Neglected analytes in the 24-h urine: ammonium and sulfate

Asplin, John R.

doi:10.1097/mnh.0000000000000766

Cited by 11 publications

(2 citation statements)

References 41 publications

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“…In the present study, urinary excretion of sulfate and creatinine were significantly lower in patients with Crohn’s disease than in healthy controls. Since the majority of urinary sulfate is derived from sulfur-containing amino acids, sulfate excretion is a suitable biomarker of dietary intake and metabolism of protein [ 40 , 41 ]. Moreover, urinary creatinine excretion reflects muscle mass, as creatinine is a waste product of muscle metabolism [ 42 , 43 ].…”

Section: Discussionmentioning

confidence: 99%

Intestinal Oxalate Absorption, Enteric Hyperoxaluria, and Risk of Urinary Stone Formation in Patients with Crohn’s Disease

Siener,

Ernsten,

Speller

et al. 2024

Nutrients

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Nephrolithiasis is a common urologic manifestation of Crohn’s disease. The purpose of this study was to investigate the clinical characteristics, intestinal oxalate absorption, and risk factors for urinary stone formation in these patients. In total, 27 patients with Crohn’s disease and 27 healthy subjects were included in the present study. Anthropometric, clinical, and 24 h urinary parameters were determined, and the [13C2]oxalate absorption test was performed. Among all patients, 18 had undergone ileal resection, 9 of whom had a history of urinary stones. Compared to healthy controls, the urinary excretion values of calcium, magnesium, potassium, sulfate, creatinine, and citrate were significantly lower in patients with Crohn’s disease. Intestinal oxalate absorption, the fractional and 24 h urinary oxalate excretion, and the risk of calcium oxalate stone formation were significantly higher in patients with urolithiasis than in patients without urolithiasis or in healthy controls. Regardless of the group, between 83% and 96% of the [13C2]oxalate was detected in the urine within the first 12 h after ingestion. The length of ileum resection correlated significantly with the intestinal absorption and urinary excretion of oxalate. These findings suggest that enteric hyperoxaluria can be attributed to the hyperabsorption of oxalate following extensive ileal resection. Oral supplementation of calcium and magnesium, as well as alkali citrate therapy, should be considered as treatment options for urolithiasis.

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Section: Discussionmentioning

confidence: 99%

Intestinal Oxalate Absorption, Enteric Hyperoxaluria, and Risk of Urinary Stone Formation in Patients with Crohn’s Disease

Siener,

Ernsten,

Speller

et al. 2024

Nutrients

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“…Diet composition may affect acid–base balance in humans by providing acid or base precursors [ 1 , 2 , 3 ]. Diets abundant in alkalizing plant foods may decrease the dietary acid load (DAL), whereas acidifying foods including eggs, meat and cheese may increase it [ 1 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Plant-Based Diets on Dietary Acid Load Metrics in Venezuela: A Cross-Sectional Study

Ekmeiro-Salvador

Storz

2023

Nutrients

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Dietary acid load (DAL) is an important determinant of the acid–base balance in humans and has been associated with several chronic non-communicable diseases. Plant-based diets, including vegetarian and vegan diets, decrease DAL—although their alkalizing potential varies substantially. Their net effect on common DAL scores, including potential renal acid load and net endogenous acid production, has been insufficiently quantified and is poorly understood—particularly in populations outside of Europe and North America. We assessed the associations between three plant-based dietary patterns (flexitarian vs. lacto-ovo-vegetarian vs. vegan diet) and DAL scores in a healthy Venezuelan population in the metropolitan area of Puerto La Cruz, Venezuela. Substantial differences in DAL scores were observed, whereby the vegan diet yielded the highest alkalizing potential, followed by the lacto-ovo-vegetarian and the flexitarian diet. DAL scores were substantially lower in comparison to European and North American plant-based populations, probably due to the higher potassium intake (exceeding 4000 mg/d in vegans), the higher magnesium intake (390.31 ± 1.79 mg/d in vegans) and the lower intake of protein in vegans and lacto-ovo-vegetarians. Additional studies in other non-industrialized populations are warranted to allow for a better understanding of the (numeric) impact of plant-based dietary patterns on DAL scores, potentially allowing for an establishment of reference ranges in the near future.

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Urinary acid-base excretion deciphers high acid load from colonic bicarbonate loss in intestinal failure patients with ileocolonic anastomosis – Guidance for composition of parenteral support

Foerster,

Lamprecht,

Rischmüller

et al. 2024

Clinical Nutrition

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Neglected analytes in the 24-h urine: ammonium and sulfate

Cited by 11 publications

References 41 publications

Intestinal Oxalate Absorption, Enteric Hyperoxaluria, and Risk of Urinary Stone Formation in Patients with Crohn’s Disease

Intestinal Oxalate Absorption, Enteric Hyperoxaluria, and Risk of Urinary Stone Formation in Patients with Crohn’s Disease

The Impact of Plant-Based Diets on Dietary Acid Load Metrics in Venezuela: A Cross-Sectional Study

Urinary acid-base excretion deciphers high acid load from colonic bicarbonate loss in intestinal failure patients with ileocolonic anastomosis – Guidance for composition of parenteral support

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