Native collagen application in clinical practice for chronic wounds treatment

Silina, Ekaterina; Stupin, Victor; Zolotareva, L.S.; Комаров, А Н

doi:10.17116/hirurgia2017978-84

Cited by 8 publications

(6 citation statements)

References 8 publications

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“…Manufacturing of biomaterials based on native collagen allows complete preservation of its natural structure and removal of cell elements carrying specific cellular markers (melanocytes, macrophages, and lymphocytes) as well as portions of blood vessels and hair follicles that ensure low antigenicity of collagen devices (43).…”

Section: Collagenbased Medical Devices and Productsmentioning

confidence: 99%

“…Finally, the native exogenous collagen gradually resorbs and is substituted by the recipient's own connective tissue. Therefore, native collagen is a kind of "stencil" for the formation of the recipient's own tissue, which makes it far more superior compared to products containing cleaved collagen (29,43,44).…”

Section: Collagenbased Medical Devices and Productsmentioning

confidence: 99%

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Biological Mechanisms of Chronic Wound and Diabetic Foot Healing: The Role of Collagen

Stupin

Gabitov

Sinel’nikova

et al. 2018

Serbian Journal of Experimental and Clinical Research

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The treatment of chronic wounds is a continuously developing research focus. The problems of excessive mechanical forces, infection, inflammation, reduced production of growth factors, and lack of collagen will affect the results of treatment. The purpose of this study was to analysse the elements that lead to long-term non-healing of chronic wounds and trophic ulcers, including diabetic foot syndrome, by determining the optimal treatment algorithm. The paper presents an analysis of the world literature on the etiopathogenesis and principles of chronic wound treatment in diabetic foot syndrome. The epidemiology of chronic wounds of different genesis is presented. The issues of physiological and metabolic disorders in chronic ulcers affecting the process of wound healing are discussed. Particular attention is paid to collagen, which is a protein that forms the basis of connective tissue; collagen ensures the strength and elasticity of the skin, which confirms the importance of its role not only in aesthetics but also in the process of wound healing. Different types of collagen and their roles in the mechanisms of chronic wound healing in diabetic foot syndrome are described. The results of clinical studies evaluating the effectiveness of medical products and preparations, consisting of collagen with preserved (native collagen) and fractionated structures, in treating chronic wounds of diabetic foot syndrome are analysed. It has been shown that the use of native collagen preparations is a promising treatment for chronic ulcers and wounds, including diabetic foot syndrome, which makes it possible to increase the effectiveness of treatment and reduce the economic costs of managing these patients.

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Section: Collagenbased Medical Devices and Productsmentioning

confidence: 99%

Section: Collagenbased Medical Devices and Productsmentioning

confidence: 99%

Biological Mechanisms of Chronic Wound and Diabetic Foot Healing: The Role of Collagen

Stupin

Gabitov

Sinel’nikova

et al. 2018

Serbian Journal of Experimental and Clinical Research

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“…Presently, one of the new approaches to the periodontal tissue regeneration is the application of a bioplastic collagen material Collost as a barrier matrix [20]. The gel form of Collost biomaterial is widely used in general surgical practice in the management of chronic wound skin defects of various etiology [21][22][23]. Application of the collagen Collost gel for gum recession treatment, especially as a scaffold in tissue-engineered constructs is considered as a promising technique.…”

