Naucleamides A—E, New Monoterpene Indole Alkaloids from Nauclea latifolia.

Shigemori, Hideyuki; Kagata, Toshinori; Ishiyama, Haruaki; Morah, Frank Ni; Ohsaki, Ayumi; Kobayashi, Jun’ichi

doi:10.1002/chin.200323198

Cited by 7 publications

(10 citation statements)

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“…Phytochemical investigations on Nauclea species have revealed the presence of terpenes and/or secoridoids (Adebowale et al, 1983;Lamidi et al, 1995a), quinovic acid and derivatives (Lamidi et al, 1995b), saponins (Lamidi et al, 1997) and alkaloids (Hotellier et al, 1979;Lin et al, 1985, 1989: Zeches et al, 1985Deeni and Hussain, 1991;Erdelmeier et al, 1991;Anam, 1997;Zhang et al, 2001;Ngnokam et al, 2003;Shigemori et al, 2003;Takayama et al, 2003). All antimalarial activity previously reported in Nauclea species has been attributed to the presence of saponins (Lamidi et al, 1996) or alkaloids (Traore-Keita et al, 2000).…”

Section: Nauclea Pobeguiniimentioning

confidence: 92%

Antimalarial activities and toxicities of three plants used as traditional remedies for malaria in the Democratic Republic of Congo:Croton mubango , Nauclea pobeguiniiandPyrenacantha staudtii

Mesia

Tona

Penge

et al. 2005

Annals of Tropical Medicine & Parasitology

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The antimalarial activities of crude extracts and 17 fractions from the partition of 80%-methanolic extracts of three plants (the stem bark of Croton mubango, the stem bark of Nauclea pobeguinii and the leaves of Pyrenacantha staudtii) used as antimalarial remedies in the Democratic Republic of Congo were studied both in vitro (against Plasmodium falciparum) and in mice infected with Pl. berghei berghei. The toxic effects of dried aqueous extracts of the plants were also investigated, in uninfected mice. The most active crude extracts in vitro, with median inhibitory concentrations (IC(50)) of <1 microg/ml, were found to be the methanolic and dichloromethane extracts of C. mubango, and the dichloromethane extracts of N. pobeguinii and Py. staudtii. The aqueous extract with the most antimalarial activity in vitro was that of C. mubango (IC(50) = 3.2 microg/ml), followed by that of N. probeguinii (IC(50) = 5.3 microg/ml) and then that of Py. staudii (IC(50) = 15.2 microg/ml). Results from the in-vivo tests of antimalarial activity showed that, at a daily oral dose of 200 mg/kg, all the dichloromethane extracts, the petroleum-ether, chloroformic, ethyl-acetate and residual water-soluble fractions from C. mubango, and the chloroformic, ethyl-acetate and n-butanolic fractions from Py. staudtii produced >80% chemosuppression of the parasitaemias by day 4. The aqueous extracts of C. mubango and N. probeguinii produced a slightly lower but still significant inhibition of parasitaemia (60%-80%) whereas that of Py. staudtii only suppressed the day-4 parasitaemias by 37%. The dried aqueous extract of the stem bark of C. mubango showed some signs of toxicity in mice, with median lethal doses (LD(50)) of 350 mg/kg in the female mice and 900 mg/kg in the male. The extract significantly increased the serum concentrations of glutamate-oxaloacetate transaminase (GOT) and glutamate-pyruvate transaminase (GPT) in mice of both sexes, but had no effect on the blood levels of creatinine or urea. No significant toxic effect was observed for the dried aqueous extracts of N. pobeguinii and Py. staudtii (LD(50) >5 g/kg). Neither of these extracts affected the serum concentrations of GPT or the blood concentrations of creatinine and urea, although the N. pobeguinii extract did increase the serum concentration of GOT.

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Section: Nauclea Pobeguiniimentioning

confidence: 92%

Antimalarial activities and toxicities of three plants used as traditional remedies for malaria in the Democratic Republic of Congo:Croton mubango , Nauclea pobeguiniiandPyrenacantha staudtii

Mesia

Tona

Penge

et al. 2005

Annals of Tropical Medicine & Parasitology

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“…The studied plant did not fell short of expectation in this regard as the quantitative phytochemical screening revealed the presence of most of these important bioactive constituents. Alkaloids, flavonoid, terpenoids, saponins and glycosides have all been implicated to posses antiplasmodial activity [22,23] among other beneficial effects. Alkaloids are well recognized bioactive compounds with potent therapeutic activity, they are also, the parent compounds for synthetic products like chloroquine [7].…”

