investigate climate-driven factors such as specific humidity, precipitation, and temperature that might have played a role in shaping this late RSV dynamic [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Characteristics of the delayed respiratory syncytial virus epidemic, 2020/2021, Rhône Loire, France

et al. 2021

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The Rhône-Loire metropolitan areas’ 2020/21 respiratory syncytial virus (RSV) epidemic was delayed following the implementation of non-pharmaceutical interventions (NPI), compared with previous seasons. Very severe lower respiratory tract infection incidence among infants ≤ 3 months decreased twofold, the proportion of cases among children aged > 3 months to 5 years increased, and cases among adults > 65 years were markedly reduced. NPI appeared to reduce the RSV burden among at-risk groups, and should be promoted to minimise impact of future RSV outbreaks.

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“…The weighted average of available country-specific rates and the sum of weighted uncertainties in each region was extrapolated to yield the number of ALRI hospital admissions in the region. 11 Global results were calculated as the sum of estimates by age group and World Bank income regions. We also reported estimates by UNICEF regions where data were available.…”

Section: Systematic Review and Assessment Of Risk Of Biasmentioning

confidence: 99%

Global hospital admissions and in-hospital mortality associated with all-cause and virus-specific acute lower respiratory infections in children and adolescents aged 5–19 years between 1995 and 2019: a systematic review and modelling study

Wang

Mei

et al. 2021

BMJ Glob Health

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IntroductionThe burden of acute lower respiratory infections (ALRI), and common viral ALRI aetiologies among 5–19 years are less well understood. We conducted a systematic review to estimate global burden of all-cause and virus-specific ALRI in 5–19 years.MethodsWe searched eight databases and Google for studies published between 1995 and 2019 and reporting data on burden of all-cause ALRI or ALRI associated with influenza virus, respiratory syncytial virus, human metapneumovirus and human parainfluenza virus. We assessed risk of bias using a modified Newcastle-Ottawa Scale. We developed an analytical framework to report burden by age, country and region when there were sufficient data (all-cause and influenza-associated ALRI hospital admissions). We estimated all-cause ALRI in-hospital deaths and hospital admissions for ALRI associated with respiratory syncytial virus, human metapneumovirus and human parainfluenza virus by region.ResultsGlobally, an estimated 5.5 million (UR 4.0–7.8) all-cause ALRI hospital admissions occurred annually between 1995 and 2019 in 5–19 year olds, causing 87 900 (UR 40 300–180 600) in-hospital deaths annually. Influenza virus and respiratory syncytial virus were associated with 1 078 600 (UR 4 56 500–2 650 200) and 231 800 (UR 142 700–3 73 200) ALRI hospital admissions in 5–19 years. Human metapneumovirus and human parainfluenza virus were associated with 105 500 (UR 57 200–181 700) and 124 800 (UR 67 300–228 500) ALRI hospital admissions in 5–14 years. About 55% of all-cause ALRI hospital admissions and 63% of influenza-associated ALRI hospital admissions occurred in those 5–9 years globally. All-cause and influenza-associated ALRI hospital admission rates were highest in upper-middle income countries, Asia-Pacific region and the Latin America and Caribbean region.ConclusionIncidence and mortality data for all-cause and virus-specific ALRI in 5–19 year olds are scarce. The lack of data in low-income countries and Eastern Europe and Central Asia, South Asia, and West and Central Africa warrants efforts to improve the development and access to healthcare services, diagnostic capacity, and data reporting.

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National burden estimates of hospitalisations for acute lower respiratory infections due to respiratory syncytial virus in young children in 2019 among 58 countries: a modelling study

Cited by 82 publications

References 23 publications

Comparison of Clinical, Demographic Features, and Costs in Respiratory Syncytial Virus, Rhinovirus, and Viral Co-infections in Children Hospitalized with Viral Infections of the Lower Respiratory Tract

Comparison of Clinical, Demographic Features, and Costs in Respiratory Syncytial Virus, Rhinovirus, and Viral Co-infections in Children Hospitalized with Viral Infections of the Lower Respiratory Tract

Characteristics of the delayed respiratory syncytial virus epidemic, 2020/2021, Rhône Loire, France

Global hospital admissions and in-hospital mortality associated with all-cause and virus-specific acute lower respiratory infections in children and adolescents aged 5–19 years between 1995 and 2019: a systematic review and modelling study

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