Natural products as potential anticonvulsants: Caffeoylquinic acids

Kim, Hyo Geun; Oh, Myung Sook

doi:10.1007/s12272-012-0300-y

Cited by 6 publications

(5 citation statements)

References 27 publications

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“…Caffeoylquinic acid derivatives are esters of caffeic and quinic acids, and exhibit antioxidative effects that contribute to neuroprotection by reducing reactive oxygen species (ROS) . DCQAs in Brazilian green propolis have also been shown to exert neuroprotective effects via antioxidative activity when used in cases of retinal damage …”

Section: Introductionmentioning

confidence: 99%

“…6 Caffeoylquinic acid derivatives are esters of caffeic and quinic acids, and exhibit antioxidative effects that contribute to neuroprotection by reducing reactive oxygen species (ROS). 7 DCQAs in Brazilian green propolis have also been shown to exert neuroprotective effects via antioxidative activity when used in cases of retinal damage. 8 The antioxidative properties of chicoric acid and DCQAs can contribute to retinal degeneration, because oxidative stress plays an important role in the pathogenesis of glaucomatous optic neuropathy due to apoptotic degeneration of retinal ganglion cells (RGCs).…”

Section: ■ Introductionmentioning

confidence: 99%

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Hydroxycinnamic Acids in Crepidiastrum denticulatum Protect Oxidative Stress-Induced Retinal Damage

Ahn

Lee

Kim

et al. 2014

J. Agric. Food Chem.

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We investigated the effects of an ethanol extract of C. denticulatum (EECD) in a mouse model of glaucoma established by optic nerve crush (ONC), and found that EECD significantly protected against retinal ganglion cell (RGC) death caused by ONC. Furthermore, EECD effectively protected against N-methyl-d-aspartate-induced damage to the rat retinas. In vitro, EECD attenuated transformed retinal ganglion cell (RGC-5) death and significantly blunted the up-regulation of apoptotic proteins and mRNA level induced by 1-buthionine-(S,R)-sulfoximine combined with glutamate, reduced reactive oxygen species production by radical species, and inhibited lipid peroxidation. The major EECD components were found to be chicoric acid and 3,5-dicaffeoylquinic acid (3,5-DCQA) that have shown beneficial effects on retinal degeneration both in vitro and in vivo studies. Thus, EECD could be used as a natural neuroprotective agent for glaucoma, and chicoric acid and 3,5-DCQA as mark compounds for the development of functional food.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Hydroxycinnamic Acids in Crepidiastrum denticulatum Protect Oxidative Stress-Induced Retinal Damage

Ahn

Lee

Kim

et al. 2014

J. Agric. Food Chem.

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“…Organic acids and flavonoids are the main effective ingredients in FL 41 . Neochlorogenic acid (P13), chlorogenic acid (P14), cryptochlorogenic acid (P15), 3,4-dicaffeoylquinic acid (P20), and 3,5-dicaffeoylquinic acid (P21) are organic acids.…”

Section: Discussionmentioning

confidence: 99%

Discovery of Anti-inflammatory Ingredients in Chinese Herbal Formula Kouyanqing Granule based on Relevance Analysis between Chemical Characters and Biological Effects

Liu

Zheng

et al. 2015

Sci Rep

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Kouyanqing Granule (KYQG) is a traditional Chinese herbal formula composed of Flos lonicerae (FL), Radix scrophulariae (RS), Radix ophiopogonis (RO), Radix asparagi (RA), and Radix et rhizoma glycyrrhizae (RG). In contrast with the typical method of separating and then biologicalily testing the components individually, this study was designed to establish an approach in order to define the core bioactive ingredients of the anti-inflammatory effects of KYQG based on the relevance analysis between chemical characters and biological effects. Eleven KYQG samples with different ingredients were prepared by changing the ratios of the 5 herbs. Thirty-eight ingredients in KYQG were identified using Ultra-fast liquid chromatography-Diode array detector-Quadrupole-Time-of-flight-Tandem mass spectrometry (UFLC-DAD-Q-TOF-MS/MS) technology. Human oral keratinocytes (HOK) were cultured for 24 hours with 5% of Cigarette smoke extract (CSE) to induce inflammation stress. Interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumour necrosis factor-α (TNF-α) were evaluated after treatment with the eleven KYQG samples. Grey relational analysis(GRA), Pearson’s correlations (PCC), and partial least-squares (PLS) were utilized to evaluate the contribution of each ingredient. The results indicated that KYQG significantly reduced interleukin-1β, interleukin-6, interleukin-8, and tumour necrosis factor-α levels, in which lysine, γ-aminobutyric acid, chelidonic acid, tyrosine, harpagide, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isoquercitrin, luteolin-7-o-glucoside, 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, angoroside C, harpagoside, cinnamic acid, and ruscogenin play a vital role.

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“…Natural products contain a wide variety of antioxidants, including phenolic acids and flavonoids (4). Most of the pharmacological activities of A. glehni are related to phenolic compounds (5). Since there have been no reports of quantitative phytochemical evaluations of A. glehni , the aim of this study was to examine the phenol and flavonoid content, and corresponding antioxidant activities, of A. glehni extracted with different solvents.…”

Section: Dear Editor-in-chiefmentioning

confidence: 99%