Naturally occurring cell adhesion inhibitors

Takamatsu, Satoshi

doi:10.1007/s11418-018-1220-z

Cited by 14 publications

(12 citation statements)

References 82 publications

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“…VCAM-1 plays an essential role in mediating the infiltration of leukocytes into tissues ( Takamatsu, 2018 ). We therefore examined whether the VCAM-1 antibody could alter macrophage adhesion and migration to HUVECs in vitro .…”

Section: Resultsmentioning

confidence: 99%

“…VCAM-1, a cell adhesion molecule (CAM), is a transmembrane type I protein that is mainly expressed on ECs during inflammation ( Cook-Mills et al, 2011 ). Previous studies have suggested that VCAM-1 plays an essential role in regulating the inflammatory response and the development of related diseases by mediating the leukocyte adhesion to and infiltration into tissues ( Takamatsu, 2018 ). VCAM-1 gene expression is regulated by multiple transcription factors and cytokines, including NF-kB, Ap-1, SP-1, IL-1β, and TNF-α ( Cook-Mills et al, 2011 ; Lee et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

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Blocking VCAM-1 Prevents Angiotensin II-Induced Hypertension and Vascular Remodeling in Mice

Yin

Bai

et al. 2022

Front. Pharmacol.

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Adhesion of monocytes to the vascular endothelium frequently leads to an inflammatory response, which contributes to hypertension and vascular remodeling. Vascular cellular adhesion molecule-1 (VCAM-1) plays an important role in leukocyte adhesion and migration during inflammatory diseases. However, its role in angiotensin (Ang) II -induced hypertension and vascular dysfunction remains largely unknown. Wild-type (WT) mice were administered a VCAM-1 neutralizing antibody (0.1 or 0.2 mg/mouse/day) or IgG control and then infused with Ang II (490 ng kg−1 min−1) or saline continuously for 14 days. Systolic blood pressure (SBP) was measured with a tail-cuff system, pathological changes in the aorta were assessed by histological staining, and vascular relaxation was analyzed an aortic ring assay. Our results indicated that compared with saline infusion, Ang II infusion significantly upregulated VCAM-1 expression in the mouse aorta and serum. Moreover, Ang II infusion markedly increased arterial hypertension, wall thickness, fibrosis, infiltration of Mac-2+ macrophages, reactive oxygen species (ROS) production and vascular relaxation dysfunction. Conversely, blockade of VCAM-1 with a neutralizing antibody substantially alleviated these effects. In vitro experiments further confirmed that the VCAM-1 neutralizing antibody inhibited Ang II-induced macrophage adhesion and migration and DNA damage and oxidative stress in endothelial cells (ECs). In conclusion, these results indicate that blockade of VCAM-1 exerts a protective effect against Ang II-induced arterial hypertension and dysfunction by regulating monocytes adhesion and infiltration into the endothelium and represents a novel therapeutic approach for hypertension.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Blocking VCAM-1 Prevents Angiotensin II-Induced Hypertension and Vascular Remodeling in Mice

Yin

Bai

et al. 2022

Front. Pharmacol.

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“…An array of natural products isolated from plant material (terpenoids, lignans etc. ), or from microbial (efomycine M) or marine origin, have initially demonstrated in vitro inhibition of CAMs, however, no further clinical development can be identified ( 50 ). Employing the rational design-driven approach, a series of glycomimetic inhibitors were derived from the structure of the selectin ligand sialyl Lewis X (sLe X ).…”

Section: Drug Candidates-inhibitors Of Cams: Mabs and Small Moleculesmentioning

confidence: 99%

Endothelial Cell Adhesion Molecules- (un)Attainable Targets for Nanomedicines

Milošević

Rütter

David

2022

Front. Med. Technol.

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Endothelial cell adhesion molecules have long been proposed as promising targets in many pathologies. Despite promising preclinical data, several efforts to develop small molecule inhibitors or monoclonal antibodies (mAbs) against cell adhesion molecules (CAMs) ended in clinical-stage failure. In parallel, many well-validated approaches for targeting CAMs with nanomedicine (NM) were reported over the years. A wide range of potential applications has been demonstrated in various preclinical studies, from drug delivery to the tumor vasculature, imaging of the inflamed endothelium, or blocking immune cells infiltration. However, no NM drug candidate emerged further into clinical development. In this review, we will summarize the most advanced examples of CAM-targeted NMs and juxtapose them with known traditional drugs against CAMs, in an attempt to identify important translational hurdles. Most importantly, we will summarize the proposed strategies to enhance endothelial CAM targeting by NMs, in an attempt to offer a catalog of tools for further development.

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“…), are macrolides produced by several fungal strains, for example Microsphaeropsis sp. [ 241 ]. These compounds and metabolites from the peribysin group are also detailed in Table 11 .…”

Section: Natural Compounds Of Plant Animal and Fungal Originmentioning

confidence: 99%

Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based Isolation

et al. 2021

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Plants and fungi can be used for medical applications because of their accumulation of special bioactive metabolites. These substances might be beneficial to human health, exerting also anti-inflammatory and anticancer (antiproliferative) effects. We propose that they are mediated by influencing cellular adhesion and migration via various signaling pathways and by directly inactivating key cell adhesion surface receptor sites. The evidence for this proposition is reviewed (by summarizing the natural metabolites and their effects influencing cellular adhesion and migration), along with the classical measuring techniques used to gain such evidence. We systematize existing knowledge concerning the mechanisms of how natural metabolites affect adhesion and movement, and their role in gene expression as well. We conclude by highlighting the possibilities to screen natural compounds faster and more easily by applying new label-free methods, which also enable a far greater degree of quantification than the conventional methods used hitherto. We have systematically classified recent studies regarding the effects of natural compounds on cellular adhesion and movement, characterizing the active substances according to their organismal origin (plants, animals or fungi). Finally, we also summarize the results of recent studies and experiments on SARS-CoV-2 treatments by natural extracts affecting mainly the adhesion and entry of the virus.

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Naturally occurring cell adhesion inhibitors

Cited by 14 publications

References 82 publications

Blocking VCAM-1 Prevents Angiotensin II-Induced Hypertension and Vascular Remodeling in Mice

Blocking VCAM-1 Prevents Angiotensin II-Induced Hypertension and Vascular Remodeling in Mice

Endothelial Cell Adhesion Molecules- (un)Attainable Targets for Nanomedicines

Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based Isolation

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