Neonatal thrombocytopenia and platelets transfusion

Gupta, Anil K.; Kumari, Sneha; Singhal, Abhishek; Bahl, Aruna

doi:10.4103/0973-6247.98924

Cited by 15 publications

(18 citation statements)

References 15 publications

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“…Thrombocytopenia affects up to 20-50% of all neonates admitted in neonatal intensive care unit [20]. In our study prevalence of thrombocytopenia was 38% which was similar to other studies [21,22]. Charoo BA [23] observed that 27% of babies with sepsis developed mild, 20% moderate and 12.5% developed severe thrombocytopenia.…”

Section: Discussionsupporting

confidence: 89%

Correlation of platelet count and platelet indices with neonatal sepsis-diagnostic and prognostic indicator

et al. 2017

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Introduction: To evaluate variations in platelet count and platelet indices-mean platelet volume (MPV) and platelet distribution width (PDW) in neonatal sepsis. Methodology: This study was conducted over a period of one year in Neonatal Intensive Care Unit of Mata Chanan Devi Hospital, New Delhi. Neonates with confirmed as well as probable sepsis were included in the study. Platelet count, MPV and PDW were monitored three times: at diagnosis (1 st day), 3 rd day and 7 th day of sepsis. Results: Among 100 cases, culture proven sepsis was present in17 neonates. Fungal sepsis occurred in 2 cases (11.76%), 7 neonates (41.18%) had gram positive sepsis and 8 neonates (47.06%) had gram negative sepsis. Thrombocytopenia was present in 38% and thrombocytosis in 6% cases. Mild thrombocytopenia was noted in 55.26%, moderate thrombocytopenia in 31.58% and severe thrombocytopenia in 13.16% babies. Culture positive neonates had high prevalence of thrombocytopenia. High mortality was found in moderate to severe thrombocytopenic neonates, and these babies also had high MPV and high PDW. Conclusions: Thrombocytopenia was more common than thrombocytosis in neonatal sepsis. Prevalence of thrombocytopenia was significantly high in culture proven sepsis (64.7%). There was statistically significant difference in mean platelet count on day 1, day 3 and day 7 of sepsis among culture positive and culture negative neonatal sepsis. Neonates with culture proven sepsis had high MPV on day 7 and high PDW on day 1 of sepsis. There was high MPV and high PDW in neonates who developed thrombocytopenia and also in expired babies. Platelet count and platelet indices can be used as early diagnostic and prognostic biomarkers for neonatal sepsis.

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Section: Discussionsupporting

confidence: 89%

Correlation of platelet count and platelet indices with neonatal sepsis-diagnostic and prognostic indicator

et al. 2017

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“…prevalence of thrombocytopenia among hospitalized neonates was between 22 -35% in other studies [32][33][34][35][36][37][38][39]. It was between 15-20% in studies by Khalessi N et al [7], Gupta et al [40], Anil K Gupta et al [22], Qazi Iqbala b et al [20]. However a higher prevalence of 69.9% was noted by Kyoung Hee Choi et al [41] & 53% by Zaccheaus A Jeremiah et al [5].…”

Section: Prevalence Of Culture Positivitymentioning

confidence: 94%

Prevalence and Course of Thrombocytopenia in Culture Positive and Culture Negative Neonatal Sepsis

Rabindran¹,

Parakh²,

K³

et al. 2014

Int J Pediatr Res

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Introduction: Neonatal Sepsis is commonly associated with thrombocytopenia. Objective: To assess the prevalence and course of thrombocytopenia in culture positive and culture negative neonatal sepsis in comparison to normal newborns. Methods: This is a retrospective case analysis of 533 neonates between January-2012 to December-2014. The parameters examined were Baseline Platelet Count, Change In Platelet Count, (Baseline Platelet Count-Change In Platelet Count)/ Baseline Platelet Count, Platelet Nadir, Incidence, Duration & Severity of Thrombocytopenia. Statistical Analysis: All data were collected in validated preformatted proforma sheet & analysed using appropriate statistical methods. Results: Among 533 neonates, 21.2% had Culture negative sepsis, 9.75% had culture positive sepsis & 69.04% had no sepsis. The prevalence of early onset sepsis was 17.44% & late onset sepsis was 13.50%. About 24.76% babies had thrombocytopenia; 9.56% had mild thrombocytopenia, 10.13% had moderate & 5.06% had severe thrombocytopenia. Late onset sepsis was associated with significant thrombocytopenia. Culture positive sepsis had significant drop in platelets with lower platelet nadir, higher incidence, more severe & prolonged thrombocytopenia compared to culture negative sepsis & normal neonates. Conclusion: There are quantitative differences in the platelet response to neonatal sepsis, particularly to culture positive sepsis. Hematological changes in platelet count induced by culture proven and culture negative neonatal sepsis can be used to make an early diagnosis and prompt management of neonatal sepsis.

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“…Decreased platelet count is particulraly due to hematologic disorders. [1][2][3] Other causes of thrombocytopenia include pre-eclampsia, HELLP syndrome and ITP. This disease affects 6% to 15% of all pregnant women usually at the end of pregnancy and is moderate.…”

Section: Introductionmentioning

confidence: 99%

Risk factors and fetomaternal outcome in pregnancy with thrombocytopenia.

Qureshi¹,

Sakina²,

Taqi³

et al. 2019

TPMJ

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Objectives: To find out the risk factors and their effects on mother and fetus in pregnancy with thrombocytopenia. Study Design: Cross sectional study. Setting: Department of Obstetrics and Gynaecology at Liaquat University Hospital Hyderabad. Period: Six months (1st July 2016 to 31st December 2016). Material and Methods: Total 96 patients with gestational age >24 weeks having platelet count below 150X109/L were included in the study. Patients admitted throughout patient clinic department of obstetrics & Gynecology at Liaqat University Hospital. Those patients having platelet count below 150X109/L were registered for study. Proforma filled which include Patients demographics details, gestational age, complete blood count (Having platelet count) other important investigations like coagulation profile (PT, APTT), Ultrasound and LFT noted in proforma SPSS version used for analysis. Descriptive statics were calculated frequency and percentages were drawn for the study. Results: Risk factors related to thrombocytopenia included PIH18 (18.8%), preeclampsia 14(14.6%), eclampsia 10(10.3%), HELLP Syndrome 6(6.3%), Viral Hepatitis 12(12.5%) and in 36(37.5%) no risk factors was found. Maternal complication were placental abruption21 (21.8%) post partam hemorrhage 14(14.6%). 7(7.3%) were transferred to ICU and 02(2.1%) maternal death was seen. Fetal outcome include low Apgar score of <6 in 17(17.7%), low birth weight 16(16.7%) and NICU admission 11(11.5%). Conclusion: Thrombocytopenia is a common finding in pregnancy careful diagnosis is important to distinguish serious causes from mild then to manage mother and fetus appropriately. Thrombocytopenia in pregnancy is associated with adverse maternal and fetal outcome in significant number of pregnant woman.

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Neonatal thrombocytopenia and platelets transfusion

Cited by 15 publications

References 15 publications

Correlation of platelet count and platelet indices with neonatal sepsis-diagnostic and prognostic indicator

Correlation of platelet count and platelet indices with neonatal sepsis-diagnostic and prognostic indicator

Prevalence and Course of Thrombocytopenia in Culture Positive and Culture Negative Neonatal Sepsis

Risk factors and fetomaternal outcome in pregnancy with thrombocytopenia.

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