Neohesperidin inhibits cardiac remodeling induced by Ang II in vivo and in vitro

Zhang, Jingsi; Fu, Xiaodan; Li, Yang; Wen, Hong‐xing; Zhang, Lijiao; Liu, Fengyi; Lou, Yu; Yang, Qian; Ding, Yanchun

doi:10.1016/j.biopha.2020.110364

Cited by 15 publications

(10 citation statements)

References 28 publications

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“…It has been demonstrated recently that the neohesperidin inhibited Angiotensin II-induced myocardial contractile dysfunction, and reduced hypertension, myocardial hypertrophy, fibrosis, SOD production, and inflammation (Zhang et al, 2020).…”

Section: Eriocitrinmentioning

confidence: 99%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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Citrus is the most cultivated fruit crop in the world and occupies a place of considerable importance in the country’s economy. Almost 33% of the citrus fruits are processed for juice production; however, a great amount of wastes, including peels, segment membranes, and seeds are also produced. Indeed, citrus fruits consist of 45% juice, 26% pulp, 27% peels, and 2% seeds. Pruning, a cultural practice involving the removal of tree branches and limbs, was applied to improve fruit’s quality. A large amount of leaves are produced through pruning. These agri-food matrices contain a wide range of bioactive phytochemicals compared to fruits. The present review covers the past 5 years of research carried out in chemistry, health properties, and applications in food and nutraceutical industries of all portions of citrus fruit and its major bioactive compounds. Additionally, patents are also included.

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Section: Eriocitrinmentioning

confidence: 99%

Citrus species: Modern functional food and nutraceutical-based product ingredient

2021

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“…Flavonoids, which include, flavones, flavonols, flavan-3-ols, flavanones, isoflavanones, isoflavans, and pterocarpans, have diverse structures. Previous studies suggest that apigenin [ 35 ], chrysin [ 36 ], neohesperidin [ 37 ], epicatechin [ 38 ], catechin [ 39 ], and kaempferol [ 40 , 41 ] are bioactive substances that have antioxidant, antibacterial, antifungal, and antitumor activities and anti-inflammatory properties. Therefore, we believe that the flavonoids in C .…”

Section: Discussionmentioning

confidence: 99%

Transcriptome and metabolome reveal the accumulation of secondary metabolites in different varieties of Cinnamomum longepaniculatum

et al. 2022

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Background Cinnamomum longepaniculatum (Gamble) N. Chao ex H. W. Li, whose leaves produce essential oils, is a traditional Chinese medicine and economically important tree species. In our study, two C. longepaniculatum varieties that have significantly different essential oil contents and leaf phenotypes were selected as the materials to investigate secondary metabolism. Result The essential oil content and leaf phenotypes were different between the two varieties. When the results of both transcriptome and metabolomic analyses were combined, it was found that the differences were related to phenylalanine metabolic pathways, particularly the metabolism of flavonoids and terpenoids. The transcriptome results based on KEGG pathway enrichment analysis showed that pathways involving phenylpropanoids, tryptophan biosynthesis and terpenoids significantly differed between the two varieties; 11 DEGs (2 upregulated and 9 downregulated) were associated with the biosynthesis of other secondary metabolites, and 12 DEGs (2 upregulated and 10 downregulated) were related to the metabolism of terpenoids and polyketides. Through further analysis of the leaves, we detected 196 metabolites in C. longepaniculatum. The abundance of 49 (26 downregulated and 23 upregulated) metabolites differed between the two varieties, which is likely related to the differences in the accumulation of these metabolites. We identified 12 flavonoids, 8 terpenoids and 8 alkaloids and identified 4 kinds of PMFs from the leaves of C. longepaniculatum. Conclusions The combined results of transcriptome and metabolomic analyses revealed a strong correlation between metabolite contents and gene expression. We speculate that light leads to differences in the secondary metabolism and phenotypes of leaves of different varieties of C. longepaniculatum. This research provides data for secondary metabolite studies and lays a solid foundation for breeding ideal C. longepaniculatum plants.

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“…The mice were divided into Sham, Neohesperidin, Ang II, Ang II + Neohesperidin (six mice in each group). Mice were infused with Ang II (490 ng/kg/min, Aladdin, Ca) by Alzetmodel 1,002 micropump for 2 weeks ( Zhang et al, 2020 ). A caudal vein injection of Neohesperidin (50 mg/kg/day) was performed for 16 days ( Lu et al, 2020 ).…”

Section: Methodsmentioning

confidence: 99%

“…Sections were stained with hematoxylin-eosin (H&E), Mason trichrome staining, immunofluorescence (CD68 antibody, 1:100, Zen-bio) and Dihydroethidium (DHE). The positive regions were analyzed using ImageJ ( Zhang et al, 2020 ).…”

Section: Methodsmentioning

confidence: 99%

“…Neohesperidin is a flavonoid compound and is abundant in cucurbitaceaeplaying an antioxidant and anti-inflammatory role ( Zhao et al, 2019 ; Li et al, 2021 ). We have reported that Neohesperidin could inhibit cardiac remodeling induced by Ang II in vivo and in vitro ( Zhang et al, 2020 ). The aim of this study was to investigate whether Neohesperidin could protect angiotensin II-inducedsmooth muscle thickening and endothelial injury by inhibiting oxidative stress, inflammation and fibrosis, thereby inhibiting vascular remodeling.…”

Section: Introductionmentioning

confidence: 99%

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Neohesperidin Protects Angiotensin II-Induced Hypertension and Vascular Remodeling

et al. 2022

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Vascular remodeling due to hypertension is one of the major health challenges facing countries around the world. Neohesperidin, a flavonoid glycoside found in citrus fruits, is an antioxidant. Neohesperidin has been studied for a variety of diseases in addition to hypertension. In this study, angiotensin II was used to induce hypertension in mice (490 ng/kg/min, 14 days). We used H&E, Masson, immunofluorescence, dihydroethidine and qPCR to evaluate the effect of Nehesperidin (50 mg/kg/day, 16 days) on pathological hypertension in mice. Estimating the effect of Nehesperidin on human umbilical vein endothelial cells and vascular smooth muscle cells stimulated by angiotensin II. We found that neohesperidin inhibited angiotensin II-induced hypertension in mice. Neohesperidin reduced angiotensin II-induced vascular hypertrophy, fibrosis, inflammation and oxidative stress in vivo. Neohesperidin inhibited angiotensin II-induced ROS and DNA damage in human umbilical vein endothelial cells. Neohesperidin inhibited angiotensin II-induced migration of vascular smooth muscle cells. The results showed that Nehesperidin acts as an antioxidant and could significantly inhibit angiotensin II induced hypertension and vascular remodeling in vitro and in vivo.

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Neohesperidin inhibits cardiac remodeling induced by Ang II in vivo and in vitro

Cited by 15 publications

References 28 publications

Citrus species: Modern functional food and nutraceutical-based product ingredient

Citrus species: Modern functional food and nutraceutical-based product ingredient

Transcriptome and metabolome reveal the accumulation of secondary metabolites in different varieties of Cinnamomum longepaniculatum

Neohesperidin Protects Angiotensin II-Induced Hypertension and Vascular Remodeling

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