National statistics about resection of the primary tumor in asymptomatic patients with Stage IV colorectal cancer and unresectable metastases. Need for improvement in data collection. A systematic review with meta-analysis

Sterpetti, Antonio V.; U, Costi; D'Ermo, Giuseppe

doi:10.1016/j.suronc.2019.12.004

Cited by 17 publications

(17 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide, and because of its increasing incidence in younger populations coinciding with a decreasing incidence in older individuals, the CRC patient population as a whole is rapidly shifting toward a younger demographic (Siegel et al, 2020). CRC is generally asymptomatic until it reaches an advanced stage, and more than 25% of CRC patients have lymph node or even distant metastasis at initial diagnosis (stage IV) (Tauriello et al, 2017;Sterpetti et al, 2020). Metastasis is the main cause of death in patients with CRC (Van Cutsem et al, 2018;Hafizi et al, 2019), among which liver and lung metastasis account for approximately 60 and 30% of these deaths, respectively (Wang et al, 2018;Li et al, 2019;Kasprzak and Adamek, 2020).…”

Section: Introductionmentioning

confidence: 99%

Transgelins: Cytoskeletal Associated Proteins Implicated in the Metastasis of Colorectal Cancer

Zhang

et al. 2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Transgelins, including transgelin-1 (T-1), transgelin-2 (T-2), and transgelin-3 (T-3), are a family of actin-binding proteins (ABPs) that can alter the structure and morphology of the cytoskeleton. These proteins function by regulating migration, proliferation and apoptosis in many different cancers. Several studies have shown that in various types of tumor cells, including colorectal cancer (CRC) cells, and in the tumor microenvironment, the expression and biological effects of transgelins are diverse and may transform during tumor progression. Previous researches have demonstrated that transgelin levels are positively correlated with metastasis in CRC, and down-regulating their expression can inhibit this process. In advanced disease, T-1 is a tumor activator with increasing expression, and T-2 expression increases with the progression of CRC. Finally, T-3 is only expressed in neurons and is not associated with CRC. This evidence suggests that T-1 and T-2 are potential biomarkers and therapeutic targets for CRC metastasis.

show abstract

Section: Introductionmentioning

confidence: 99%

Transgelins: Cytoskeletal Associated Proteins Implicated in the Metastasis of Colorectal Cancer

Zhang

et al. 2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…This finding was consistent with that reported in previous studies, which indicated that PTR was associated with prolonged survival. 9 , 19 - 22 A population-based and propensity-score-adjusted trend analysis, including 37 793 patients with metastatic colorectal cancer, concluded that palliative PTR was associated with improved OS and cancer-specific survival. 20 Another recent study based on the ARCAD database also identified PTR as a prognostic factor, with patients receiving PTR having better survival compared with those who did not.…”

Section: Discussionmentioning

confidence: 99%

Impact of Upfront Chemotherapy on the Effect of Primary Tumour Resection for Asymptomatic Synchronous Colorectal Cancer With Unresectable Metastases: A Propensity-Score-Matched Cohort Analysis

Huang

Wei

Chen

et al. 2022

Clin Med Insights Oncol

View full text Add to dashboard Cite

Background: It is controversial whether primary tumour resection (PTR) and the sequencing of chemotherapy and PTR are associated with the survival of patients with incurable stage IV colorectal cancer. This study aimed to explore the effects of PTR and the sequencing of chemotherapy and PTR on asymptomatic colorectal cancer with synchronous unresectable metastases (asmCRC). Patients and Methods: Patients with asmCRC were retrospectively identified from a single centre and categorised into 3 groups: PTR followed by chemotherapy (POC), upfront chemotherapy followed by PTR (UFC), and palliative chemotherapy (PC). The primary end points included median overall survival (OS) and progression-free survival (PFS). Clinical features were analysed using χ2 test, while survival curves were generated using the Kaplan-Meier test. Propensity-score matching (PSM) was performed when comparing survival between POC and UFC groups. Results: From 2008 to 2014, 255 patients were identified and included into the POC (n = 101), UFC (n = 40), and PC (n = 114) groups. The UFC and POC groups had significantly better median OS compared with the PC group (40.7 vs 16.3 months, P < .0001; 39.7 vs 16.3 months, P < .0001). Before PSM, the UFC group had better median PFS than the POC and PC groups (18.5 vs 9.7 months, P = .038; 18.5 vs 6.1 months, P < .0001). After PSM, UFC has better PFS than POC ( P = .038). And the UFC group did not have higher postoperative or preoperative morbidity compared with the POC group ( P = .235). Conclusions: Primary tumour resection could improve the survival of patients with asmCRC. Compared with POC or PC, UFC was associated with a better median PFS without significantly increasing preoperative or postoperative morbidity.

show abstract

“…Colorectal cancer is the third most common cause of cancer in men and women in the world [ 23 ]. To reduce the harm of colorectal cancer, prevention strategies such as eating habits improvement, high-quality screening and diagnosis have been suggested [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA SNHG10 promotes colorectal cancer cells malignant progression by targeting miR-3690

et al. 2021

View full text Add to dashboard Cite

Long noncoding RNA small nucleolar RNA host gene 10 (SNHG10) has been suggested to function as tumor promoter in various human cancer types. Herein, the role of SNHG10 in colorectal cancer (CRC) was explored. Expression levels of genes in colorectal cancer tissues and cell lines were detected by Starbase and reverse transcription quantitative PCR (RT-qPCR) Cell Counting Kit-8 (CCK-8), the BrdU incorporation assay and Transwell assays were explored to study the function of SNHG10 in HCT116 and DXH-1 cells. In addition, the interaction of SNHG10 and miR-3690 was analyzed by dual-luciferase reporter assays. SNHG10 had a high expression level in CRC tissues and cell lines. Meanwhile, knockdown of SNHG10 reduced cell viability, inhibited cell proliferation and decreased cell migration and invasion. Moreover, bioinformatics analysis revealed that one potential target gene of SNHG10 was miR-3690. Dual-luciferase reporter assay confirmed that miR-3690 directly targeted SNHG10. Importantly, SNHG10 could decrease the expression of miR-3690 in HCT116 and DXH-1 cells. More importantly, the silencing of miR-3690 reversed the effect of the SNHG10 knockdown on the cell viability, proliferation, migration and invasion of HCT116 and DXH-1 cells. The present results demonstrated that SNHG10 promotes colorectal cancer cells the malignant progression by targeting miR-3690.

show abstract

National statistics about resection of the primary tumor in asymptomatic patients with Stage IV colorectal cancer and unresectable metastases. Need for improvement in data collection. A systematic review with meta-analysis

Cited by 17 publications

References 57 publications

Transgelins: Cytoskeletal Associated Proteins Implicated in the Metastasis of Colorectal Cancer

Transgelins: Cytoskeletal Associated Proteins Implicated in the Metastasis of Colorectal Cancer

Impact of Upfront Chemotherapy on the Effect of Primary Tumour Resection for Asymptomatic Synchronous Colorectal Cancer With Unresectable Metastases: A Propensity-Score-Matched Cohort Analysis

Long noncoding RNA SNHG10 promotes colorectal cancer cells malignant progression by targeting miR-3690

Contact Info

Product

Resources

About