Section: Experimental Investigationsmentioning

confidence: 99%

Regenerative Cell Technologies for Gingival Recession Treatment

Рубникович¹,

Denisova²,

Vladimirskaya³

et al. 2018

Sovrem Tehnol Med

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The aim of the study was to assess experimentally the possibility of using mesenchymal stem cells (MSC) and bioplastic material Collost for gingival recession treatment based on the data of morphological alterations in the tissues of pathologically transformed periodontium. Materials and Methods. Random-bred white female rats (60 specimens) were used as a model in the experiment. The operative intervention was performed in the area of incisors of the upper and lower rat jaws. Before the investigations, 1-2 ml of the adipose tissue were harvested from one specimen under sterile conditions in order to obtain allogeneic mesenchymal stem cells. All animals were divided into 5 groups (10 rats in each group) depending on the selected method of treatment: group 1-experimental gingival recession without treatment; group 2-treatment with physiological solution; group 3-experimental gingival recession treatment with 7% Collost gel; group 4-experimental gingival recession treatment with MSC; group 5-experimental gingival recession treatment with MSC and 7% Collost gel. The control group, intact rats, consisted of 10 laboratory animals with a healthy gingiva. The creation of a model of the experimental gingival recession was carried out by mechanical V-shaped excision of periodontal tissues. Results. The isolated form of 7% Collost gel (a bioplastic collagen material) serves in the process of biodegradation as a matrix for the formation of the native connective tissue, provides adhesion of the stem cells and their transformation into pro-and fibroblasts. 7% Collost gel facilitates the reduction of gingival recession and gingival pocket depth, stimulates the process of epithelization. Injections of cell transplant suspension in physiological solution activate the processes of fibroblast differon cell proliferation and cell transformation. The cell transplant suspension in the sterile bioplastic 7% Collost gel enhances the gel and stem cell effects, contributes to the elimination of the atrophic and dystrophic changes in the gums, increase of mechanical strength, reduction of gingival recession and gingival pocket depth.

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“…[29][30][31][32][33] Collagen I type (Collost ® ) does not significantly affect inflammation but is effective as a wound healing stimulator. [34][35][36][37][38][39]…”

Section: Introductionmentioning

confidence: 99%

<p>The Effect of Inflammation on the Healing Process of Acute Skin Wounds Under the Treatment of Wounds with Injections in Rats</p>

Stupin¹,

Мантурова²,

Silina³

et al. 2020

JEP

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Purpose To study the effects of inflammation on the healing process of rats’ acute skin wounds during treatment with different injections. Methods The study was carried out on Wistar rats, on which square wounds were simulated in the back region. Four groups of wounds were studied. On the day of the simulation (day 0), solutions of the drugs were injected into the wounds: an isotonic sodium chloride solution (Control group), mesenchymal stem cells (SC group), collagen (Collagen group), and a deproteinized hemoderivative of calf blood (DHB group). Within 2 weeks, the wound healing process was assessed by observing and calculating changes in the wound areas, temperatures, and epithelialization levels. On days 3, 7, and 14, wound tissue samples were taken for histological examination, morphological analysis of the healing process, and quantitative assessment of granulation layers’ leukocyte infiltration. Results A correlation between the process of inflammation and epithelization during the healing of skin wounds was established. The anti-inflammatory effect of SC injection on the wound edge tissues was determined, as well as the pro-inflammatory effect of DHB, and the absence of effects on the inflammation course under the collagen treatment. Compared to the control group, the transition from the exudative phase of inflammation to the proliferative phase was faster, as well was wound epithelialization in the SC and Collagen groups. A negative correlation between the level of tissue temperature in the center of wounds and their area were recorded, which intensified over time. Conclusion The severity and duration of the inflammation process during wound healing were ambiguous with the use of different injection treatments. This should compel clinicians to use different markers of drug therapy effectiveness during wound healing. Excessive leukocyte infiltration with a low temperature of wounds and a large scab were markers of delayed wound healing.

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Native collagen application in clinical practice for chronic wounds treatment

Cited by 8 publications

References 8 publications

Biological Mechanisms of Chronic Wound and Diabetic Foot Healing: The Role of Collagen

Biological Mechanisms of Chronic Wound and Diabetic Foot Healing: The Role of Collagen

Regenerative Cell Technologies for Gingival Recession Treatment

<p>The Effect of Inflammation on the Healing Process of Acute Skin Wounds Under the Treatment of Wounds with Injections in Rats</p>

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