Natriuretic action of angiotensin(1–7)

DelliPizzi, AnnMarie; Hilchey, Sean D.; Bell-Quilley, Caroline P.

doi:10.1111/j.1476-5381.1994.tb14014.x

Cited by 144 publications

(116 citation statements)

References 6 publications

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“…Pawloski-Dahm and Fink (19) also observed an antidiuretic effect in normal rats chronically infused with Ang- (1-7). In contrast, a natriuretic and diuretic effect of Ang-(1-7) was observed in other studies (16,17). Using isolated perfused rat kidneys, Dellipizzi et al (16) observed a natriuretic effect associated with an increase of urinary volume following infusion of Ang-(1-7).…”

Section: Angiotensin-(1-7) and Hydroelectrolyte Balancementioning

confidence: 41%

“…Additional studies in our laboratory have demonstrated that Ang-(1-7) has a potent antidiuretic effect in water-loaded rats (14) and that its plasma concentration is increased by hemorrhage or by maneuvers known to increase plasma osmolality such as water deprivation and salt load (15). A natriuretic effect of Ang-(1-7) in isolated rat kidneys (16) or in denervated rat kidneys in vivo (17) has also been described. Ongoing studies strongly suggest that these biological effects are mediated by specific receptors (10,11).…”

Section: Introductionmentioning

confidence: 99%

“…Ang II also increases thirst, salt appetite and intestinal sodium absorption, all of which increase the extracellular fluid volume. There is growing evidence, however, that besides Ang II the heptapeptide Ang-(1-7) also plays a physiological role in the control of hydroelectrolyte balance, mainly through its activity on the kidney (14,16,17,22).…”

Section: Renin-angiotensin System and The Kidneymentioning

confidence: 99%

“…However, due to several factors discussed below there is no consensus regarding the major action of Ang-(1-7) in the kidney. Several studies suggest a major role of Ang-(1-7) as a natriuretic peptide (16)(17)(18) while other studies, including ours, point to a major role of this angiotensin in water transport (19)(20)(21)(22). It should be pointed out, however, that, even when apparently contradictory, these studies clearly show that the renal ac-tions of Ang-(1-7) are very complex, apparently involving both the proximal and distal nephron as is also the case for Ang II.…”

Section: Introductionmentioning

confidence: 99%

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Renal actions of angiotensin-(1-7)

Silva¹,

Baracho²,

Passaglio³

et al. 1997

Braz J Med Biol Res

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The heptapeptide angiotensin-(1-7) is considered to be a biologically active endproduct of the renin-angiotensin system. This angiotensin, which is devoid of the most known actions of angiotensin II such as induction of drinking behavior and vasoconstriction, has several selective effects in the brain and periphery. In the present article we briefly review recent evidence for a physiological role of angiotensin-(1-7) in the control of hydroelectrolyte balance.

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Section: Angiotensin-(1-7) and Hydroelectrolyte Balancementioning

confidence: 41%

Section: Introductionmentioning

confidence: 99%

Section: Renin-angiotensin System and The Kidneymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Renal actions of angiotensin-(1-7)

Silva¹,

Baracho²,

Passaglio³

et al. 1997

Braz J Med Biol Res

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show abstract

“…However, the renal effects of this heptapeptide are incompletely understood. In isolated, perfused rat kidneys and anesthetized animals [172,173], ANG-(1-7) has been shown to increase sodium and water excretion and the glomerular filtration rate (GFR) without affecting renovascular resistance. Hence, it is also possible that ANG-(1-7) induces diuresis and natriuresis by inhibiting renal tubular Na+/K+-ATPase [174,175].…”

Section: Actions Of Ang-(1-7) In the Kidneymentioning

confidence: 99%

ANG II, ANG-(1-7), ALDO and AVP biphasic effects on Na+/H+ transport: the role of cellular calcium

Mello-Aires¹,

Dellova²,

Castelo‐Branco³

et al. 2017

Nephrol Renal Dis

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This article reviews the main body of knowledge regarding NHE1 and NHE3 exchangers and their interaction with Angiotensin II, Angiotensin-(1-7), Aldosterone and Arginine Vasopressin, particularly their renal actions. This work addresses the biphasic effects of different hormonal doses on NHE1 or NHE3 in proximal tubule in Wistar, SHR (hypertensives) and their control WKY (normotensives) rats or MDCK cells (which share similarities with the collecting duct). The hormones were applied alone, with their inhibitors or plus agents that change the [Ca 2+ ]i. The data are compatible with hormonal stimulation of these exchangers by increases of [Ca 2+ ]i in lower range, and inhibition at high [Ca 2+ ]i. In MDCK cells and Wistar rats, low doses of ANG II, ALDO or AVP stimulated the exchangers, while high doses inhibited them. ANG-(1-7), in Wistar or WKY rats has inverse, dose-dependent effects. In SHR rats, the biphasic effects of ANG-(1-7) were similar to the effects of ANG II, ALDO or AVP in Wistar rats. The interactions between these effects may represent a mechanism that regulates extracellular volume. In hypertensives animals, a high plasma level of ANG-(1-7) inhibited NHE3 in the proximal tubule, which mitigated hypertension. Figure 6 shows a schematic model to describe these biphasic hormonal effects.

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Nonclassical Renin‐Angiotensin System and Renal Function

Chappell

2012

Comprehensive Physiology

116

137

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The renin-angiotensin-system (RAS) constitutes one of the most important hormonal systems in the physiological regulation of blood pressure through renal and non-renal mechanisms. Indeed, dysregulation of the RAS is considered a major factor in the development of cardiovascular pathologies including kidney injury and blockade of this system by the inhibition of angiotensin converting enzyme (ACE) or blockade of the angiotensin type 1 receptor (AT1R) by selective antagonists constitutes an effective therapeutic regimen. It is now apparent with the identification of multiple components of the RAS within the kidney and other tissues that the system is actually composed of different angiotensin peptides with diverse biological actions mediated by distinct receptor subtypes. The classic RAS can be defined as the ACE-Ang II AT1R axis that promotes vasoconstriction, water intake, sodium retention and other mechanisms to maintain blood pressure, as well as increase oxidative stress, fibrosis, cellular growth and inflammation in pathological conditions. In contrast, the non-classical RAS composed primarily of the AngII/Ang III–AT2R pathway and the ACE2-Ang-(1-7)-AT7R axis generally opposes the actions of a stimulated Ang II-AT1R axis through an increase in nitric oxide and prostaglandins and mediates vasodilation, natriuresis, diuresis, and a reduced oxidative stress. Moreover, increasing evidence suggests that these non-classical RAS components contribute to the therapeutic blockade of the classical system to reduce blood pressure and attenuate various indices of renal injury, as well as contribute to normal renal function.

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Natriuretic action of angiotensin(1–7)

Cited by 144 publications

References 6 publications

Renal actions of angiotensin-(1-7)

Renal actions of angiotensin-(1-7)

ANG II, ANG-(1-7), ALDO and AVP biphasic effects on Na+/H+ transport: the role of cellular calcium

Nonclassical Renin‐Angiotensin System and Renal Function

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