Negative impact of Novaluron on the nontarget insect Bombyx mori (Lepidoptera: Bombycidae)

Santorum, Marilucia; Brancalhão, Rose Meire Costa; Guimarães, Ana Tereza Bittencourt; Padovani, Carlos Roberto; Tettamanti, Gianluca; Santos, Daniela Carvalho dos

doi:10.1016/j.envpol.2019.02.095

Cited by 17 publications

(8 citation statements)

References 44 publications

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“…Selectively effective biorational insecticides are considered to have less risk to beneficial organisms compared with broad-spectrum pesticides [ 19 ]. The general mechanism of benzoylphenylureas is to inhibit the biochemical processes, leading to the formation of chitin synthetase, causing an abnormal deposition of the endocuticle [ 2 ]. For this reason, chitin synthesis inhibitors (CSIs), such as novaluron, have become alternatives to conventional insecticides and have been widely used in agriculture because the CSIs do not kill the pests based on directly toxic effects.…”

Section: Discussionmentioning

confidence: 99%

“…Novaluron is anticipated to decrease the dependence on organophosphates such as diazinon, pyrethroids, and carbamate insecticides [ 1 ]. The mode of action of novaluron is not well documented, but the general mechanisms and effects are similar to those of benzoylphenylureas, which inhibit the biochemical processes, resulting in the formation of chitin synthetase, causing an abnormal deposition of the endocuticle [ 2 ]. This insecticide primarily affects the larval stages, causing death by abnormal endocuticular deposition and disturbing molting, and hence, benzoylphenylurea compounds are known as chitin synthesis inhibitors (CSIs).…”

Section: Introductionmentioning

confidence: 99%

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Novaluron Has Detrimental Effects on Sperm Functions

Hwang

Bae

Jung

et al. 2021

IJERPH

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Although novaluron is an insect growth regulator with a low mammalian acute toxicity and a low risk to the environment and nontarget organisms, toxic effects of novaluron have been reported. However, no studies have yet evaluated the effect of novaluron on reproduction. Therefore, we examined the effects of novaluron on sperm functions. The spermatozoa of ICR mice were incubated with various concentrations of novaluron to induce capacitation. Then, sperm motion parameters and capacitation status were evaluated using CASA program and H33258/chlortetracycline staining. In addition, PKA activity and tyrosine phosphorylation were evaluated by Western blotting. After exposure, various sperm motion parameters were significantly decreased in a dose-dependent manner. The acrosome reaction was also significantly decreased in the high concentration groups. Sperm viability was significantly reduced at the highest concentration. In addition, PKA activity and tyrosine phosphorylation were also significantly altered. Thus, novaluron affects sperm viability, sperm motility, and motion kinematics during capacitation. Furthermore, it may promote the reduction in acrosome reactions. The physiological suppression of sperm function may depend on abnormal tyrosine phosphorylation via the alteration of PKA activity. Therefore, we suggest that it is necessary to consider reproductive toxicity when using novaluron as a pesticide.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novaluron Has Detrimental Effects on Sperm Functions

Hwang

Bae

Jung

et al. 2021

IJERPH

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“…Besides PFCs, commercial fluorinated insecticides, such as benzoylphenylureas (BPUs) and their derivatives, are also widely used sources of HOCs in the environment. Triflumuron (TFM), diflubenzuron (DFB) and novaluron are common BPUs, and studies have shown these compounds are toxic for aquatic organisms and they bioaccumulate (up to 160 times) from water (Pereira Maduenho and Martinez, 2008;Santorum et al, 2019;Timoumi et al, 2019). Furthermore, DFB metabolites, such as 4-chloroaniline, are more toxic to fish than the parent compound and are classified as probable carcinogens.…”

Section: Fluorinated Organic Compoundsmentioning

confidence: 99%

Enzymatic assays for the assessment of toxic effects of halogenated organic contaminants in water and food. A review

Artabe

Cunha-Silva

Barranco

2020

Food and Chemical Toxicology

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Halogenated organic compounds are a particular group of contaminants consisting of a large number of substances, and of great concern due to their persistence in the environment, potential for bioaccumulation and toxicity. Some of these compounds have been classified as persistent organic pollutants (POPs) under The Stockholm Convention and many toxicity assessments have been conducted on them previously. In this work we provide an overview of enzymatic assays used in these studies to establish toxic effects and dose-response relationships. Studies in vivo and in vitro have been considered with a particular emphasis on the impact of halogenated compounds on the activity of relevant enzymes to the humans and the environment. Most information available in the literature focuses on chlorinated compounds, but brominated and fluorinated molecules are also the target of increasing numbers of studies. The enzymes identified can be classified as enzymes: i) the activities of which are affected by the presence of halogenated organic compounds, and ii) those involved in their metabolisation/detoxification resulting in increased activities. In both cases the halogen substituent seems to have an important role in the effects observed. Finally, the use of these enzymes in biosensing tools for monitoring of halogenated compounds is described.

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“…Efeitos adversos sobre o bicho-da-seda (Santorum et al, 2019(Santorum et al, , 2020) e outros insetos não alvo (Stacke et al, 2019).…”

Section: Novaluromunclassified

Agrotóxicos: críticas à regulação que permite o envenenamento do país

Hess

Nodari

Lopes-Ferreira

2021

Desenvolv. Meio Ambiente

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O artigo contém uma análise das autorizações para a comercialização e o consumo de agrotóxicos no país na última década, bem como os seus efeitos na saúde humana e no meio ambiente. No período entre 2010 e 2018, a quantidade de agrotóxicos comercializados no Brasil aumentou mais do que o dobro do que cresceu a área cultivada no país. A permissividade da gestão de agrotóxicos no Brasil é ilustrada pelo fato de que, do total de ingredientes ativos químicos com registro no país em julho de 2020, 121 (30%) não tinham uso permitido na União Europeia (EU). A razão da proibição do uso na EU dos produtos autorizados no Brasil, no período referido, está associada aos efeitos adversos a humanos e a outros organismos resultantes da exposição aos ingredientes químicos de agrotóxicos, já descritos na literatura científica. Soja, milho, algodão e cana-de-açúcar constam entre as culturas que tiveram o maior número de novos agrotóxicos com uso autorizado no Brasil entre janeiro de 2019 e junho de 2020. Outra falta de rigor na gestão de agrotóxicos é ilustrada pela deriva, que causa danos agudos e crônicos a terceiros. Adicionalmente, a fragilidade da norma brasileira refere-se ao estabelecimento de um valor de dose, abaixo da qual eles seriam seguros. Contudo, resultados experimentais de estudos mostraram, por exemplo, que os agrotóxicos à base de glifosato, melation e piriproxifem causaram a morte de embriões de peixes em apenas 24 horas de exposição, independentemente da concentração utilizada, desafiando assim a hipótese de que existe dose segura para a exposição a tais produtos. Dessa forma, é urgente não só aumentar o rigor científico dos estudos sobre o tema, mas também promover a participação pública nas tomadas de decisão, garantindo o acesso a todas as informações contidas nos dossiês que acompanham as solicitações de registro e de autorização dos agrotóxicos.

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Negative impact of Novaluron on the nontarget insect Bombyx mori (Lepidoptera: Bombycidae)

Cited by 17 publications

References 44 publications

Novaluron Has Detrimental Effects on Sperm Functions

Novaluron Has Detrimental Effects on Sperm Functions

Enzymatic assays for the assessment of toxic effects of halogenated organic contaminants in water and food. A review

Agrotóxicos: críticas à regulação que permite o envenenamento do país

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