Neonatal sex and weight influence CD34+ cell concentration in umbilical cord blood but not stromal cell–derived factor 1-3′A polymorphism

Bijou, Fontanet; Ivanović, Zoran; Fizet, D; Dazey, Bernard; Boiron, Jean‐Michel; Lafarge, Xavier

doi:10.1016/j.jcyt.2014.09.002

Cited by 11 publications

(15 citation statements)

References 26 publications

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“…Female newborns seemed to result in a greater amount of TNCs, mostly polynuclear cells, 10,17,19,20,24,29,31,32,34,37,40,48,58 while male newborns presented an increase volume, CD341 cell amount, and CFU amount compared to female. 12,17,22,26,32,34,38,40,58 The explanation for this is simple as male weight is higher than female weight, 20,22,31 thus increasing the UCB collected volume, hence the cell amounts. Aroviita and coworkers 58 showed that when newborns have the same weight, males have better CFU amount.…”

Section: Newborn Sexmentioning

confidence: 90%

“…Most studies showed no significant impact in terms of sex. Female newborns seemed to result in a greater amount of TNCs, mostly polynuclear cells, while male newborns presented an increase volume, CD34+ cell amount, and CFU amount compared to female . The explanation for this is simple as male weight is higher than female weight, thus increasing the UCB collected volume, hence the cell amounts.…”

Section: Highlighted Factorsmentioning

confidence: 95%

“…The number of previous births had a negative correlation effect on volume for two articles, 12,18 but a positive correlation for one. 31 Regarding TNC counts, seven articles have reported negative correlation 11,12,17,19,34,35,43 and one article reported positive correlation. 59 Regarding CD341 cells, four articles showed that the first birth may be better than the next.…”

Section: Number Of Previous Birthsmentioning

confidence: 99%

“…Maternal age at delivery has been analyzed in 28 of 71 articles . In most articles, no significant correlation was found with UCB volume, TNCs, CD34+ cells, or CFU (Fig.…”

Section: Highlighted Factorsmentioning

confidence: 99%

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Associated factors of umbilical cord blood collection quality

et al. 2017

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After 30 years of hematopoietic stem cell use for various indications, umbilical cord blood is considered as an established source of cells with marrow and postmobilization peripheral blood. The limited number of cells still remains a problematic element restricting their use, especially in adults who require to be grafted with a higher cell number. Improving the quality of harvested cord blood, at least in terms of volume and amount of cells, is essential to decrease the number of discarded units. In this review, we examine several variables related to parturient, pregnancy, labor, delivery, collection, the newborn, umbilical cord, and placenta. We aim to understand the biologic mechanisms that can impact cord blood quality. This knowledge will ultimately allow targeting donors, which could provide a rich graft and improve the efficiency of the collection.

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Section: Newborn Sexmentioning

confidence: 90%

Section: Highlighted Factorsmentioning

confidence: 95%

Section: Number Of Previous Birthsmentioning

confidence: 99%

“…Maternal age at delivery has been analyzed in 28 of 71 articles . In most articles, no significant correlation was found with UCB volume, TNCs, CD34+ cells, or CFU (Fig.…”

Section: Highlighted Factorsmentioning

confidence: 99%

See 2 more Smart Citations

Associated factors of umbilical cord blood collection quality

et al. 2017

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show abstract

“…Neonatal factors also contribute to UCB‐SC quality and quantity. For example, birth weight has been shown to be the strongest predictor of TNC counts (Manegoldbrauer et al, ), and females tend to have greater TNC counts while males tend to have greater volumes of UCB and greater numbers of hematopoietic stem cells and CFUs (Ballen et al, ; Bijou et al, ).…”

Section: Sources Of Ucb‐scs In Preterm Infantsmentioning

confidence: 99%

Umbilical cord blood stem cell therapy in premature brain injury: Opportunities and challenges

Peng

Shi

et al. 2019

J of Neuroscience Research

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Preterm birth and associated brain injury are the primary cause of cerebral palsy and developmental disabilities and are among the most serious global health issues that modern society faces. Current therapy for infants suffering from premature brain injury is still mainly supportive, and there are no effective treatments. Thus there is a pressing need for comparative and translational studies on how to reduce brain injury and to increase regeneration and brain repair in preterm infants. There is strong supporting evidence for the use of umbilical cord blood (UCB)‐derived stem cell therapy for treating preterm brain injury and neurological sequelae. UCB‐derived stem cell therapy is effective in many animal models and has been shown to be feasible in clinical trials. Most of these therapies are still experimental, however. In this review, we focus on recent advances on the efficacy of UCB‐derived stem cell therapy in preterm infants with brain injury, and discuss the potential mechanisms behind their therapeutic effects as well as application strategies for future preclinical and clinical trials.

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The effect of maternal and infant factors on cord blood yield

Mousavi

Abroun

Zarrabi

et al. 2016

Pediatr Blood Cancer

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Umbilical cord blood (CB) can be used as an alternative hematopoietic stem cell source for transplantation in hematological malignancy and blood disorders. The success of transplantation is highly related to the levels of total nucleated cell and CD34 cell counts. The evaluation of optimal conditions can decrease the rate of graft rejection due to low cell count and increases the quality of CB units (CBUs) in the blood bank and the success rate of engraftment. To this end, we review the maternal and infant parameters affecting the quality and quantity of CBUs.

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Neonatal sex and weight influence CD34+ cell concentration in umbilical cord blood but not stromal cell–derived factor 1-3′A polymorphism

Cited by 11 publications

References 26 publications

Associated factors of umbilical cord blood collection quality

Associated factors of umbilical cord blood collection quality

Umbilical cord blood stem cell therapy in premature brain injury: Opportunities and challenges

The effect of maternal and infant factors on cord blood yield

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