2010
DOI: 10.1016/j.bcmd.2010.03.010
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Natural history of Southeast Asian Ovalocytosis during the first 3years of life

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Cited by 24 publications
(8 citation statements)
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“…Secondly, the collection of umbilical cord blood will provide valuable information otherwise rarely available on possible NH predisposing factors, such as the presence of a UGT1A1 polymorphisms (Gly71Arg and TATA promotor) associated with or without Gilbert’s and/or Crigler-Najjar syndrome [16], or Southeast Asian Ovalocytosis [17, 18]. …”
Section: Discussionmentioning
confidence: 99%
“…Secondly, the collection of umbilical cord blood will provide valuable information otherwise rarely available on possible NH predisposing factors, such as the presence of a UGT1A1 polymorphisms (Gly71Arg and TATA promotor) associated with or without Gilbert’s and/or Crigler-Najjar syndrome [16], or Southeast Asian Ovalocytosis [17, 18]. …”
Section: Discussionmentioning
confidence: 99%
“…The incidence of HE is about 2% in different regions of Africa while thalassemia and South East Asian ovalocytosis (SAO) (incidence of 1–1.5%) are prevalent in South East Asia and the Melanesia. SAO (caused by a deletion of nine amino acids in Band 3) can be a hemolytic condition during early childhood but hematologically normal when reaching adulthood. The co‐presence of heterozygous α‐thalassemia and SAO does not seem to produce more severe hemolysis and clinical symptoms.…”
Section: Coexistence Of Membranopathy and Other Red Cell Disordersmentioning
confidence: 99%
“…In South East Asian ovalocytosis (SEAO), the elliptocytes show a transverse (as opposed to longitudinal) zone of central pallor, or two zones of pallor separated by a transverse bar of cytoplasm, or even a zone of central pallor divided into two or three spokes like the open spaces on a sleigh bell. SEAO is considered hematologically benign, although there is a suggestion that it may be responsible for transient anemia in the newborn period . Schistocytes generally reflect intravascular hemolysis. When seen with thrombocytopenia, schistocytes suggest microangiopathic hemolytic anemia (MAHA), a group of conditions consisting primarily of thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), and disseminated intravascular coagulopathy (DIC).…”
Section: Introductionmentioning
confidence: 99%