Naturally-occurring antisperm antibodies in men interference with fertility and implications for treatment

Francavilla, Felice; Romano, Rossella; Santucci, R.; G, La Verghetta; D'Abrizio, Piera; Francavilla, Sandro

doi:10.2741/a475

Cited by 8 publications

(10 citation statements)

References 174 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…, 2006), or history of genital tract infections in the past 3 months were preliminarily excluded from the study. Ejaculates with antisperm antibodies detected by the mixed antiglobulin reaction test (Francavilla et al. , 1999), or with a leukocyte number beyond the WHO (1999) threshold of leukocytospermia (≥1 × 10 6 /mL) were also excluded.…”

Section: Methodsmentioning

confidence: 99%

Seminal macrophages in ejaculates from men with couple infertility

et al. 2009

Self Cite

View full text Add to dashboard Cite

Seminal macrophages are occasionally reported though their relevance in the evaluation of human ejaculate is unknown. Activated macrophages, engaging in sperm phagocytosis (spermiophages), might represent a marker of innate immunosystem activation. We investigated whether the presence of spermiophages in non-leukocytospermic ejaculates from men complaining for couple infertility is associated with altered sperm features. Four hundred and thirty-four ejaculates were retrospectively analysed after excluding samples with antisperm antibodies, or a leukocyte number >or=1 x 10(6)/mL. Semen quality was compared in samples with or without spermiophages detected with transmission electron microscope. Presence of spermiophages, observed in 27% of ejaculates, was associated with a decreased number of sperm total count (p < 0.0001), of sperm forward motility (p = 0.048), and to an increased fraction of degenerating sperm (p = 0.0002) compared to ejaculates without spermiophages. A low number of total ejaculated sperm and an increased number of degenerating sperm independently predicted the presence of spermiophages (odds ratio 1.72; 95% confidence intervals 1.10 to 2.28 and odds ratio 1.85; 95% confidence intervals 1.19 to 2.88 respectively). Data demonstrate that activated macrophages, a marker of the innate immunosystem activation, are frequently observed in non-leukocytospermic ejaculates of men suffering for couple infertility and this may be associated with altered sperm parameters. Ultrastructural analysis gives qualitative informations, hence sensitive quantitative tests should better define the association between semen activated macrophages and oligoasthenozoospermia and the possible relevance of this finding in the clinical evaluation of the male partner of couple infertility.

show abstract

Section: Methodsmentioning

confidence: 99%

Seminal macrophages in ejaculates from men with couple infertility

et al. 2009

Self Cite

View full text Add to dashboard Cite

show abstract

“…Par contre, il semble que la pr6sence d'ASA m~me ~ un taux bas dans le mucus cervical soit une cause s6v~re d'infertilit6 f6minine [30]. I1 existe des arguments cliniques et biologiques importants en faveur de leur effet sur la fertilit6 [18,36,70,83,103,104]. Ils constituent souvent le seul facteur 6tiologique retrouv6 [48].…”

Section: Interference Des Asa Avec La Fertiliteunclassified

“…Dans 80% des cas o~ le test aux immunobilles est supErieur ~ 10%, il existe des ASA [24,26]. I1 faut toutefois prEciser qu'~ part quelques exceptions, la plupart des Etudes 6pidEmiologiques ne trouvent pas de differences significatives dans les principaux param~tres spermatiques entre les groupes d'hommes infertiles avec ou sans anticorps [36].…”

Section: Signes D'appel Biologiques A) Les Anomalies Du Spermogrammeunclassified

“…En pr6sence de plus de 70%, ou de 90 % d'anticorps (selon les auteurs), IgG ou IgA, il est conseill6 de proposer d'embl6e une ICSI, surtout si les ASA sont situ6s sur la t~te du gamete [1,26,36,72,88,99].…”

Section: C) Echecs De Fdcondation Ou Pauci-f~condation En Fiv Classiqunclassified

“…Les causes immunologiques de l'infertilit6 du couple sont souvent EvoquEes mais sont ?a l'heure actuelle toujours dEbattues [2,36,48,68,69].…”

Section: Introductionunclassified

See 2 more Smart Citations

Indications de la recherche des anticorps anti-spermatozoïdes

Barthélémy

2003

Androl.

View full text Add to dashboard Cite

Interactive effect of semen and cervical mucus quality on postcoital test outcome: analysis from an andrological point of view

Francavilla¹,

Romano²,

Verghetta³

et al. 2002

Int J of Andrology

View full text Add to dashboard Cite

This study analysed the relationship between semen quality and the postcoital test (PCT) outcome in 616 couples, especially focusing on the interactive effect of semen and cervical mucus quality. When PCTs performed in the presence of unfavourable mucus were excluded, a significant correlation was found between semen parameters and PCT outcome. In oligo/asthenozoospermia, 46.7% of PCT outcomes were negative, while the remaining were positive. Notably, in the presence of an optimal mucus score, 39% of PCT outcomes were good (> or = 7 forward motile spermatozoa/high power field). In normozoospermia, 16% of PCT were negative. A suboptimal cervical mucus quality significantly affected the PCT outcome in the presence of oligo/asthenozoospermia, but not in normozoospermia. In couples with repeated PCT, a better mucus score was associated with a significant improvement of the PCT outcome. When the outcome of two PCTs performed in the same couples with an unmodified mucus score was compared, a good consistency of the results was observed. In conclusion, the PCT can provide information in additional to that obtained from conventional semen analysis, as the interactive effect of semen/cervical mucus cannot be accurately inferred from the separate evaluation of the two members of a couple.

show abstract

Naturally-occurring antisperm antibodies in men interference with fertility and implications for treatment

Cited by 8 publications

References 174 publications

Seminal macrophages in ejaculates from men with couple infertility

Seminal macrophages in ejaculates from men with couple infertility

Indications de la recherche des anticorps anti-spermatozoïdes

Interactive effect of semen and cervical mucus quality on postcoital test outcome: analysis from an andrological point of view

Contact Info

Product

Resources

About