Neohesperidin Protects Angiotensin II-Induced Hypertension and Vascular Remodeling

Zhang, Jingsi; Hui, Yuanshu; Liu, Fengyi; Yang, Qian; Lü, Yi; Chang, Yeting; Liu, Qinlong; Ding, Yanchun

doi:10.3389/fphar.2022.890202

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…Accumulation of catalases attenuates the progression of vascular remodeling and hypertension by reducing oxidative stress. [300][301][302][303] Immunity/inflammation pathway The majority of components involved in the Immunity/inflammatory responses circulate through the blood and vasculature. And low-grade immune response plays an important role in the initiation and maintenance of elevated BP.…”

Section: Etcmentioning

confidence: 99%

Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

Yang

et al. 2023

Sig Transduct Target Ther

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Hypertension is a global public health issue and the leading cause of premature death in humans. Despite more than a century of research, hypertension remains difficult to cure due to its complex mechanisms involving multiple interactive factors and our limited understanding of it. Hypertension is a condition that is named after its clinical features. Vascular function is a factor that affects blood pressure directly, and it is a main strategy for clinically controlling BP to regulate constriction/relaxation function of blood vessels. Vascular elasticity, caliber, and reactivity are all characteristic indicators reflecting vascular function. Blood vessels are composed of three distinct layers, out of which the endothelial cells in intima and the smooth muscle cells in media are the main performers of vascular function. The alterations in signaling pathways in these cells are the key molecular mechanisms underlying vascular dysfunction and hypertension development. In this manuscript, we will comprehensively review the signaling pathways involved in vascular function regulation and hypertension progression, including calcium pathway, NO-NOsGC-cGMP pathway, various vascular remodeling pathways and some important upstream pathways such as renin-angiotensin-aldosterone system, oxidative stress-related signaling pathway, immunity/inflammation pathway, etc. Meanwhile, we will also summarize the treatment methods of hypertension that targets vascular function regulation and discuss the possibility of these signaling pathways being applied to clinical work.

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Section: Etcmentioning

confidence: 99%

Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

Yang

et al. 2023

Sig Transduct Target Ther

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“…Jurnal Teknologi Pertanian Andalas Vol. 27, No.1, Maret 2023, ISSN 1410-1920, EISSN 2579 Agung Yogeswara ================================================================================ 14 Kelompok flavanone yang dihasilkan pada ekstrak cair kental buah mengkudu dengan metode pengeringan diangin-anginkan dan dioven adalah 5,7-Dihydroxy-6,8-dimethyl-3-(3',4'dihydroxybenzyl)chroman-4-one yang memiliki potensi sebagai anti-mutagenik dan bermanfaat dalam pencegahan kanker (Lin et al, 2014) dan neohesperidin yang berfungsi sebagai antihipertensi yang menghambat angiotensin II agar tidak terjadinya kerusakan Reactive Oxygen Species (ROS) dan deoxyribonuleic acid (DNA) pada sel endotel vena umbilikalis manusia (Zhang et al, 2022). KESIMPULAN 1.…”

Section: B Kandungan Komponen Profil Senyawa Flavonoid Ekstrak Buah M...unclassified

PROFIL SENYAWA FLAVONOID EKSTRAK BUAH MENGKUDU (Morinda citrifolia L.) DENGAN BERBAGAI METODE PENGERINGAN

Dewi Landari,

Wita Kusumawati,

Nursini

et al. 2023

j. teknol. pertan. n.a.

