Naturally derived scaffolds for dental pulp regeneration: a review

Osman, Zul Faizuddin; Ahmad, Azlina; Noordin, Khairul Bariah Ahmad Amin

doi:10.26657/gulhane.00060

Cited by 4 publications

(2 citation statements)

References 41 publications

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“…Various stem cells can be found in teeth and their associate tissues, such as stem cells from human exfoliated deciduous teeth (SHED), dental pulp stem cells (DPSC), stem cells from the apical papilla (SCAP), periodontal ligament stem cells (PDLC), dental follicle precursor cells (DFPC), dental papilla cells (DPC), dental mesenchymal stem cells (DMSCs), and dental epithelial stem cells (DESCs). For pulp regeneration purposes, SHED, DPSC, and SCAP have strong potential [35,41,[53][54][55].…”

Section: Induced Pluripotent Cellsmentioning

confidence: 99%

Tissue Engineering with Stem Cell from Human Exfoliated Deciduous Teeth (SHED) and Collagen Matrix, Regulated by Growth Factor in Regenerating the Dental Pulp

et al. 2022

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Maintaining dental pulp vitality and preventing tooth loss are two challenges in endodontic treatment. A tooth lacking a viable pulp loses its defense mechanism and regenerative ability, making it more vulnerable to severe damage and eventually necessitating extraction. The tissue engineering approach has drawn attention as an alternative therapy as it can regenerate dentin-pulp complex structures and functions. Stem cells or progenitor cells, extracellular matrix, and signaling molecules are triad components of this approach. Stem cells from human exfoliated deciduous teeth (SHED) are a promising, noninvasive source of stem cells for tissue regeneration. Not only can SHEDs regenerate dentin-pulp tissues (comprised of fibroblasts, odontoblasts, endothelial cells, and nerve cells), but SHEDs also possess immunomodulatory and immunosuppressive properties. The collagen matrix is a material of choice to provide structural and microenvironmental support for SHED-to-dentin pulp tissue differentiation. Growth factors regulate cell proliferation, migration, and differentiation into specific phenotypes via signal-transduction pathways. This review provides current concepts and applications of the tissue engineering approach, especially SHEDs, in endodontic treatment.

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Section: Induced Pluripotent Cellsmentioning

confidence: 99%

Tissue Engineering with Stem Cell from Human Exfoliated Deciduous Teeth (SHED) and Collagen Matrix, Regulated by Growth Factor in Regenerating the Dental Pulp

et al. 2022

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“…hyaluronic acid, cellulose, polysaccharides or amniotic membrane) with resveratrol, growth factors and pulp stem cells, improves their growth and proliferation rate due to downregulation of proinflammatory cytokines and anti-oxidant properties [23,37]. Even though synthetic scaffolds (self-assembling peptide or PLGA) create more space for optimization, natural scaffolds retain the native ability to cooperate with bioactive signalling molecules, aiding local regeneration of periodontal ligament (dental connective tissue) [38]. In vitro overexpressed vascular endothelial growth factor (VEGF) enhances DPSCs proliferation and cell migration, at the same time expanding angiogenesis (e.g.…”

Section: Tissue Regeneration and Cell Therapymentioning

confidence: 99%

Human Dental Pulp Stem Cells: recent findings and current research

Janowicz

Mozdziak

Bryja

et al. 2019

Medical Journal of Cell Biology

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Prevalence of neurodegenerative diseases, most of which are life threatening and incurable, is an increasing clinical problem. To date, studies have demonstrated a superior proliferation rate of dental pulp stem cells (DPSCs) compared to other mesenchymal stem cells in vitro. DPSCs has recently been recognized as a novel treatment strategy for neurodegenerative disease, due to their advanced potential for neurogenic differentiation. The oral cavity has been described as a promising source of dental pulp stem cells. DPSCs are widely used in regenerative dentistry holding alternative capacity for osteogenic differentiation and therefore new promises for tissue and whole tooth regeneration. Dental stem cell banking offers a plentiful source of stem cells representing great potential for cell reprogramming and thus cell therapy. Recently, the association of pulp stem cells with three – dimensional scaffold templates allows for building up naturally derived implants. This review introduces to unique properties of DPSCs and biological factors influencing mineralization, proliferation and differentiation of pulp stem cells. Latest research studies are compared in terms of effectiveness and limitations of techniques for the isolation of pulp stem cells, including the enzymatic digestion and the explant culture methods. Moreover, a short overview of most recent findings and clinical application of DPSCs is proffered including progress of current research and limitations still to be addressed in the nearest future. Finally, the article presents new advances in the area of regenerative dentistry and regenerative medicine, including three dimensional printing and three dimensional analysis, emerged to deepen studies under procedures to replace the non patient specific artificial implants.Running title: DPSCs - review

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