Neonatal gipertireotropinemiya – an indicator of the severity of iodine deficiency in the population?

Суплотова, Л. А.; Александровна, Суплотова Людмила; Макарова, О. Б.; Борисовна, Макарова Ольга; Kovalzhina, Larisa Sergeevna; Сергеевна, Ковальжина Лариса

doi:10.14341/ket2015347-53

Cited by 8 publications

(2 citation statements)

References 2 publications

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“…В то же время мКЙМ у БЖ возросла с 93 мкг/л в 1999 г. до 124 мкг/л в 2009 г. [9]. В этом примере повышенную частоту ТТГ можно хотя бы отчасти объяснить неадекватной йодной обеспеченностью (мКЙМ меньше 150 мкг/л).…”

Section: совершенствование системы мониторинга йодного статуса населенияunclassified

Armenia's experience in achieving an adequate iodine status of the population

Gerasimov

Hutchings

Aslanyan³

et al. 2021

Clin Exp Thyroid

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Armenia was one of the first post-Soviet countries, that after a relatively short break has restored the production of iodized salt at the beginning of the 2000s, and in 2004 adopted a decree that made the production and import of iodized salt mandatory, as well as its use in the food industry. A 2016 national survey showed high sustainability of the iodine prophylaxis program in Armenia – median urinary iodine concentration (UIC) in schoolchildren and pregnant women (PW) was in the optimal range (242 and 226 μg/l, respectively), and coverage of households with quality iodized salt was 95%. In addition to iodized salt used in households, more than 50% of iodine was consumed with processed foods, primarily bakery products. An essential advantage of the iodine prophylaxis program in Armenia is that it provides adequate iodine status not only for the general population, but also for PW. At the same time about 37% of PW used iodine supplements, which were not necessary. The experience of Armenia shows that the analysis of screening datasets for neonatal hypothyroidism screening makes it possible to efficiently and at minimal cost annually evaluate the iodine status of the population. And if the frequency of TSH levels > 5 mIU/L exceeds 3%, the health authorities should consider this as an alarm and conduct a more detailed assessment to find out the cause of the iodine status insufficiency and take appropriate measures

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Section: совершенствование системы мониторинга йодного статуса населенияunclassified

Armenia's experience in achieving an adequate iodine status of the population

Gerasimov

Hutchings

Aslanyan³

et al. 2021

Clin Exp Thyroid

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“…The most common alimentary-dependent diseases in Russia, as in many other countries, are diseases associated with iodine deficiency in the diet. The problem of iodine deficiency in the diet is "historical", since the first scientific data on the effect of iodine deficiency on ADD formation were indicated in the literature at the beginning of the XX century [4,5,6]. According to nutritionists and in the areas of forecasting the scientific research prospects in the field of nutrition and health, the issues of iodine deficiency and ways to reduce it occupy a leading position [1].…”

Section: Introductionmentioning

confidence: 99%

Expanding the knowledge base on actual nutrition as an element of the system of alimentary-dependent diseases prevention

et al. 2020

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The work presents a multi-aspect model of alimentary-dependent diseases (ADD) prevention, which demonstrates the participants in this process and their priority tasks. A method is proposed based on the use of indicators for assessing the iodine-containing products contribution to the nutritional value of diets. Calculations were performed on a micronutrient - iodine, the deficiency of which causes the most common by depth and width ADD - thyroid pathology. To assess the iodine replenishing potential of raw fish and non-fish sea foods with the human diet, indicators were developed that account along with the iodine content in 100 g of product, the factors that directly or indirectly affect the digestibility and the economic feasibility of some of the most in-demand fish varieties. Selected factors: native iodine content in the product; qualitative and quantitative composition of synergistic nutrients for its digestibility in the body. Deviations of the reference data on the content of iodine in fish and non-fish products were found, which on average amounted to about 45 %, which is a significant loss that must be taken into account when using the calculated method of actual nutrition study.

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Neonatal thyrotropin - indicatior of monitoring of iodine deficiency severity. What’s level is considered a «cutoff point»?

Суплотова

Макарова

Troshina

2022

Probl Endokrinol (Mosk)

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BACKGROUND: The issues of monitoring the effectiveness of iodine deficiency prevention programs are an important component in the process of iodine elimination. Neonatal thyrotropin (TSH) has been used as a criterion for the severity of iodine deficiency since 1994, however, the question of the “cut-off point” of the neonatal TSH level has been widely discussed in the recent literature.AIM: Evaluate the criterion for neonatal hyperthyroidism above 5 mIU/l from the perspective of monitoring iodine deficiency and establish a «cut-off point» on the model of healthy pregnant women with adequate iodine status.MATERIALS AND METHODS: A prospective study was conducted in a population of pregnant women in the city of Tyumen, with the formation of observation groups according to the level of iodine excretion in the urine — the main group (with adequate iodine status throughout the entire gestation period) and the comparison group (women with iodine levels less than 150 μg/l). The results of neonatal screening for congenital hypothyroidism in children of women participating in the study were evaluated. The frequency of neonatal TSH above 5mIU/l was assessed in the observation groups. ROC-analysis was performed and a «cut-off point» of the level of neonatal TSH was established as an indicator of iodine deficiency.RESULTS: The median urinary iodine concentration in the population of pregnant women in Tyumen was 159.05 μg/l, the incidence of goiter was 0.38%, the incidence of neonatal hyperthyroidism above 5 mIU/l was 2.88%, which characterizes adequate iodine intake in the pregnant population women. The frequency of neonatal TSH above 5 mIU/l in newborns from women from the main group was 1.47%, and in the comparison group — 9.3% (p = 0.076). ROC analysis revealed a threshold value of neonatal TSH of 2.77 mIU/l at the cut-off point, which corresponded to the highest value of the Youden index. Urinary iodine concentrations greater than 150 μg/l were predicted for nTSH values below this value.CONCLUSION: Analysis of databases of neonatal screening for congenital hypothyroidism makes it possible to effectively, quickly and at minimal cost annually assess the iodine status in the population. The established «cut-off point» of neonatal TSH in the model of healthy pregnant women with adequate iodine intake in our work is 2.77 mIU/l, the absence of statistically significant differences in the incidence of neonatal hyperthyroidism above 5 mIU/l from women with different iodine status during pregnancy indicate the need to revise the existing threshold of 5 mIU/l and may be an incentive to conduct large-scale studies in regions with different iodine supply.

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Neonatal gipertireotropinemiya – an indicator of the severity of iodine deficiency in the population?

Cited by 8 publications

References 2 publications

Armenia's experience in achieving an adequate iodine status of the population

Armenia's experience in achieving an adequate iodine status of the population

Expanding the knowledge base on actual nutrition as an element of the system of alimentary-dependent diseases prevention

Neonatal thyrotropin - indicatior of monitoring of iodine deficiency severity. What’s level is considered a «cutoff point»?

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