Neural control of immune cell trafficking

Mueller, Scott N.

doi:10.1084/jem.20211604

Cited by 34 publications

(16 citation statements)

References 116 publications

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“…Both leukocyte-intrinsic and -extrinsic pathways are influenced by neural signals to direct migration. Investigation of the effects of neurotransmitters on leukocytes in the blood, in particular the catecholamines noradrenaline (also known as norepinephrine) and adrenaline (epinephrine), spans more than a century, providing clear evidence of their impact on systemic leukocyte trafficking [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that the enzyme choline acetyltransferase, which catalyzes the rate-limiting step of ACh production, is robustly induced in both CD4+ and CD8+ T cells during lymphocytic choriomeningitis virus infection in an IL-21-dependent manner. Deletion of choline acetyltransferase within the T cell compartment in mice ablated vasodilation in response to infection, impaired the migration of antiviral T cells into infected tissues, and ultimately compromised the control of chronic lymphocytic choriomeningitis virus infection [22,24].…”

Section: Discussionmentioning

confidence: 99%

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Sensitivity of peripheral blood lymphocytes to adrenaline and acetylcholine in patients with primary and recurrent posterior uveitis

Khramenko¹,

Velychko²,

Bogdanova³

et al. 2022

Oftalmol Zh

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Background:Posterior uveitis is a polyetiologic group of diseases with polymorphic clinical manifestations and a prolonged, chronic and recurrent course. In addition, it is commonly bilateral and often causes complications, loss of working capacity and early visual disability in young adults. It is an important task of current clinical ophthalmology to find biomarkers indicating the severity of inflammation and the likelihood of developing a recurrence of the initial process. Purpose: To determine the sensitivity of peripheral blood lymphocytes to adrenaline and acetylcholine in patients with primary and recurrent uveitis at different phases of the disease. Material and Methods: One hundred patients with idiopathic posterior uveitis were examined at different phases of the disease. The control group was composed of 16 healthy individuals of a similar age. The specific sensitivity of lymphocytes to neuromediators, adrenaline and acetylcholine (expression of T cell adrenergic and acetylcholine receptors) was assessed using our complex methodology (in conjunction with a parallel sampling method) for assessing the individual's sensitivity to medicaments (biological regulators) which has been developed at Immunology laboratory, Filatov Institute of Eye Disease and Tissue Therapy. The method involves obtaining lymphocytes from an individual, culturing lymphocytes with examined drugs immunohistochemically, and use of a peroxidase anti-peroxidase method with monoclonal T-cell antibodies. Results: Absolute and relative adrenoreceptor and acetylcholine receptor expression levels in patients with posterior uveitis were 1.8-2.0 times and 1.6-2.4 times, respectively, higher in patients with posterior uveitis compared to controls. Absolute adrenoreceptor and acetylcholine receptor expression values were 12.6% and 31.7%, respectively, higher in the recurrent process during active inflammation compared to the period of remission. However, in patients with posterior uveitis, adrenoreceptor and acetylcholine receptor expression values in the period of remission were still higher than normal values. The odds of an increased relative adrenoreceptor expression and the odds of an increased relative acetylcholine receptor expression on peripheral blood lymphocytes were 67.5-fold higher and 23.6-fold higher, respectively, among patients with posterior uveitis compared to controls. The correlation of adrenoreceptor expression and acetylcholine receptor expression with absolute counts of T cells and T helpers was stronger than the correlation with B cells, which reflects to a larger extent the association with the cellular immunity and to a lesser extent the association with the humoral immunity. There was a moderate correlation of adrenoreceptor expression and acetylcholine receptor expression with cell subsets of markers of early lymphocyte activation CD5, autoimmune aggression CD25, intercellular adhesion CD54 and apoptosis CD95 (Fas/APO-1). Conclusion:The adrenoreceptor expression and acetylcholine receptor expression on peripheral bl...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sensitivity of peripheral blood lymphocytes to adrenaline and acetylcholine in patients with primary and recurrent posterior uveitis

