Near‐Infrared Upconversion Luminescence and Bioimaging In Vivo Based on Quantum Dots

Qiu, Xiaochen; Zhu, Xingjun; Su, Xianlong; Xu, Ming; Yuan, Wei; Liu, Qingyun; Meng, Xue; Liu, Yawei; Feng, Wei; Li, Fuyou

doi:10.1002/advs.201801834

Cited by 52 publications

(26 citation statements)

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“…Taking all these factors into consideration, it is still difficult for different wavelength dual emission ratiometric nanothermometers to eliminate errors originating from tissue absorption and scattering in vivo. Recently, there has been renewed interest in UCL emission of quantum dots (QDs), which can be excited by a broad wavelength light under a low power density [38][39][40][41] . Due to the participation of phonons in this UCL process, the UCL emission shows excellent temperature-dependent properties, which make it a suitable candidate for fabricating a nanothermometer.…”

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Ratiometric upconversion nanothermometry with dual emission at the same wavelength decoded via a time-resolved technique

et al. 2020

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The in vivo temperature monitoring of a microenvironment is significant in biology and nanomedicine research. Luminescent nanothermometry provides a noninvasive method of detecting the temperature in vivo with high sensitivity and high response speed. However, absorption and scattering in complex tissues limit the signal penetration depth and cause errors due to variation at different locations in vivo. In order to minimize these errors and monitor temperature in vivo, in the present work, we provided a strategy to fabricate a samewavelength dual emission ratiometric upconversion luminescence nanothermometer based on a hybrid structure composed of upconversion emissive PbS quantum dots and Tm-doped upconversion nanoparticles. The ratiometric signal composed of two upconversion emissions working at the same wavelength, but different luminescent lifetimes, were decoded via a time-resolved technique. This nanothermometer improved the temperature monitoring ability and a thermal resolution and sensitivity of~0.5 K and~5.6% K −1 were obtained in vivo, respectively.

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Ratiometric upconversion nanothermometry with dual emission at the same wavelength decoded via a time-resolved technique

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“…S2 †). 26 Dynamic light scattering (DLS) measurements were used to investigate the hydrodynamic diameter of FeP nanoparticles (Fig. S3 †).…”

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Iron phosphide nanoparticles as a pH-responsive T₁ contrast agent for magnetic resonance tumor imaging

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“…The excitation power density for the absolute QY measurement was 0.30 W cm −2 . The absolute QY was calculated from the following equation

QY = \frac{photons emitted}{photons absorbed} = \frac{(I_{sample} - I_{ref .})}{(S_{ref .} - S_{sample}) \times 1.477 / 2.1 % / 0.9 %}

…”

Section: Methodsmentioning

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Upconversion Lifetime Imaging of Highly‐Crystalline Gd‐Based Fluoride Nanocrystals Featuring Strong Luminescence Resulting from Multiple Luminescent Centers

Zeng

Zhang

et al. 2019

Advanced Optical Materials

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Highly‐crystalline Gd‐based fluoride upconversion (UC) nanocrystals, including orthorhombic‐phase GdF3:Yb/Er nanoplates (NPLs), hexagonal‐phase NaGdF4:Yb/Er NPLs, monoclinic‐phase K3GdF6:Yb/Er nanoribbons (NRs), and orthorhombic‐phase KGdF4:Yb/Er NRs are controllably synthesized through a simple yet robust method, with all of the products exhibiting strong UC luminescence. Notably, the obtained K3GdF6:Yb/Er NRs have an exceptional quantum yield as high as 0.84% at a low excitation laser power (0.30 W cm−2, 975 nm), as well as long single‐particle UC lifetimes (τ) for green (τ = 0.70 ms) and red (τ = 1.10 ms) emissions. The enhanced luminescence is attributed to the “multiple luminescent center effect,” which is verified via the laser‐selective excitation spectra of deliberately introduced Eu3+ dopants. This method can be extended to the preparation of a number of other nanocrystals, and the UC nanocrystals featuring high luminescence efficiencies can be further tailored for biomedical applications.

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Near‐Infrared Upconversion Luminescence and Bioimaging In Vivo Based on Quantum Dots

Cited by 52 publications

References 35 publications

Ratiometric upconversion nanothermometry with dual emission at the same wavelength decoded via a time-resolved technique

Ratiometric upconversion nanothermometry with dual emission at the same wavelength decoded via a time-resolved technique

Iron phosphide nanoparticles as a pH-responsive T₁ contrast agent for magnetic resonance tumor imaging

Upconversion Lifetime Imaging of Highly‐Crystalline Gd‐Based Fluoride Nanocrystals Featuring Strong Luminescence Resulting from Multiple Luminescent Centers

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Near‐Infrared Upconversion Luminescence and Bioimaging In Vivo Based on Quantum Dots

Cited by 52 publications

References 35 publications

Ratiometric upconversion nanothermometry with dual emission at the same wavelength decoded via a time-resolved technique

Ratiometric upconversion nanothermometry with dual emission at the same wavelength decoded via a time-resolved technique

Iron phosphide nanoparticles as a pH-responsive T1 contrast agent for magnetic resonance tumor imaging

Upconversion Lifetime Imaging of Highly‐Crystalline Gd‐Based Fluoride Nanocrystals Featuring Strong Luminescence Resulting from Multiple Luminescent Centers

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Iron phosphide nanoparticles as a pH-responsive T₁ contrast agent for magnetic resonance tumor imaging