Near-Infrared-II Cyanine/Polymethine Dyes, Current State and Perspective

Du, Yijing; Liu, Xiangping; Zhu, Shoujun

doi:10.3389/fchem.2021.718709

Cited by 37 publications

(25 citation statements)

References 43 publications

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“…Compared with organic synthesis and modification of cyanine dyes 29 , 31 , 32 , albumin interaction affords an alternative strategy to improve their imaging properties, especially for in vivo settings 21 , 22 , 24 - 30 . However, much less is known on the interaction mechanism between cyanine dyes and albumin, and we still lack complete guidance to manufacture a super-stable complex probe with precise control of the combination parameters.…”

Section: Introductionmentioning

confidence: 99%

Super-stable cyanine@albumin fluorophore for enhanced NIR-II bioimaging

Bai¹,

Hu²,

Han³

et al. 2022

Theranostics

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Near-infrared-II (NIR-II) dyes could be encapsulated by either exogenous or endogenous albumin to form stable complexes for deep tissue bioimaging. However, we still lack a complete understanding of the interaction mechanism of the dye@albumin complex. Studying this principle is essential to guide efficient dye synthesis and develop NIR-II probes with improved brightness, photostability, etc . Methods: Here, we screen and test the optical and chemical properties of dye@albumin fluorophores, and systematically investigate the binding sites and the relationship between dye structures and binding degree. Super-stable cyanine dye@albumin fluorophores are rationally obtained, and we also evaluate their pharmacokinetics and long-lasting NIR-II imaging abilities. Results: We identify several key parameters of cyanine dyes governing the supramolecular/covalent binding to albumin, including a six-membered ring with chlorine (Cl), the small size of side groups, and relatively high hydrophobicity. The tailored fluorophore (IR-780@albumin) exhibits much-improved photostability, serving as a long-lasting imaging probe for NIR-II bioimaging. Conclusion: Our study reveals that the chloride-containing cyanine dyes with the above-screened chemical structure (e.g. IR-780) could be lodged into albumin more efficiently, producing a much more stable fluorescent probe. Our finding partly solves the photobleaching issue of clinically-available cyanine dyes, enriching the probe library for NIR-II bioimaging and imaging-guided surgery.

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Section: Introductionmentioning

confidence: 99%

Super-stable cyanine@albumin fluorophore for enhanced NIR-II bioimaging

Bai¹,

Hu²,

Han³

et al. 2022

Theranostics

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“…Polymethine cyanine-based dye IR1061 (λem = 1061 nm in methylene chloride) is a typical small-molecule organic fluorophore whose emission wavelength is in the NIR-II window, which is composed of two heterocyclic terminal groups connected by the polymethine linker [ 12 ]. Although it is commercially available, low water solubility and short circulation time limiting its biological applications [ 13 ]. In order to improve its biomedical applications, the hydrophobic dye has been fabricated into a variety of platforms such as polymers [ 14 , 15 ], lipid [ 16 ] and nanoprobe [ 17 , 18 ] for in vivo imaging or therapeutic applications.…”

Section: Introductionmentioning

confidence: 99%

J-aggregates albumin-based NIR-II fluorescent dye nanoparticles for cancer phototheranostics

Liu

et al. 2022

Materials Today Bio

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“…Compared with the most commonly used excitation wavelength 808 nm, 1,064 nm light has both deeper tissue penetration and higher maximum permissible exposure (MPS) intensity (1 vs. 0.33 W/cm 2 )( Zhen et al, 2021 ) ( Zhang et al, 2020b ). Such feature makes NIR-II fluorescence imaging under 1,064 nm excitation have a much better imaging depth and resolution than that under 808-nm excitation ( Du et al, 2021 ). However, it is difficult to design and synthesize organic NIR-II fluorescence probes with NIR-II excitation wavelength.…”

Section: Introductionmentioning

confidence: 99%

Organic Fluorophores for 1064 nm Excited NIR-II Fluorescence Imaging

Wang

et al. 2021

Front. Chem.

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Second near-infrared window (NIR-II) fluorescence imaging has shown great potential in the field of bioimaging. However, the excitation wavelengths of most NIR-II fluorescence dyes are in the first near-infrared (NIR-I) region, which leads to limited imaging depth and resolution. To address such issue, NIR-II fluorescence dyes with 1,064 nm excitation have been developed and applied for in vivo imaging. Compared with NIR-I wavelength excited dyes, 1,064 nm excited dyes exhibit a higher tissue penetration depth and resolution. The improved performance makes these dyes have much broader imaging applications. In this mini review, we summarize recent advances in 1,064 nm excited NIR-II fluorescence fluorophores for bioimaging. Two kinds of organic fluorophores, small molecule dye and semiconducting polymer (SP), are reviewed. The general properties of these fluorophores are first introduced. Small molecule dyes with different chemical structures for variety of bioimaging applications are then discussed, followed by the introduction of SPs for NIR-II phototheranostics. Finally, the conclusion and future perspective of this field is given.

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Near-Infrared-II Cyanine/Polymethine Dyes, Current State and Perspective

Cited by 37 publications

References 43 publications

Super-stable cyanine@albumin fluorophore for enhanced NIR-II bioimaging

Super-stable cyanine@albumin fluorophore for enhanced NIR-II bioimaging

J-aggregates albumin-based NIR-II fluorescent dye nanoparticles for cancer phototheranostics

Organic Fluorophores for 1064 nm Excited NIR-II Fluorescence Imaging

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