Khramenko¹,

Velychko²,

Bogdanova³

et al. 2022

Oftalmol Zh

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“…Actually, most tissues including lymphoid organs are innervated by autonomic (primarily adrenergic) and sensory nerves. Both adrenaline, and substance P (produced by adrenergic neurons), or the neuropeptide TAFA4 (produced by sensory neurons) control leukocyte trafficking and the migration of immune cells in tissues [reviewed in ( 76 )]. The above data and many others support and provide mechanistic explanations to the long known observation that stress may alter immune responses ( 77 ).…”

Section: Crosstalk Between the Two Systems Of Relationmentioning

confidence: 99%

The immune system as a system of relations

Daëron

2022

Front. Immunol.

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Progress in neuroimmunology established that the nervous and the immune systems are two functionally related physiological systems. Unique sensory and immune receptors enable them to control interactions of the organism with the inner and the outer worlds. Both systems undergo an experience-driven selection process during their ontogeny. They share the same mediators/neurotransmitters and use synapses for intercellular communication. They keep a memory of previous experiences. Immune cells can affect nervous cells, nervous cells can affect immune cells, and they regulate each other. I however argue that the two systems differ by three major points: 1) Unlike the nervous system, the immune system has a loose anatomical structure, in which molecular and cellular events mostly occur at random; 2) The immune system can respond to molecules of the living world whereas the nervous system can respond to phenomena of the physical world; 3) Responses of the immune system act both on the organism and on the stimulus that triggered the response, whereas responses of the nervous system act on the organism only. The nervous and the immune systems therefore appear as two complementary systems of relations that closely work together, and whose reactivities are well-suited to deal with physical and biological stimuli, respectively. Its ability both to adapt the organism to the living world and to adapt the living world to the organism endows the immune system with powerful adaptive properties that enable the organism to live in peace with itself and with other living beings, whether pathogens or commensals.

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“…In Crohn’s disease (CD), one of the inflammatory bowel diseases (IBDs), nutritional therapy with reduced enteric antigenic load is effective to induce remission ( 1 ), suggesting that modulation of luminal factors exert strong effects on functions of immune cells. Immune cell trafficking from the blood stream through the lymphatic organ to the lymphatics has also an essential function for immune responses, and most mature leukocytes spend much of their cellular lives trafficking around the body to identify and eradicate microorganisms and malignant cells ( 2 ). This trafficking system works systemically including gut-associated lymphoid tissue (GALT).…”

Section: Introductionmentioning

confidence: 99%

Modulation by luminal factors on the functions and migration of intestinal innate immunity

Higashiyama

Miura²,

Hokari³

2023

Front. Immunol.

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Luminal antigens, nutrients, metabolites from commensal bacteria, bile acids, or neuropeptides influence the function and trafficking of immune cells in the intestine. Among the immune cells in the gut, innate lymphoid cells, including macrophages, neutrophils, dendritic cells, mast cells, and innate lymphoid cells, play an important role for the maintenance of intestinal homeostasis through a rapid immune response to luminal pathogens. These innate cells are influenced by several luminal factors, possibly leading to dysregulated gut immunity and intestinal disorders such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and intestinal allergy. Luminal factors are sensed by distinct neuro-immune cell units, which also have a strong impact on immunoregulation of the gut. Immune cell trafficking from the blood stream through the lymphatic organ to lymphatics, an essential function for immune responses, is also modulated by luminal factors. This mini-review examines knowledge of luminal and neural factors that regulate and modulate response and migration of leukocytes including innate immune cells, some of which are clinically associated with pathological intestinal inflammation.

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Neural control of immune cell trafficking

Cited by 34 publications

References 116 publications

Sensitivity of peripheral blood lymphocytes to adrenaline and acetylcholine in patients with primary and recurrent posterior uveitis

Sensitivity of peripheral blood lymphocytes to adrenaline and acetylcholine in patients with primary and recurrent posterior uveitis

The immune system as a system of relations

Modulation by luminal factors on the functions and migration of intestinal innate immunity

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