Nature and Significance of Somatic Antigens of Oral Bacteria

Mergenhagen, S. E.

doi:10.1177/00220345670460013901

Cited by 39 publications

(9 citation statements)

References 17 publications

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“…Dose (ig/ml) It is not surprising that endotoxins from several bacterial sources can stimulate bone resorption, in view of the similarities of their chemical and biological properties (7). Other genera of bacteria which produce endotoxin have been isolated from the human mouth besides B. melaninogenicus (15). The endotoxin derived from B. melaninogenicus is unique in that it does not contain 2-keto-3-deoxyoctonate, a component found in other endotoxins (16); however, it produces reactions typical of endotoxin in rabbits (17), such as elevation in body temperature and local Shwartzman reactions in the skin.…”

mentioning

confidence: 99%

Endotoxin: Stimulation of Bone Resorption in Tissue Culture

Hausmann

Raisz

Miller

1970

Science

181

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Bacterial endotoxins can stimulate the release of previously incorporated calcium-45 and tritiated proline from fetal rat bone in tissue culture. Endotoxin from Bacteroides melaninogenicus, an organism regularly found in the gingival crevice of man, produces a response similar to parathyroid hormone and is effective at doses as low as 0.1 microgram per milliliter. This response is inhibited by serum and dependent upon the presence of albumin. Endotoxins may play a role in the bone loss characteristic of human periodontal disease.

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confidence: 99%

Endotoxin: Stimulation of Bone Resorption in Tissue Culture

Hausmann

Raisz

Miller

1970

Science

181

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“…Dose (tg/ml) [ It is not surprising that endotoxins from several bacterial sources can stimulate bone resorption, in view of the similarities of their chemical and biological properties (7). Other genera of bacteria which produce endotoxin have been isolated from the human mouth besides B. melaninogenicus (15). The endotoxin derived from B. melaninogenicus is unique in that it does not contain 2-keto-3-deoxyoctonate, a component found in other endotoxins (16); however, it produces reactions typical of endotoxin in rabbits (17), such as elevation in body temperature and local Shwartzman reactions in the skin.…”

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confidence: 99%

Teratogenic Evaluation of 2,4,5-T

Courtney

Gaylor

Hogan

et al. 1970

Science

167

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The herbicide 2,4,5-trichlorophenoxyacetic acid is teratogenic and fetocidal in two strains of mice when administered either subcutaneously or orally and in one strain of rats when administered orally. The incidences of both cystic kidney and cleft palate were increased in the C57BL/6 mice as well as the incidence of cleft palate in the AKR mice. The incidence of cystic kidney was also increased in the rats. In addition, an increase in the ratio of liver weight to body weight in the mouse fetus and the occurrence of hemorrhagic gastrointestinal tract in the rat fetus suggest that this compound also has fetotoxic properties.

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“…Bacteria may continue to stimulate antibody formation locally in regional lymph nodes and in adjacent tissues (Mergenhagen, 1967).…”

Section: Cervicoradicular Infections Have Been Induced In Rodents Bymentioning

confidence: 99%