Natural course and prognostic factors of chronic urticaria in Korean children: A single center experience

Park, Hwanhee; Lee, Ji Young; Song, Ari; Jung, Minyoung; Kim, Minji; Sohn, Insuk; Cho, Joongbum; Ahn, Kangmo; Kim, Jihyun

doi:10.12932/ap-151117-0197

Cited by 8 publications

(10 citation statements)

References 26 publications

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“…25 Other recent local studies reported the median onset age of CU to be approximately 4–5 years. 21 26 In the present study, the median age of patients at diagnosis was 5–6 years, similar to recent findings. 21 26 In our study, CU cases were not correlated with age or prognosis, similar to other reports.…”

Section: Discussionsupporting

confidence: 92%

“… 21 26 In the present study, the median age of patients at diagnosis was 5–6 years, similar to recent findings. 21 26 In our study, CU cases were not correlated with age or prognosis, similar to other reports. 21 22 26 However, another study showed a higher remission rate in children below 8 years of age than those in older than 8 years 27 ; the remission rate was also higher in children below the age of 10 years.…”

Section: Discussionsupporting

confidence: 92%

“…Adult women more frequently had CU compared with adult men; however, in children, there was no significant difference in sex. 15 Some studies reported that the remission rate was higher in girls than in boys 27 and that prognosis was worse in girls below the age of 10 years 28 ; however, recent studies reported no significant differences in remission rates according to the sex of the patients, 22 26 29 similar to our study results. Further studies are needed to investigate the association between prognosis and age or sex of pediatric patients with CU.…”

Section: Discussionsupporting

confidence: 87%

“… 16 37 38 Higher total serum IgE levels were associated with longer disease duration, similar to the finding of Kessel et al , 39 wherein total serum IgE levels were commonly high in adults with CU and was related to severity and duration of the disease. Although some pediatric studies reported no association between total IgE and disease outcome, 16 26 Cho et al 29 reported longer duration of the disease in groups with high total serum IgE levels; however, these results were not statistically significant. A future large-scale studies are warranted to determine the association between total serum IgE and the remission rate of CU.…”

Section: Discussionmentioning

confidence: 92%

“…However, the actual frequency of urticaria is either not specifically determined 13 22 34 or varies between reports. 25 26 35 In some cases, the criteria was limited to patients with CU for 6 weeks or more, occurring almost every day, 35 3 times a week, 26 2 times a week, once a week or over. 25 In recent guidelines, CU is defined only as symptoms lasting for more than 6 weeks, without specifying a frequency.…”

Section: Discussionmentioning

confidence: 99%

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Natural History and Influencing Factors of Chronic Urticaria in Children

Kim

Hyun

최봉석

2022

Allergy Asthma Immunol Res

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Purpose Chronic urticaria (CU) can reduce the quality of life of children and their parents, but there are only a few studies on the course of CU in children. This study aimed to investigate the natural course of CU in children and identify the factors that influence its prognosis. Methods We evaluated 77 children diagnosed with CU, who were monitored for at least 48 months. Subjects were classified as either chronic spontaneous urticaria (CSU) or other CU, and the clinical features were compared. Remission was defined as having no symptoms without treatment for more than 1 year. The remission rate was analyzed, and the factors influencing the prognosis were investigated. Results The average age of the study population was 5.96 ± 4.06 years, and 64 (83.1%) patients had CSU. The remission rates at 6 months, 1 year, 2 years, 3 years, and 4 years after symptom onset were 22.1%, 40.3%, 52.0%, 63.7%, and 70.2%, respectively, for children with CU. For children with CSU, these values were 23.4%, 43.7%, 56.2%, 68.7%, and 75.0%, respectively. The total serum immunoglobulin E (IgE) levels were positively correlated with disease duration ( r = 0.262, P = 0.021); no other factors were associated with the duration of the disease. Conclusions A high proportion of children with CU were classified as CSU. No indicators, except for total IgE were found to predict the timing of spontaneous remission. The CU remission rate identified in this study is expected to be used as one of the reference data for the progress of CU in patients.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Natural History and Influencing Factors of Chronic Urticaria in Children

