Natural Gums and Modified Natural Gums as Sustained-Release Carriers

Bhardwaj, T. R.; Kanwar, Meenakshi; Lal, Roshan; Gupta, Anubha

doi:10.1081/ddc-100100266

Cited by 319 publications

(139 citation statements)

References 85 publications

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“…Guar gum, in the form of three-layer matrix tablets, is a potential carrier in the design of oral controlled drug delivery systems for highly water-soluble drugs such as trimetazidine dihydrochloride [10].…”

Section: Fig 1: Structure Of Guar Gummentioning

confidence: 99%

Herbal excipients in Novel Drug Delivery Systems

Chavhan¹,

Shinde²,

Sapkal³

et al. 2017

IRJDPL

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Due to advances in drug delivery technology, currently, excipients are included in novel dosage forms to fulfil specific functions and in some cases, they directly or indirectly influence the extent and/or rate of drug release and drug absorption. Recent trends towards use of plant based and natural products demand the replacement of synthetic additives with natural ones. Today, the whole world is increasingly interested in natural drugs and excipients. These natural materials have many advantages over synthetic ones as they are chemically inert, nontoxic, less expensive, biodegradable, improve the shelf life of product and widely available. This article gives an overview of natural excipients which are used in conventional dosage forms as well as novel drug delivery systems.

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Section: Fig 1: Structure Of Guar Gummentioning

confidence: 99%

Herbal excipients in Novel Drug Delivery Systems

Chavhan¹,

Shinde²,

Sapkal³

et al. 2017

IRJDPL

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“…Chemically, mucilages resemble gums and pectins but differ in their physical properties. Gums swell in water to form sticky, colloidal dispersions and pectins gelatinize in water, while mucilages form slippery, aqueous colloidal dispersions (Bhardwaj et al, 2000;Jani, Shah, 2008). Gums are considered to be pathological products formed upon injury of the plant or owing to unfavorable conditions such as drought, by a breakdown of cell walls (extracellular).…”

Section: Introductionmentioning

confidence: 99%

In vivo mucoadhesive strength appraisal of gum Manilkara zapota

Singh¹,

2015

Braz. J. Pharm. Sci.

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The mucilage (MMZ) extracted from the seeds of Manilkara zapota (Linn.) P. Royen syn. using maceration techniques was evaluated for mucoadhesive strength by various in vitro and in vivo methods. The result showed that mucoadhesive strength of seeds mucilage have comparable property toward natural and synthetic polymers such as Guar Gum and hydroxyl propyl methyl cellulose (HPMC E5LV) under the experimental conditions used in this study. Briefly, it could be concluded that the seed mucilage of Manilkara zapota can be used as a pharmaceutical excipient in oral mucoadhesive drug delivery systems. Further, it may be appropriate to study the changes in these properties after chemical modifications.Uniterms: Manilkara zapota/use/pharmaceutics. Manilkara zapota/evaluation/mucoadhesive strength. Drugs/mucoadhesives/oral delivery systems. Natural polymers. Pharmaceutical excipients.Mucilagem (MMZ) extraída das sementes de Manilkara zapota (Linn.) P. Royen syn utilizando técnicas de maceração foi avaliada por sua força mucoadesiva por vários métodos in vitro e in vivo. O resultado mostrou que a força mucoadesiva das sementes mucilaginosas tem propriedade comparável aos polímeros naturais e sintéticos, tais como goma Guar e hidroxipropilmetil celulose (HPMC E5LV) nas condições experimentais utilizadas neste estudo. Brevemente, se pode concluir que a mucilagem de semente de Manilkara zapota pode ser usada como um excipiente farmacêutico em sistemas de liberação de fármacos mucoadesivos por via oral. Pode ser apropriado o estudo posterior de mudanças nessas propriedades após modificações químicas.Unitermos: Manilkara zapota/uso/farmacotécnica. Manilkara zapota/avaliação/força mucoadesiva. Fármacos/mucoadesivos/sistemas de liberação por via oral. Polímeros naturais. Excipientes farmacêuticos.

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“…11,12 The presence of a number of amino groups permits CGG to chemically react with XG, thus ensuing in amendment of physiochemical characteristics and release performance of such combinations. 13 Diclofenac sodium is used in the long-term symptomatic treatment of an kylosing spondylitis, osteoarthritis and rheumatoid arthritis. Its biologic half-life has been reported as 1-2 h. gastrointestinal side effects are commonly seen.…”

Section: Introductionmentioning

confidence: 99%

Cationic guar gum polyelectrolyte complex micro particles

Sandeep¹,

Deb²,

Moin³

et al. 2014

JYP

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Aim:The aim of this study was to organize polyelectrolyte complex microparticles (PECMP) of cationic guar gum and xanthan gum. Materials and Methods: The complex formed was loaded with diclofenac sodium (DS) as a model drug. The prepared microparticles were characterized by Fourier transform infrared spectroscopy (FT-IR), differential scanning colorimetry (DSC), scanning electron microscopy (SEM), and evaluated for in vivo in vitro properties. Result: DSC and FT-IR studies were done to measure the formation of PEC and confi rmed the absence of chemical interactions between drug and polymers. By SEM, the surface morphology was studied. Particle size ranged between 294 and 300 μm. The percentage of encapsulation effi ciency of the microparticles was found to be 96.47%. In vitro release studies indicated that the drug release extended beyond 12 h. Kinetic analysis of dissolution data indicated that the drug release was by super case II mechanisms. Compared with DS solution, microparticles show low and prolonged drug release when subjected to in vivo pharmacokinetic evaluation in rabbits. Based on in vitro and in vivo studies, it was concluded that these micro particles provided oral controlled release of DS. Conclusion: The research fi ndings obtained from the studies were found to be satisfactory. Hence, PECMP can be effectively used for preparation of sustained-release formulation.

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Natural Gums and Modified Natural Gums as Sustained-Release Carriers

Cited by 319 publications

References 85 publications

Herbal excipients in Novel Drug Delivery Systems

Herbal excipients in Novel Drug Delivery Systems

In vivo mucoadhesive strength appraisal of gum Manilkara zapota

Cationic guar gum polyelectrolyte complex micro particles

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