Neue Cardenolide aus<i>Convallaria majalis</i>

Kopp, B; Kubelka, W.

doi:10.1055/s-2007-971372

Cited by 32 publications

(12 citation statements)

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“…The cardenolides desglucocheirotoxin, strophanolloside, lokundjoside, convallatoxol and the bufadienolide proscillaridin A as well as the bufadienolide aglycons arenobufagin, resibufogenin, bufarenogin, bovogenin A, gamabufogenin, bufotaline and the cardenolide evomonoside, were isolated from Convallaria majalis L. toad venoms and Urginea species. Their chemical structures were elucidated by NMR spectroscopy and mass spectrometry (MS) as described in more detail previously .…”

Section: Methodsmentioning

confidence: 99%

Analysis of proliferation and apoptotic induction by 20 steroid glycosides in 143B osteosarcoma cells in vitro

et al. 2015

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Section: Methodsmentioning

confidence: 99%

Analysis of proliferation and apoptotic induction by 20 steroid glycosides in 143B osteosarcoma cells in vitro

et al. 2015

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“…When epinephrine and norepinephrine bind to membrane receptors, a chain reaction is initiated; the increased calcium level results in increased ionotropic capacity. 9 Convallaria have been used for centuries by herbalists in the treatment of certain cardiac dysfunctions like congestive heart failure and cardiomyopathy. Convallarin is effectively used as a cardiotonic and diuretic.…”

Section: Convallaria Majalismentioning

confidence: 99%

Herbal Remedies for Cardiovascular Diseases

Nath¹,

Anusree²,

Navis³

et al. 2020

IJPSRR

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Cardiovascular diseases are currently the leading cause of death in industrialized countries and include a broad range of diseases, including hypertension, hyperlipidemia, thromboembolism, coronary heart disease, heart failure, endocarditis, stroke, peripheral vascular disease and many other conditions. CVDs are the leading cause of death globally. The most opted treatment for CVDs remains conventional drug therapies for example diuretics, vasodilators, anticoagulants, anti-platelet agents and β-blockers. But still herbal medication are high in their value and this option is now becoming a world wide procedure in many disease treatments including heart diseases. In this review, few herbal medications with their action on the cardiovascular system has been enlisted and shows their use as a cardiovascular medicine. Compared with conventional medications, herbal medications do not require clinical studies before their marketing or formal approval from regulatory agencies, and for this reason their efficacy and safety are rarely proven

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“…Convallaria majalis contains at least around 40 cardiac glycosides (including convallarin, convallotoxin, convalloside, convallasaponin, cholestane glycoside, strophanthidin, cannogenol, sarmentogenin, dipindogenin and hydroxysarmentogenin). [16][17][18] The Convallaria plant transforms convalloside (the basic metabolic glycoside) into convallatoxin and other cardiac glycosides. 19 Convallatoxin affects vasoconstriction and vasodilation, 20 and cardiac stroke volume, pulse pressure and cAMP activity are all enhanced by Convallaria.…”

Section: Convallaria (Lily Of the Valley)mentioning

confidence: 99%

The Use of Convallaria and Crataegus in the Treatment of Cardiac Dysfunction

Stansbury¹,

Saunders²,

Winston³

et al. 2012

j restorat med

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Herbal medicines have been effectively used for the treatment of cardiovascular diseases for many years. Herbs such as Convallaria (Lily of the Valley) root and Crataegus (Hawthorne) have shown significant benefits as adjunctive or stand alone therapies for the treatment of cardiac disorders such as arrhythmia, mitral valve prolapse and shortness of breath. Convallaria has been used for the treatment of congestive heart failure and cardiomyopathy, whereas Crataegus contains flavonoids with anti-inflammatory, anti-oxidant and protective cardiac effects. Crataegus functions as a natural angiotensin converting enzyme inhibitor, and it is therefore beneficial for the treatment of hypertension. Convallaria and Crataegus have been used in combination with other herbal remedies such as Selenocereus (Night Blooming Cereus), Leonorus (Motherwort), Melissa (Lemon Balm), Lepidium (Maca), and Ginkgo (Ginkgo). Convallaria may interact with digoxin and should not be used during pregnancy, whereas Crataegus is a safe herb when used as indicated. Although accidental poisoning resulting from the ingestion of Convallaria has been reported, toxicity from this medicinal herb is rare because of its poor absorption and short half life. Studies have shown that at the appropriate doses, Convallaria and Crataegus are safe and effective alternative treatments for the management of cardiac dysfunction.

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Neue Cardenolide ausConvallaria majalis

Cited by 32 publications

References 1 publication

Analysis of proliferation and apoptotic induction by 20 steroid glycosides in 143B osteosarcoma cells in vitro

Analysis of proliferation and apoptotic induction by 20 steroid glycosides in 143B osteosarcoma cells in vitro

Herbal Remedies for Cardiovascular Diseases

The Use of Convallaria and Crataegus in the Treatment of Cardiac Dysfunction

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