2016
DOI: 10.1038/srep36054
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Network Consistency Projection for Human miRNA-Disease Associations Inference

Abstract: Prediction and confirmation of the presence of disease-related miRNAs is beneficial to understand disease mechanisms at the miRNA level. However, the use of experimental verification to identify disease-related miRNAs is expensive and time-consuming. Effective computational approaches used to predict miRNA-disease associations are highly specific. In this study, we develop the Network Consistency Projection for miRNA-Disease Associations (NCPMDA) method to reveal the potential associations between miRNAs and d… Show more

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Cited by 94 publications
(55 citation statements)
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“…The broad target spectrum of a single miR makes it is difficult to predict the consequence of miR regulation on cellular processes unless miR-regulated gene and protein expression are considered. Systems biology approaches successfully map such interactome and miRNome data for the identification of regulatory pathways in disease (23)(24)(25)(26)(27)(28)(29)(30).…”
Section: Figure 2 Isolation Of Live Cd4 + Th Cell Subsets From Allermentioning
confidence: 99%
“…The broad target spectrum of a single miR makes it is difficult to predict the consequence of miR regulation on cellular processes unless miR-regulated gene and protein expression are considered. Systems biology approaches successfully map such interactome and miRNome data for the identification of regulatory pathways in disease (23)(24)(25)(26)(27)(28)(29)(30).…”
Section: Figure 2 Isolation Of Live Cd4 + Th Cell Subsets From Allermentioning
confidence: 99%
“…To quantify the predictive power of their network-based model, many studies use the Area Under the Curve of the Receiver Operating Characteristic (AUC-ROC), another frequently used method in validation problems [39,87,88]. The AUC-ROC is the plot between sensitivity and (1-specificity).…”
Section: Methodsmentioning
confidence: 99%
“…27 The data set is successfully applied to multiple methods. 80,[93][94][95] We use matrix SM to represent the adjacency matrix of miRNA, and SM(i, j) is the score of functional similarity score between miRNA i and miRNA j.…”
Section: Data Preparationmentioning
confidence: 99%