Nephropathy in Remnant Kidneys: Pathological Proteinuria After Unilateral Nephrectomy

Lent, V.; Harth, Judy

doi:10.1016/s0022-5347(17)32727-1

Cited by 18 publications

(6 citation statements)

References 13 publications

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“…Our study, in addition to some previous studies, demonstrated that nephrectomized patients have proteinuria (Lenth & Harth, 1994). In addition, correlations were found between proteinuria and IGF-1 and IGFBP-3 levels.…”

Section: Discussionsupporting

confidence: 85%

IGF‐1, IGFBP‐3, VEGF and MMP‐9 levels and their potential relationship with renal functions in patients with compensatory renal growth

Yıldız

Kural

Çolak

et al. 2007

Clin Physio Funct Imaging

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Section: Discussionsupporting

confidence: 85%

IGF‐1, IGFBP‐3, VEGF and MMP‐9 levels and their potential relationship with renal functions in patients with compensatory renal growth

Yıldız

Kural

Çolak

et al. 2007

Clin Physio Funct Imaging

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“…However, NX did not lead to a further increase in glomerular volume in C57 Os/؉ mice. We make three conclusions: 1) sclerosis was more severe in the ROP strain when nephron reduction occurred in utero; 2) the absence of glomerulosclerosis in C57 mice was not related to a higher threshold for a sclerosis response Because the shortage of cadaver kidneys has prompted an increase in the use of kidneys from living donors for transplantation, 1 it is important to know whether this practice places donors at risk.2-6 Many, 5,6 but not all, [2][3][4] retrospective studies have demonstrated that adult donors do not have a significant decline of renal function in follow-up periods of up to 45 years. It is possible that the risk to the donor depends on their susceptibility to a reduction in renal mass.…”

mentioning

confidence: 87%

Nature and Severity of the Glomerular Response to Nephron Reduction Is Strain-Dependent in Mice

Esposito

Striker

et al. 1999

The American Journal of Pathology

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Nephron reduction is an important factor in the development of glomerulosclerosis. In a study of the oligosyndactyly (Os) mutation that causes a congenital 50% reduction in nephron number , we previously found that ROP Os/؉ mice developed glomerulosclerosis whereas C57B1/6J Os/؉ mice did not. We concluded that the predisposition to glomerulosclerosis depended largely on the genetic background , the ROP being sclerosis-prone whereas the C57 strain was sclerosis-resistant. In the current experiments we asked whether the intensity of the sclerotic response to nephron reduction in the ROP strain was related to the time at which it occurred , ie , a pre-or post-natal event. We also determined whether the absence of lesions in C57 Os/؉ mice was caused by a higher threshold for the induction of a sclerotic response in C57 mice. We further examined the relationship between glomerular hypertrophy and sclerosis. C57 ؉/؉, C57 Os/؉, ROP ؉/؉, and ROP Os/؉ mice were uninephrectomized (NX) at age 10 weeks and followed for 8 weeks. We found no sclerotic changes in NX C57 ؉/؉ and C57 Os/؉ mice , despite a 75% reduction in nephron number in the latter. In contrast, both NX ROP ؉/؉ and NX ROP Os/؉ mice had glomerulosclerosis , which was more severe in the NX ROP Os/؉ mice. Examination of extracellular matrix synthesis and degradation at the mRNA level revealed that synthesis exceeded degradation in ROP Os/؉ mice. The lesions in NX ROP ؉/؉ were less severe than in sham-operated ROP/Os mice , suggesting that the timing of nephron reduction affected the amplitude of the sclerotic response in this strain. Following NX , an increase in glomerular volume was found in C57 ؉/؉, ROP ؉/؉, and ROP Os/؉ mice. However, NX did not lead to a further increase in glomerular volume in C57 Os/؉ mice. We make three conclusions: 1) sclerosis was more severe in the ROP strain when nephron reduction occurred in utero; 2) the absence of glomerulosclerosis in C57 mice was not related to a higher threshold for a sclerosis response in this strain; and 3) whereas glomerular size continued to increase as nephron number decreased in ROP mice, it reached a plateau in C57 mice. (Am J Pathol 1999, 154:891-897)Because the shortage of cadaver kidneys has prompted an increase in the use of kidneys from living donors for transplantation, 1 it is important to know whether this practice places donors at risk. 2-6 Many, 5,6 but not all, [2][3][4] retrospective studies have demonstrated that adult donors do not have a significant decline of renal function in follow-up periods of up to 45 years. It is possible that the risk to the donor depends on their susceptibility to a reduction in renal mass. In fact, patients undergoing unilateral nephrectomy who have a family history of renal disease and hypertension appear to carry a higher risk of long-term renal insufficiency than those without familial antecedents. 7 There is increasing evidence that genetic factors play an important role in the development of a large number of glomerular diseases. 8 -10 Furthermore, we recentl...

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“…Several studies have shown that chronic hyperfiltration, driven partly by an increase in glomerular pressure, leads to renal damage or an accelerated deterioration of preexisting renal damage. [ 6 7 8 9 10 11 12 ] On the other hand, multiple studies have demonstrated that LKD seems to be safe, and kidney function is well preserved in the long-term. [ 13 14 15 ] However, only a few studies are available regarding the changes of renal function after SN in the literature.…”

Section: Introductionmentioning

confidence: 99%

Deterioration in the renal function and risk of microalbuminuria after radical, simple and donor nephrectomy: A long-term outcome

et al. 2016

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Objectives:Evaluation of deterioration in renal function and risk of micro albuminuria after radical, simple and donor nephrectomy.Materials and Methods:A total of 594 patients underwent nephrectomy (159 radical, 318 simple and 117 donors) from February 2009 to December 2012 in our institute. First 300 eligible patients were divided in 3 groups, each having equalled number of patients. Group 1 was consisted of patients who underwent radical, group 2 had simple and group 3 had donor nephrectomy. These patients were followed up to February 2015. Follow up of all the patients were done at first month following the surgery and then in every six months subsequently. The follow up included the measurement of serum creatinine and urinary micro albumin in a spot urine sample. CKD-EPI equation was used for calculation of e GFR.Results:At the end of our study, 35 patients (41.6%) in group 1 and 8 patients (8.69%) in group 2 developed CKD stage 3. During the follow-up period, 41% patients in group 1, 13% in group 2 and 4% in group 3 developed MA.Conclusion:Nephron-sparing surgery should be the standard treatment of renal tumors, wherever possible. There should be a regular follow up of the patients after radical, simple and donor nephrectomy because of risk of CKD. Early consultation with nephrologists should be done by the patients who are suffering from MA after nephrectomy.

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Nephropathy in Remnant Kidneys: Pathological Proteinuria After Unilateral Nephrectomy

Cited by 18 publications

References 13 publications

IGF‐1, IGFBP‐3, VEGF and MMP‐9 levels and their potential relationship with renal functions in patients with compensatory renal growth

IGF‐1, IGFBP‐3, VEGF and MMP‐9 levels and their potential relationship with renal functions in patients with compensatory renal growth

Nature and Severity of the Glomerular Response to Nephron Reduction Is Strain-Dependent in Mice

Deterioration in the renal function and risk of microalbuminuria after radical, simple and donor nephrectomy: A long-term outcome

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