Near-Infrared Fluorescent Nanoprobes for in Vivo Optical Imaging

Quek, Chai Hoon; Leong, Kam W.

doi:10.3390/nano2020092

Cited by 99 publications

(65 citation statements)

References 139 publications

(152 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, the use of http nanoparticles as carrier systems for NIRF-emitting dyes was shown to improve their admission, prolong their circulation time in the body, intensify their fluorescence and improve their photostability [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional calcium phosphate nanoparticles for combining near-infrared fluorescence imaging and photodynamic therapy

et al. 2015

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Multifunctional calcium phosphate nanoparticles for combining near-infrared fluorescence imaging and photodynamic therapy

et al. 2015

View full text Add to dashboard Cite

“…[30][31][32] An additional advantage of RE-NPs is that they can be used for high resolution fluorescence bioimaging by using CW laser sources; much simpler and affordable that the short pulse lasers required for traditional fluorescence probes used in multiphoton fluorescence microscopy. 33 In addition, the RE-NPs display, in some cases, the additional ability of chemical and thermal luminescence sensing. 32,34 This last feature is of special relevance, since it could be used for thermal monitoring and, hence, for real time controlled photo-thermal therapies.…”

mentioning

confidence: 99%

Nd3+ doped LaF3 nanoparticles as self-monitored photo-thermal agents

Rocha

Kumar

Jacinto

et al. 2014

Applied Physics Letters

129

105

View full text Add to dashboard Cite

In this work, we demonstrate how LaF 3 nanoparticles activated with large concentrations (up to 25%) of Nd 3þ ions can simultaneously operate as biologically compatible efficient nanoheaters and fluorescent nanothermometers under single beam (808 nm) infrared laser excitation. Nd 3þ :LaF 3 nanoparticles emerge as unique multifunctional agents that could constitute the first step towards the future development of advanced platforms capable of simultaneous deep tissue fluorescence bio-imaging and controlled photo-thermal therapies. V C 2014 AIP Publishing LLC.

show abstract

“…17 In particular, the applicability in the second biological window (II-BW) opens up the possibility of not only deep tissue imaging but also of high contrast, autofluorescence free in vivo fluorescence thermal sensing, as it has already been demonstrated in imaging applications. [18][19][20][21][22][23][24][25] As an additional requirement, the multifunctional NPs to be used should operate under infrared radiation single beam excitation at wavelength avoiding any non-selective cellular damage. Recent studies dealing with the heating effects and the light-induced cytotoxicity during in vitro imaging experiments have pointed out 808 nm as an optimal excitation wavelength, since it simultaneously minimizes both the laser-induced thermal loading of the tissue and the intracellular photochemical damage.…”

mentioning

confidence: 99%

LaF3 core/shell nanoparticles for subcutaneous heating and thermal sensing in the second biological-window

Ximendes

Rocha

Kumar

et al. 2016

Applied Physics Letters

View full text Add to dashboard Cite

We report on Ytterbium and Neodymium codoped LaF 3 core/shell nanoparticles capable of simultaneous heating and thermal sensing under single beam infrared laser excitation. Efficient light-to-heat conversion is produced at the Neodymium highly doped shell due to non-radiative deexcitations. Thermal sensing is provided by the temperature dependent Nd 3þ ! Yb 3þ energy transfer processes taking place at the core/shell interface. The potential application of these core/shell multifunctional nanoparticles for controlled photothermal subcutaneous treatments is also demonstrated. Published by AIP Publishing. [http://dx.doi.org/10.1063/1.4954170] Photothermal therapy (PTT) is a therapeutic strategy in which photon energy is converted into heat to cause irreversible damage at the cellular level and that could efficiently treat a great variety of diseases including cancer tumors. [1][2][3] In particular, nanoparticle (NP) based PTTs are attracting great attention nowadays. They are based on the use of nanoheaters (NHs), which are NPs with large light-to-heat conversion efficiencies. [4][5][6] The selective incorporation of NHs into cancer cells or tumors provides the means by which a subsequent optical excitation produces a temperature increment that will only affect the tissues aimed to be treated. The net effects caused on cancer tumors during PTTs strongly depend on both the magnitude of the heating as well as the treatment duration. [7][8][9][10] In this regard, in order to achieve an efficient treatment and keep the collateral damage at minimum it is extremely necessary to have a temperature reading during NP based PTTs. As a consequence, there has been an increasing interest in the design of multifunctional luminescent NPs capable of simultaneous heating and thermal sensing under single power excitation as they would constitute significant building blocks toward the achievement of real controlled PTTs as well as subcutaneous studies. 11 Despite the continuously growing list of systems that could operate as simultaneous NHs and nanothermometers (NThs), including polymeric NPs, quantum dots, nanodiamonds, metallic NPs, and rare earth-doped NPs, only a few of them show real potential of working subcutaneously. 12-14 This is so because most of them operate in the visible spectrum domain, where optical penetration into tissues is minimal. To avoid this limitation, it is necessary to shift their operation spectral range from the visible to the spectral infrared ranges where tissues become partially transparent (due to simultaneous attenuation in both tissue absorption and scattering), lying in the so-called biological windows (BWs). 15,16 Traditionally, three biological windows are defined: the first extending from 650 up to 950 nm, the second covering the infrared region about 1000-1350 nm and the third extending from 1500 up to 1750 nm. 17 In particular, the applicability in the second biological window (II-BW) opens up the possibility of not only deep tissue imaging but also of high contrast, autofluorescence free in ...

show abstract

Near-Infrared Fluorescent Nanoprobes for in Vivo Optical Imaging

Cited by 99 publications

References 139 publications

Multifunctional calcium phosphate nanoparticles for combining near-infrared fluorescence imaging and photodynamic therapy

Multifunctional calcium phosphate nanoparticles for combining near-infrared fluorescence imaging and photodynamic therapy

Nd3+ doped LaF3 nanoparticles as self-monitored photo-thermal agents

LaF3 core/shell nanoparticles for subcutaneous heating and thermal sensing in the second biological-window

Contact Info

Product

Resources

About