Natural history and prognosis of choroidal neovascularization

Laey, J. J. De

doi:10.1007/bf00140466

Cited by 5 publications

(4 citation statements)

References 26 publications

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“…[32][33][34][35] Disease progression has been discussed in terms of individual differences in location and lateral extent of a neovascular lesion, and also in associated changes of the choriocapillaris, Bruch's membrane and retinal pigment epithelium. 36 Some of our cases had juxtafoveal or extrafoveal location of the CNV.…”

Section: Discussionmentioning

confidence: 99%

Relationship between foveal birefringence and visual acuity in neovascular age-related macular degeneration

Weber

Elsner

Miura

et al. 2006

Eye

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Purpose To investigate the relationship between visual acuity and foveal birefringence in patients with neovascular age-related macular degeneration. Methods In total, 40 patients with choroidal neovascularization underwent macular imaging with scanning laser polarimetry. Bowtie patterns, typically seen in birefringence images of the macula, were evaluated and classified into three categories: (1) regular bowtie present; (2) bowtie present, but disrupted; and (3) no bowtie present. The relation of the bowtie appearance to the best-corrected logMAR visual acuities was tested (ANOVA). Results Mean visual acuity was best for the group that had regular bowties (mean logMAR ¼ 0.34) and differed statistically significantly from the disrupted bowtie group and no bowtie group (P ¼ 0.01 and 0.0007). Ages for the three groups did not differ (P ¼ 0.31). Conclusions Appearance of a regular bowtie indicates a substantially intact Henle fibre layer with the potential for good visual function, despite the presence of underlying pathology. Conversely, disruption or absence of a bowtie may indicate severe damage to the photoreceptors, consistent with the finding of poorer visual acuity.

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Section: Discussionmentioning

confidence: 99%

Relationship between foveal birefringence and visual acuity in neovascular age-related macular degeneration

Weber

Elsner

Miura

et al. 2006

Eye

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“…Choroidal NV (CNV) is another major cause of severe loss of vision. It occurs in several disorders in which there are abnormalities of the retinal pigmented epithelium (RPE)/Bruch's membrane complex, the most prevalent of which is age‐related macular degeneration (AMD)(Patz et al, 1977; DeLaey, 1983; Ferris et al, 1984; Green and Wilson, 1986). While the pathogenesis of CNV is not as well understood as that of retinal NV and there is no compelling evidence that hypoxia is the driving force for CNV as it is for retinal NV, there is substantial evidence implicating VEGF in CNV.…”

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confidence: 99%

Implication of the hypoxia response element of the vegf promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development

Vinores

Xiao

Aslam

et al. 2005

Journal Cellular Physiology

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Retinal neovascularization (NV) and macular edema, resulting from blood-retinal barrier (BRB) breakdown, are major causes of visual loss in ischemic retinopathies. Choroidal NV (CNV) occurs in diseases of the retinal pigmented epithelium/Bruch's membrane complex and is another extremely prevalent cause of visual loss. We used mice in which the hypoxia response element (HRE) is deleted from the vascular endothelial growth factor (vegf) promoter (Vegf(delta/delta) mice) to explore the role of induction of VEGF through the HRE in these disease processes. Compared to wild type (Vegf+/+) mice with oxygen-induced ischemic retinopathy (OIR) in which vegf mRNA levels were increased and prominent retinal NV and BRB breakdown occurred, Vegf(delta/delta) littermates with OIR failed to increase vegf mRNA levels in the retina and had significantly less retinal NV and BRB breakdown, but showed prominent dilation of some superficial retinal vessels. Vegf(+/delta) littermates with ischemic retinopathy developed comparable retinal NV to Vegf+/+ mice, exhibited intermediate levels of BRB breakdown, and did not show vasodilation. In a mouse model of CNV, due to laser-induced rupture of Bruch's membrane, the area of CNV at Bruch's membrane rupture sites was more than tenfold greater in Vegf+/+ mice than in Vegf(delta/delta) littermates. In contrast to these dramatic differences in pathologic ocular NV, Vegf(delta/delta) mice showed subtle differences in retinal vascular development compared to Vegf+/+ mice; it was slightly delayed, but otherwise normal. These data suggest that induction of VEGF through the HRE in its promoter is critical for retinal and CNV, but not for retinal vascular development.

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“…Serous and/or hemor rhagic detachment of the retinal pigment epithelium and the retina may be considered as active signs of the choroidal neovascular ization. As a result, a cicatricial lesion devel ops and the overlying retina is destroyed [2], Choroidal neovascularization is always found in cases of senile disciform macular degeneration (SDMD), but it may also be associated with other degenerative diseases or with inflammatory, traumatic or neoplas tic lesions [3,4], In general it is believed that a disciform response occurs as a result of choroidal cir culatory insufficiency [3,7], However, the precise way in which the choroidal circula tion is affected in diseased eyes is not well known. In this study, using the technique of indocyanine green (ICG) angiography, we investigated the choroidal circulation in eyes with choroidal neovascularization and at tempted to point out choroidal circulatory disturbances, which might help to under stand the pathogenesis of those diseases.…”

Section: Introductionmentioning

confidence: 99%

Indocyanine Green Angiography of Choroidal Neovascular Membranes

Hayashi

Laey

1985

Ophthalmologica

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The choroidal circulation was studied in 27 eyes with choroidal neovascular diseases by means of fluorescein and indocyanine green (ICG) angiography. In 10 of the cases the disciform response was seen to be associated with either watershed zones of the choroidal circulation or with areas of choroidal circulatory disturbance. This is consistent with the theory that hypoxic regions of the choroid are the underlying cause of macular disciform response.

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Natural history and prognosis of choroidal neovascularization

Cited by 5 publications

References 26 publications

Relationship between foveal birefringence and visual acuity in neovascular age-related macular degeneration

Relationship between foveal birefringence and visual acuity in neovascular age-related macular degeneration

Implication of the hypoxia response element of the vegf promoter in mouse models of retinal and choroidal neovascularization, but not retinal vascular development

Indocyanine Green Angiography of Choroidal Neovascular Membranes

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