2017
DOI: 10.2147/ijn.s148438
|View full text |Cite
|
Sign up to set email alerts
|

Natural material-decorated mesoporous silica nanoparticle container for multifunctional membrane-controlled targeted drug delivery

et al.

Abstract: To avoid the side effects caused by nonspecific targeting, premature release, weak selectivity, and poor therapeutic efficacy of current nanoparticle-based systems used for drug delivery, we fabricated natural material-decorated nanoparticles as a multifunctional, membrane-controlled targeted drug delivery system. The nanocomposite material coated with a membrane was biocompatible and integrated both specific tumor targeting and responsiveness to stimulation, which improved transmission efficacy and controlled… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
26
0
3

Year Published

2018
2018
2024
2024

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 34 publications
(29 citation statements)
references
References 46 publications
0
26
0
3
Order By: Relevance
“…We can, therefore, determine that the %EE of our process is approximately 85%. This high yield is obtained thanks to the difference of solubility of MBT between the two phases and to an in situ encapsulation process, higher than the 45% to 60% that is expected for encapsulation of mesoporous silica particles with drugs or enzymes, for instance. In presence of hydroxide ions, the release is then quickly achieved with approximately 50% of the total MBT content released in the first 5 min, and a slower release for up to 2 hr.…”
Section: Resultsmentioning
confidence: 85%
“…We can, therefore, determine that the %EE of our process is approximately 85%. This high yield is obtained thanks to the difference of solubility of MBT between the two phases and to an in situ encapsulation process, higher than the 45% to 60% that is expected for encapsulation of mesoporous silica particles with drugs or enzymes, for instance. In presence of hydroxide ions, the release is then quickly achieved with approximately 50% of the total MBT content released in the first 5 min, and a slower release for up to 2 hr.…”
Section: Resultsmentioning
confidence: 85%
“…Regarding the drug delivery application, polymers are the most preferred innovative materials as the tendency to improve the fate and performance of any therapeutic molecule is high by changing their delivery pattern in addition to offering structural diversities and different functionalities. [ 40 ] Moreover, these polymers act as controlled delivery vehicles for several guest molecules by prolonging the drug effect by maintaining the levels in the therapeutic window. Considering these significant facts, enormous efforts have been put forward to fabricating the versatile surfaces of MSNs by coating with several polymers.…”
Section: Advanced Fabrication Of Msnsmentioning
confidence: 99%
“…MSN modification was adapted from literature [98,99] and was described previously by the authors [40]. Approximately, 200 mg of MSNs and 15 mg of chitosan (C) in 40 mL of acetic acid (10 % v/v), and stirred at ambient temperature over 24 h. The CMSNs were then centrifuged, washed with absolute ethanol and thereafter with deionized water, and dried at 60 • C for 24 h. For modification with polyethylene glycol (P) and chitosan (C), 22.5 mg of C and 179 mg or 449 mg of polyethylene glycol 2000 were added separately to dilute acetic acid (30 mL, 2%; pH 4.6), followed by the addition of 7.725 mg of TPP (15 mL in 18 MΩ water).…”
Section: Msn Modification With Chitosan and Polyethyleneglycolmentioning
confidence: 99%