Natural Fused Heterocyclic Flavonoids: Potent Candidates as Anti- Inflammatory and Anti-Allergic Agents in the Treatment of Asthma

Abstract

: In the last two decades, the flavanoids containing fused heterocyclic nucleus in their chemical structure have emerged to display a variety of pharmacological effects including anti-allergic and anti-inflammatory the most recent to the list. These polyphenolic compounds exert their pharmacological effect by various mechanisms including inhibition of human neutrophil elastase, cytokines (Interleukins- IL-3 and IL-4) and mast cells. Quercetin, Pycnogenol, Rutin and Kampferol are the few bio-flavonols out of hundreds of other compounds still under clinical trials that have been studied most. These flavonoids have been also reported to the other pharmacological effects like anti-cancer, anti-oxidants, anti-hypertensive, anti-viral, anti-ulcerogenic, anti-platelet, anti-hypotensive and anti-hepatotoxic. With all these versatile properties heterocyclic containing flavonoids may be a powerful candidate for the discovery of their utilization in other ailments like asthma.

Exploration of the Pharmacological Mechanism of Bufei Nashen Pill in Treating Chronic Obstructive Pulmonary Disease Using Network Pharmacology Integrated Molecular Docking

“…Quercetin, kaempferol, luteolin and wogonin are all flavonoids, which have different therapeutic activities, and can act as cardioprotective, antiviral, antidiabetic, anti-inflammatory, antibacterial, and anticancer agents. 34 , 35 Research has showed that quercetin can reduce the production of IL-6, IL-8, IL-1β, and TNF-α, and suppress the activation of NF-κB to achieve an anti-inflammatory effect. 36 Moreover, quercetin possesses anticarcinogenic, antioxidant, free-radical scavenging, antifibrotic, and antiproliferative properties, inhibiting apoptosis and enhancing early innate immunity that can be expressed in different cell types and animal models.…”

Exploring plant polyphenols as anti-allergic functional products to manage the growing incidence of food allergy

“…Flavonoids are the polyphenols associated with the most outstanding research progress in recent years. They mainly affect the secretion process of immune cells, mitosis, and the interaction between cells and significantly influence the inhibition of allergic reactions ( 12 ). Flavonoids inhibit the release of the proteolytic enzyme β-hexosaminidase and histamine from mast cells ( 13 , 14 ).…”

Quantitative Study on Anti-Pest Activity of Natural Products Based on Visualization Framework of Knowledge Graph

“…Structurally, they are composed of two benzene rings, connected by an oxygen-containing heterocycle [86] . Flavonoids have antiallergic, anticancer, antioxidant, antibacterial and antiviral properties, and are widely used as insecticides [87][88][89] to control a variety of insect pests, such as P. xylostella, aphids, locusts and tobacco mosaic virus [90][91][92][93] .…”