Section: Discussionmentioning

confidence: 99%

The Modulatory Activity of <i>Justicia carnea</i> in Plasmodium Infected Mice

Chidi¹,

Mattew²,

Benjamin³

et al. 2018

TJSR

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The study investigated the antiplasmodial potency of Justicia carnea in plasmodium infected mice. The aqueous leaf extract of Justicia carnea was subjected to phytochemical screening using GC-FID. The suppressive, prophylactic and curative activity of the studied plant was accessed after oral administration of standard drugs (5mgkg-1 choroquine and 4mgkg-1 artesunate) and 400-800mgkg-1 of the extract. The effect of the aqueous leaf extract of the studied plant was also explored in the activities of liver enzymes, oxidative stress markers and hematological indices of plasmodium infected mice using spectrophotomertic methods and a hematology auto analyzer (BC 5300 Mindray England) respectively. The aqueous leaf extract of Justicia carnea showed considerable dose dependent antiplasmodial activity in the suppressive, prophylactic and curative test conducted. The suppressive activity of (92%) of the aqueous leaf extract of the studied plant at 800mgkg-1 was comparable to the standard drugs used while the mean survival time of plasmodium infected mice at 800mgkg-1 was beyond the mean survival time of the infected untreated group. The aqueous leaf extract of the studied plant also exhibited significant improvements in the activities of liver enzymes, oxidative stress markers and some hematological parameters at 800mgkg-1 of the extract when compared with the infected and untreated group. The results of the study exhibited the antiplasmodial activity of the studied plant, nonetheless, the crude extracts of the studied plant can be further purified for synergistic use with other potent antimalarial drugs to combat and achieve total clearance of plasmodium resistant infections.

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“…The above data revealed that the structure of 1 was similar to that of naucleamide A (2) [6]. The only significant difference was the presence of one methylene carbon signal at δ 36.6 instead of one methine carbon at δ 48.8 and one methylene carbon signal at δ 62.9 in naucleamide A (2) [6]. Detailed analysis of spectroscopic data revealed that the hydroxymethyl at C-16 in naucleamide A ( 2 2.…”

mentioning

confidence: 82%

“…Phytochemical studies on this genus have led to the isolation of various skeletal types of monoterpenoid indole alkaloids with antitumor activities, which have attracted pharmacologists' attention [2][3][4][5]. As a part of our ongoing research into structurally and biologically interesting alkaloids from tropical medicinal plants in China, a chemical investigation of O. borbonica was thus undertaken and led to the isolation and characterization of a new monoterpenoid indole alkaloid, ochroborbone (1), together with five known alkaloids, naucleamide A (2) [6], corynantheol (3) [7], sitsirikine (4) [8], 19, 20-dihydroisositsirikine (5) [9], and 10hydroxy-19, 20-dihydroisositsirikine (6) [10]. Among them, ochroborbone (1) is a rare C17-nor monoterpenoid indole alkaloid, and the known compounds (2-6) were isolated from Ochrosia for the first time.…”

mentioning

confidence: 99%

Ochroborbone, A New Cytotoxic Indole Alkaloid from Ochrosia borbonica

Liu

Chen

et al. 2017

Natural Product Communications

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A new monoterpenoid indole alkaloid, ochroborbone (1), along with five known alkaloids (2-6), were isolated from the stems and leaves of Ochrosia borbonica. Among them, ochroborbone (1) is a rare C17-nor monoterpenoid indole alkaloid, and the known compounds (2-6) were isolated from Ochrosia for the first time. These structures were established on the basis of extensive spectroscopic methods. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1 and 2 exhibited inhibitory effects with IC 50 values comparable with those of cisplatin.

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Naucleamides A—E, New Monoterpene Indole Alkaloids from Nauclea latifolia.

Cited by 7 publications

References 1 publication

Antimalarial activities and toxicities of three plants used as traditional remedies for malaria in the Democratic Republic of Congo:Croton mubango , Nauclea pobeguiniiandPyrenacantha staudtii

Antimalarial activities and toxicities of three plants used as traditional remedies for malaria in the Democratic Republic of Congo:Croton mubango , Nauclea pobeguiniiandPyrenacantha staudtii

The Modulatory Activity of <i>Justicia carnea</i> in Plasmodium Infected Mice

Ochroborbone, A New Cytotoxic Indole Alkaloid from Ochrosia borbonica

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