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Buah mengkudu (Morinda citrifolia L.) diketahui memiliki kandungan senyawa flavonoid yang mempunyai manfaat sebagai antivirus, antioksidan, antijamur, anti inflamasi, dan antihipertensi. Tingginya kadar air pada buah mengkudu dapat mengakibatkan adanya perubahan secara biologi dan kimia, sehingga diperlukan alternatif proses pengeringan untuk mengurangi kadar air dan menjaga kandungan senyawa flavonoid. Penelitian ini bertujuan untuk untuk menganalisis kadar air dari bubuk buah mengkudu dengan berbagai metode pengeringan dan mengetahui profil senyawa flavonoid yang terdapat pada ekstrak buah mengkudu dengan berbagai metode pengeringan. Metode yang digunakan yaitu metode eksperimen dengan rancangan acak lengkap tiga perlakuan dan tiga ulangan sehingga di dapatkan 9 unit percobaan, dengan pengeringan buah mengkudu yaitu pengeringan matahari langsung, pengeringan diangin-anginkan dan pengeringan oven kemudian simplisia buah mengkudu dianalisis kadar airnya menggunakan metode gravimetri. Bubuk kering buah mengkudu dimaserasi menggunakan etanol 96%, kemudian dianalisis secara kualitatif menggunakan metode LCMS/MS QTOF. Berdasarkan penelitian didapatkan rata-rata kadar air bubuk buah mengkudu metode pengeringan matahari langsung, diangin-anginkan dan dioven berturut-turut adalah 12,64%, 14,11% dan 9,38%. Kandungan komponen profil senyawa flavonoid yang terdapat pada ekstrak buah mengkudu dengan metode pengeringan matahari langsung, metode pengeringan diangin-anginkan dan metode pengeringan oven berturut-turut yaitu sebanyak 9 senyawa flavonoid, 10 senyawa flavonoid dan 2 senyawa flavonoid.

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“…10 Recent reports have demonstrated that increases in AngII levels, particularly through the AngII type 1 receptor (AT-1R), induce tissue brosis in the heart, kidneys, liver, and vessels. [11][12][13][14][15] AngII receptors are expressed in the retina and sclera, and increased expression of AngII activates retinal cells and scleral broblasts. 16,17 One study showed that selectively inhibiting AT-1R with losartan decreases activation of the scleral broblasts after ocular hypertension and protects the RGCs.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin II-related activation of scleral fibroblasts and the role of retinal ganglion cell death in glaucoma

Kim

Shin

et al. 2023

Preprint

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We identify the angiotensin II (AngII)-associated changes in the extracellular matrix (ECM), and the biomechanical properties of the sclera after systemic hypotension. Systemic hypotension was induced by administering oral hydrochlorothiazide. AngII receptor levels and ECM components in the sclera and biomechanical properties were evaluated by stress–strain relationship after systemic hypotension. The effect of inhibiting the AngII receptor with losartan was determined in the systemic hypotensive animal model and the cultured scleral fibroblasts from this model. The effect of losartan on retinal ganglion cell (RGC) death was evaluated in the retina. Both AngII receptor type I (AT-1R) and type II (AT-2R) increased in the sclera after systemic hypotension. Proteins related to the activation of fibroblasts (transforming growth factor [TGF]-β1 and TGF-β2) indicated that transformation to myofibroblasts (αSMA), and the major ECM protein (collagen type I) increased in the sclera after systemic hypotension. These changes were associated with stiffening of the sclera in the biomechanical analysis. Administering losartan in the Tenon’s tissue significantly decreased the expression of AT-1R, αSMA, TGF-β, and collagen type I in the cultured scleral fibroblasts and the sclera of systemic hypotensive rats. The sclera became less stiff after the losartan treatment. A significant increase in the number of RGCs and decrease in glial cell activation was found in the retina after the losartan treatment. These findings suggest that AngII has a role in scleral fibrosis after systemic hypotension and that inhibiting AngII could modulate the tissue properties of the sclera resulting in the protection of RGCs.

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Neohesperidin Protects Angiotensin II-Induced Hypertension and Vascular Remodeling

Cited by 8 publications

References 27 publications

Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

PROFIL SENYAWA FLAVONOID EKSTRAK BUAH MENGKUDU (Morinda citrifolia L.) DENGAN BERBAGAI METODE PENGERINGAN

Angiotensin II-related activation of scleral fibroblasts and the role of retinal ganglion cell death in glaucoma

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