Near-infrared multispectral photoacoustic microscopy using a graded-index fiber amplifier

Buma, Takashi; Farland, Jessica L.; Ferrari, Margaret R.

doi:10.1016/j.pacs.2016.08.002

Cited by 14 publications

(7 citation statements)

References 29 publications

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“…Following these initial studies, increasing attention is turned to optical imaging windows in longer near-infrared II (NIR II) wavelength regions, presenting peaks of lipid absorption spectrums in such regions of 1100-1300 nm and 1650-1850 nm. This reveals obviously differentiated peaks with higher lipid absorption coefficients compared with other primary components of endogenous agents in biological tissue, such as oxyhemoglobin, deoxyhemoglobin, and water [34][35][36][37][38][39].…”

Section: Quintessential Components In Vulnerable Plaque Characterizationmentioning

confidence: 99%

Multimodal photoacoustic imaging in analytic vulnerability of atherosclerosis

Zhou,

Chen,

et al. 2023

iRADIOLOGY

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Atherosclerosis is a major cause of mortality and morbidity, and rupture can lead to myocardial infarction and stroke. The vulnerability assessment of atherosclerosis plaques is important for providing medical treatment. Identifying vulnerable plaques requires noninvasive, high‐resolution imaging techniques for capturing and locating high‐risk markers. Photoacoustic imaging (PAI) is a hybrid and novel imaging modality that uses nonionizing excitation and has substantial promise for vulnerability assessment of atherosclerosis. The current review examined current applications of multimodal PAI for identification of atherosclerosis plaques. Furthermore, we discuss the challenges and limitations in the implementation this method and future research directions to overcome these difficulties. First, we discuss two aspects of vulnerable plaque characterization: large necrotic cores and thin degraded cap component identification. Then, we then discuss applications of high‐risk plaque characterization, including intraplaque hemorrhage and heme degradation markers detection. We hope that this review will shed light on the potential application of optical imaging techniques in atherosclerosis identification and facilitate further studies that will ultimately lead to the broader application of multimodal PAI in clinical practice.

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Section: Quintessential Components In Vulnerable Plaque Characterizationmentioning

confidence: 99%

Multimodal photoacoustic imaging in analytic vulnerability of atherosclerosis

Zhou,

Chen,

et al. 2023

iRADIOLOGY

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“…In contrast to the optical gain offered by a rare-earth dopant, the Raman gain is not selective for the pump laser. As a result, the SRS-based source was also demonstrated with a 1060-nm pump laser, which can cover the lipid absorption band at 1210 nm [ 39 ]. Furthermore, by controlling the optical delays of each wavelength, functional imaging can be achieved using a single laser source.…”

Section: Fiber Laser Sources For Pammentioning

confidence: 99%

Fiber laser technologies for photoacoustic microscopy

Jin

Liang

2021

Vis. Comput. Ind. Biomed. Art

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Fiber laser technology has experienced a rapid growth over the past decade owing to increased applications in precision measurement and optical testing, medical care, and industrial applications, including laser welding, cleaning, and manufacturing. A fiber laser can output laser pulses with high energy, a high repetition rate, a controllable wavelength, low noise, and good beam quality, making it applicable in photoacoustic imaging. Herein, recent developments in fiber-laser-based photoacoustic microscopy (PAM) are reviewed. Multispectral PAM can be used to image oxygen saturation or lipid-rich biological tissues by applying a Q-switched fiber laser, a stimulated Raman scattering-based laser source, or a fiber-based supercontinuum source for photoacoustic excitation. PAM can also incorporate a single-mode fiber laser cavity as a high-sensitivity ultrasound sensor by measuring the acoustically induced lasing-frequency shift. Because of their small size and high flexibility, compact head-mounted, wearable, or hand-held imaging modalities and better photoacoustic endoscopes can be enabled using fiber-laser-based PAM.

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“…Ultimately, since the PA technique aims to be translated into clinical application, the research of fully integrated PAM [39] , [40] , [41] and high-speed PAM [42] , [43] , [44] , [45] , [46] , [47] have been actively progressed. Fiber-based light sources such as the supercontinuum (SC) sources [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] and stimulated Raman scattering source (SRS) sources [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] have been suggested for high-speed multispectral or functional PA imaging. The nonlinear effect can be maximized at a relatively low pump threshold power owing to the advantages of the nonlinear effective length and effective area with an optical fiber-based configuration [70] .…”

Section: Introductionmentioning

confidence: 99%