Natural Products and Nanotechnology Against Coronavirus Disease 2019

Abstract

Coronavirus disease 2019 (COVID-19) is a new and severe infectious disease and new global disaster and is spreading rapidly worldwide. Natural products have a long history and have been widely used to treat various acute, chronic, and even life-threatening diseases worldwide. However, the natural products have reduced bioavailability and availability as they have poor kinetic properties, such as large molecular weight, inability to cross lipid membranes, and weak absorption ability. With the rapid development of nanotechnology, using novel nanotechnology in conjunction with natural products can effectively eliminate the molecular restriction of the entry of nanoproducts into the body and can be used to diagnose and treat various diseases, including COVID-19, bringing new strategies and directions for medicine. This article reviews the role and implementation of natural products against COVID-19 based on nanotechnology.

Novel targeted pH-responsive drug delivery systems based on PEGMA-modified bimetallic Prussian blue analogs for breast cancer chemotherapy

“…60 Nanotechnology has developed rapidly in recent years and provides an excellent means to overcome the bottleneck of conventional therapies that cause non-specic effects on body tissues, improve the effectiveness of drug and radiation therapy, and greatly reduce adverse effects. [61][62][63] These materials can be used as drug carriers, imaging contrast agents, photothermal materials, photoacoustic compounds and radiation dose enhancers. 64,65 Recently, with the increased understanding of acidic TME, it has been recognized as a new target for tumor diagnosis and treatment, which has important implications for the design of pH-responsive nanomedicines.…”

“…60 Nanotechnology has developed rapidly in recent years and provides an excellent means to overcome the bottleneck of conventional therapies that cause non-specific effects on body tissues, improve the effectiveness of drug and radiation therapy, and greatly reduce adverse effects. 61–63 These materials can be used as drug carriers, imaging contrast agents, photothermal materials, photoacoustic compounds and radiation dose enhancers. 64,65…”

Smart Nanoparticles for Breast Cancer Treatment Based on the Tumor Microenvironment

“…Nanotechnology has developed rapidly in recent years, providing a good means to overcome the bottleneck problem of nonspecific and non-selective damage to body tissues caused by traditional therapies (e.g., chemotherapy, radiotherapy and immunotherapy), and exhibiting unique advantages in improving the effects of drugs and radiation therapy while reducing adverse reactions (44,(56)(57)(58). On the one hand, multifunctional nanocarriers can selectively transport therapeutic drugs by utilizing the difference between the tumor tissue and normal tissue to enhance drug permeability and retention.…”

Nanomaterials in Animal Husbandry: Research and Prospects

“…Nanomaterial will be a viable treatment to save more lives since nanomaterial makes it easier to create simple, quick, and low-cost diagnostic assays for SARS-CoV-2 and associated biomarkers ( Zeng et al, 2021 ). Studies have shown that nanomaterial can effectively deliver viral antigens to antigen-presenting cells or serve as adjuvants in the host, so as to produce vaccine rapidly ( Zeng et al, 2022 ). And treatments based on nanomaterials may also decrease SARS-CoV-2 multiplication and reduce inflammation ( Phuna et al, 2022 ).…”