Nephritis‐associated plasmin receptor in the cutaneous vessels in <scp>IgA</scp> vasculitis

Miyabe, Chie; Oda, Takashi; Miyata, Ryujin; Miyabe, Yoshishige; Ishiguro, Naoko

doi:10.1111/1346-8138.16574

Cited by 3 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NAPlr immunoreactivity has been observed in the glomeruli of patients with IgAV with nephritis (34). Recently, we demonstrated that NAPlr was positive in 75.0% of skin tissues derived from patients with IgAV (14). NAPlr immunoreactivity was detected around small dermal vessels, and its distribution was similar to the area where plasmin activity was observed, suggesting that NAPlr-positive perivascular deposits may trigger neutrophil infiltration in IgAV (14).…”

Section: Iga Vasculitismentioning

confidence: 58%

“…Recently, we demonstrated that NAPlr was positive in 75.0% of skin tissues derived from patients with IgAV (14). NAPlr immunoreactivity was detected around small dermal vessels, and its distribution was similar to the area where plasmin activity was observed, suggesting that NAPlr-positive perivascular deposits may trigger neutrophil infiltration in IgAV (14). Similar to several other vascular disorders, anti-endothelial cell antibodies (AECA) have been detected in patients with IgAV (35).…”

Section: Iga Vasculitismentioning

confidence: 80%

“…Autoimmune diseases can affect virtually every organ in the body, including the heart, blood vessels, skin, joints, kidneys, and central nervous system (10,11). The association between autoimmune diseases and microbes has been widely reported (12)(13)(14). For example, immunoglobulin (Ig)A vasculitis (IgAV) is often triggered by a prior infection, such as an upper respiratory tract infection caused by various microorganisms, including Streptococcus, S. aureus, and varicella-zoster virus (13).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Streptococcal infection and autoimmune diseases

Ohashi,

Murayama,

Miyabe

et al. 2024

Front. Immunol.

Self Cite

View full text Add to dashboard Cite

Excessive activation of immune cells by environmental factors, such as infection or individual genetic risk, causes various autoimmune diseases. Streptococcus species are gram-positive bacteria that colonize the nasopharynx, respiratory tract, gastrointestinal tract, genitourinary tract, and skin. Group A Streptococcus (GAS) species cause various symptoms, ranging from mild infections, such as tonsillitis and pharyngitis, to serious infections, such as necrotizing fasciitis and streptococcal toxic shock syndrome. The contribution of GAS infections to several autoimmune diseases, including acute rheumatic fever, vasculitis, and neuropsychiatric disorders, has been studied. In this review, we focus on the association between streptococcal infections and autoimmune diseases, and discuss current research on the mechanisms underlying the initiation and progression of autoimmune diseases.

show abstract

Section: Iga Vasculitismentioning

confidence: 58%

Section: Iga Vasculitismentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Streptococcal infection and autoimmune diseases

Ohashi,

Murayama,

Miyabe

et al. 2024

Front. Immunol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…With regard to cutaneous small vessel vasculitis (CSVV), previously reported cause of the disease includes infections (20%), inflammatory conditions (15% to 20%), drug reactions (10% to 15%), or malignancies (5%), and the remaining half of CSVV cases are considered to be idiopathic 6 . We previously showed that a streptococcal antigen, the nephritis-associated plasmin receptor, is deposited in cutaneous vessels in IgA vasculitis, possibly inducing vascular inflammation 7 . Polyarteritis nodosa (PAN) is triggered by hepatitis B virus (HBV) infection 8 , and HBV on the vascular wall has been identified at the site of vasculitis 9 , suggesting that the pathogen may directly induce some types of vasculitis.…”

Section: Introductionmentioning

confidence: 99%

Alteration of microbial composition in the skin and blood in vasculitis

Miyata,

Miyabe,

Oki

et al. 2023

Sci Rep

Self Cite

View full text Add to dashboard Cite

Vasculitis is a systemic autoimmune disease characterized by leukocyte infiltration into blood vessels. Various microorganisms have been associated with the pathogenesis of vasculitis; however, the causal microbial agents and underlying mechanisms are not fully understood, possibly because of the technical limitations of pathogen detection. In the present study, we characterized the microbiome profile of patients with cutaneous vasculitis using comprehensive metagenome shotgun sequencing. We found that the abundance of the SEN virus was increased in the affected skin and serum of patients with vasculitis compared to healthy donors. In particular, the abundance of SEN virus reads was increased in the sera of patients with cutaneous arteritis. Among the bacteria identified, Corynebacteriales was the most differentially associated with vasculitis. Linear discriminant analysis effect size also indicated differences in the microbial taxa between patients with vasculitis and healthy donors. These findings demonstrate that vasculitis is associated with considerable alteration of the microbiome in the blood and skin and suggest a role for the infectious trigger in vasculitis.

show abstract