Kim

Hyun

최봉석

2022

Allergy Asthma Immunol Res

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Aeroallergens in Atopic Dermatitis and Chronic Urticaria

Chong

Chwa

Ong

2022

Curr Allergy Asthma Rep

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Atopy and Response to Omalizumab Treatment in Chronic Spontaneous Urticaria

Costa,

Esteves Caldeira,

Paulino

et al. 2023

Int Arch Allergy Immunol

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Introduction: The possible influence of sensitization to aeroallergens on omalizumab response in chronic spontaneous urticaria (CSU) has been insufficiently investigated. This study’s aim was to investigate atopy’s influence on omalizumab response in CSU patients. Method: Retrospective study of CSU patients followed at a Portuguese Urticaria Center of Reference and Excellence (UCARE), treated with omalizumab for at least 6 months, between 2015 and 2022. At T0, all patients underwent quantification of specific immunoglobulin E (IgE) for total extract of most prevalent aeroallergens (ImmunoCAP Thermo Fisher Scientific®) and were divided in 2 groups, according to their response to omalizumab during the first 16 weeks of treatment: responders (R) (UAS7 <7) versus partial (PR) (UAS7 = 7–15) and nonresponders (UAS7 >15). R were further classified as fast (FR) (4–6 weeks) and slow responders (SR) (12–16 weeks). Total serum IgE, circulating eosinophil, and basophil counts were compared between groups at T0. p < 0.05 was considered statistically significant (SPSS® v25.0). Results: Ninety-six patients (80% female) were studied, mean age 49 ± 14 years. Median CSU duration pre-omalizumab was 3 (0.6–20) years and mean omalizumab treatment duration was 3.7 ± 2.3 years. 38 (40%) had concomitant chronic inducible urticaria and 72 (75%) angioedema. Based on positive results of the specific IgE assay, 35 patients (36%) were considered atopic. Most patients (n = 30; 86%) were sensitized to house dust mites (HDM) (Dermatophagoides farinae = 28, Dermatophagoides pteronyssinus = 27, Blomia tropicalis = 19, Lepidoglyphus destructor = 17), followed by pollens (n = 12; 34%) (mixture of grasses = 10, Olea europaea = 7, Parietaria officinalis = 6), epithelia (n = 9; 26%) (dog = 8, cat = 7), and fungi (Alternaria alternata = 4; 11%). Eight patients (23%) were monosensitized to HDM and 4 (11%) to pollens. No significant association was found between aeroallergen sensitization and CSU duration, concomitant chronic inducible urticaria, or angioedema. Atopic patients featured significantly higher levels of baseline total serum IgE than nonatopic (469 vs. 94 U/mL, respectively; p = 0.0009). Mean baseline counts of eosinophils and basophils were not significantly different between atopic and non-atopic, respectively: eosinophils (128 vs. 121/mm3) and basophils (26 vs. 28/mm3). Regarding response to omalizumab, most patients (58; 60%) were responders: FR – 46 (79%); SR – 12 (21%). There was no significant association between aeroallergen sensitization and omalizumab response or speed of response. Conclusions: As far as we know, this is the first study exploring the influence of atopy sensitization pattern on omalizumab response in CSU. According to our results, presence of atopy/sensitization pattern does not influence omalizumab response in CSU patients.

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Natural course and prognostic factors of chronic urticaria in Korean children: A single center experience

Abstract: Background: Chronic urticaria (CU) has an adverse effect on academic achievement and psychosocial development in children.

Cited by 8 publications

References 26 publications

Natural History and Influencing Factors of Chronic Urticaria in Children

Natural History and Influencing Factors of Chronic Urticaria in Children

Aeroallergens in Atopic Dermatitis and Chronic Urticaria

Atopy and Response to Omalizumab Treatment in Chronic Spontaneous Urticaria

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