Nerve conduction block in diabetic rats using high-intensity focused ultrasound for analgesic applications

Lee, Y. F.; Lin, Chii Jeng; Cheng, Jung-Sung; Chen, G. S.

doi:10.1093/bja/aeu443

Cited by 33 publications

(27 citation statements)

References 28 publications

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“…High-intensity focused ultrasound was also used to suppress nerve conduction in rat studies [137,138]. Unfortunately, the specific parameters affecting the neuromodulation process, such as the extent and limits of thermally induced damage on nerves, have not been completely established.…”

Section: Focused Ultrasoundmentioning

confidence: 99%

Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review

Yildiz

Shin

Kaufman

2020

J NeuroEngineering Rehabil

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The field of prosthetics has been evolving and advancing over the past decade, as patients with missing extremities are expecting to control their prostheses in as normal a way as possible. Scientists have attempted to satisfy this expectation by designing a connection between the nervous system of the patient and the prosthetic limb, creating the field of neuroprosthetics. In this paper, we broadly review the techniques used to bridge the patient's peripheral nervous system to a prosthetic limb. First, we describe the electrical methods including myoelectric systems, surgical innovations and the role of nerve electrodes. We then describe non-electrical methods used alone or in combination with electrical methods. Design concerns from an engineering point of view are explored, and novel improvements to obtain a more stable interface are described. Finally, a critique of the methods with respect to their long-term impacts is provided. In this review, nerve electrodes are found to be one of the most promising interfaces in the future for intuitive user control. Clinical trials with larger patient populations, and for longer periods of time for certain interfaces, will help to evaluate the clinical application of nerve electrodes.

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Section: Focused Ultrasoundmentioning

confidence: 99%

Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review

Yildiz

Shin

Kaufman

2020

J NeuroEngineering Rehabil

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“…Stimulus parameters are dependent on many variables. There is a wide variation in stimulus parameters used specific to the researcher's needs and experimental techniques (Colucci, Strichartz, Jolesz, Vykhodtseva, & Hynynen, 2009;Foley, Little, & Vaezy, 2008;Gokin, Philip, & Strichartz, 2001;Lee, Lin, Cheng, & Chen, 2015).…”

Section: Of 33mentioning

confidence: 99%

Ex Vivo Whole Nerve Electrophysiology Setup, Action Potential Recording, and Data Analyses in a Rodent Model

Sun

Delgado

Behzadian³

et al. 2020

CP Neuroscience

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Ex vivo rodent whole nerves provide a model for assessing the effects of interventions on nerve impulse transmission and consequent sensory and/or motor function. Nerve impulse transmission can be measured through sciatic nerve compound action potential (CAP) recordings. However, de novo development and implementation of an ex vivo whole nerve resection protocol and an electrophysiology setup that retains nerve viability, that produces low noise CAP signals, and that allows for data analysis is challenging. Additionally, some of the existing literature lacks detail and accuracy and may be out of date. This article describes detailed protocols for rodent ex vivo sciatic nerve dissection and handling; importance of an optimal physiologic solution; computer‐aided designs for 3D printing of readily adaptable ex vivo rodent whole nerve electrophysiology chambers; construction of low‐cost, effective suction electrodes; setup and use of nerve stimulators and amplifiers; acquisition of low noise, small voltage CAP data and digital conversion; use of software for data analyses of CAP components; and tips for troubleshooting. © 2020 Wiley Periodicals LLC. Basic Protocol 1: Electrophysiology wiring and hardware setup Support Protocol 1: 3D printing an electrophysiology chamber Support Protocol 2: Building suction electrodes Basic Protocol 2: Sciatic nerve dissection and compound action potential recording Basic Protocol 3: Data export and analysis Support Protocol 3: Preparation of HEPES‐buffered physiologic solution

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“…274,275 Interestingly, focused ultrasound is also capable of inducing conduction block in peripheral nerves and is actively being explored as a potential treatment for pain and spasticity. 276–278 …”

Section: Future Interfaces: Novel Paradigmsmentioning

confidence: 99%

The Evolution of Neuroprosthetic Interfaces

Adewole¹,

Serruya

Harris

et al. 2016

Crit Rev Biomed Eng

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The ideal neuroprosthetic interface permits high-quality neural recording and stimulation of the nervous system while reliably providing clinical benefits over chronic periods. Although current technologies have made notable strides in this direction, significant improvements must be made to better achieve these design goals and satisfy clinical needs. This article provides an overview of the state of neuroprosthetic interfaces, starting with the design and placement of these interfaces before exploring the stimulation and recording platforms yielded from contemporary research. Finally, we outline emerging research trends in an effort to explore the potential next generation of neuroprosthetic interfaces.

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Nerve conduction block in diabetic rats using high-intensity focused ultrasound for analgesic applications

Cited by 33 publications

References 28 publications

Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review

Interfaces with the peripheral nervous system for the control of a neuroprosthetic limb: a review

Ex Vivo Whole Nerve Electrophysiology Setup, Action Potential Recording, and Data Analyses in a Rodent Model

The Evolution of Neuroprosthetic Interfaces

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