Neural correlates of graphic cigarette warning labels predict smoking cessation relapse

MacKillop, James; Gray, Joshua C.; Hawkshead, Brittany E.; Murphy, Cara M.; Sweet, Lawrence H.

doi:10.1016/j.pscychresns.2017.02.005

Cited by 7 publications

(9 citation statements)

References 44 publications

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“…Data on striatal circuit function have shown their potential to predict relapse in smokers [19][20][21]. For instance, blunted brain responses of dorsal striatum and medial/dorsolateral prefrontal cortex (mPFC and dlPFC) to pleasant vs. cigarette-related stimuli predict relapse in smokers [21].…”

Section: Introductionmentioning

confidence: 99%

“…For instance, blunted brain responses of dorsal striatum and medial/dorsolateral prefrontal cortex (mPFC and dlPFC) to pleasant vs. cigarette-related stimuli predict relapse in smokers [21]. Further, brain responses in the ventromedial PFC to graphic warning labels, relative to a visual control image, predicted relapse in treatment-seeking nicotinedependent smokers [19]. However, functional magnetic resonance imaging (MRI) cannot identify the structural connections between those circuits.…”

Section: Introductionmentioning

confidence: 99%

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Striato-cortical tracts predict 12-h abstinence-induced lapse in smokers

Yuan

Zhao

et al. 2018

Neuropsychopharmacol

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Striatal circuit dysfunction is implicated in smoking behaviors and lapses during abstinence attempts. However, little is known about whether the structural connectivity of striatal tracts can be used to predict abstinence-induced craving and lapses. The tract strengths of striatal circuits were compared in 53 male nicotine-dependent cigarette smokers and 58 matched nonsmokers, using seed-based classification by diffusion tensor imaging (DTI) probabilistic tractography with 10 a priori target masks. A 12-h abstinence procedure was then employed, after which 31 individuals abstained and 22 lapsed. Linear regression and binary logistic regression was conducted to test whether the tract strength of frontostriatal circuits was associated with craving changes in abstainers and predicted lapse in smokers. Compared with nonsmokers, in the left hemisphere, smokers showed weaker tract strength in striatum-medial orbitofrontal cortex (mOFC), striatum-ventral lateral prefrontal cortex (vlPFC), striatum-inferior frontal gyrus (IFG) and striatum-posterior cingulate cortex (PCC) (Bonferroni corrected, p < 0.05/20 = 0.0025). In abstainers, the abstinence-induced increases in craving were associated with the tract strength of the left striatum-mOFC and striatum-vlPFC. The tract strength of left striatum-dorsolateral PFC (dlPFC) predicted lapse in smokers with an accuracy of 68.3%. These results provide system-level insights into the weaker tract strength of frontostriatal circuits in male smokers and their potential roles as neuroimaging markers for abstinence-induced craving and risk of lapse. Future studies in female smokers are needed to determine if this generalizes across genders.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Striato-cortical tracts predict 12-h abstinence-induced lapse in smokers

Yuan

Zhao

et al. 2018

Neuropsychopharmacol

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“…26,28 The finding that neural activity in subregions of the MPFC implicated in self-related processing and valuation is associated with subsequent sharing engagement brings together previously disconnected findings that highlight the importance of interpersonal communication about mass media campaigns, 8,9,59,60 and research showing that brain activity within the MPFC during message exposure is related to subsequent behavior change. [12][13][14][15]28,61 Prior neuroimaging studies have identified subregions of the MPFC that are preferentially engaged during various types of self-related tasks, including the retrieval of autobiographical memories 32,33 and engagement in explicit and implicit self-referential thoughts. 34−38 Recent research has also shown that brain activity in these same regions is implicated in intentions to share health news in young adults, 23,24 suggesting that self-relevance may be one important antecedent to decisions to share.…”

Section: Discussionmentioning

confidence: 99%

Adolescents’ Neural Response to Tobacco Prevention Messages and Sharing Engagement

Pei

Schmälzle

Kranzler

et al. 2019

American Journal of Preventive Medicine

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Interpersonal communication can reinforce media effects on health behavior. Recent studies have shown that brain activity in the medial prefrontal cortex during message exposure can predict message-consistent behavior change. Key next steps include examining the relationship between neural responses to ads and measures of interpersonal message retransmission that can be collected at scale. Methods: Neuroimaging, self-report, and automated linguistic measures were utilized to investigate the relationships between neural responses to tobacco prevention messages, sharing engagement, and smoking-relevant belief changes. Thirty-seven adolescent nonsmokers viewed 12 ads from the U.S. Food and Drug Administration's "The Real Cost" campaign during a functional magnetic resonance imaging scan session (2015−2016). Data were analyzed between 2016 and 2017. The extent that participants talked in detail about the main message of the ads, or sharing engagement, was measured through transcripts of participants' subsequent verbal descriptions using automated linguistic coding. Beliefs about the consequences of smoking were measured before and after the main experiment using surveys. Results: Increased brain activation in self-and value-related subregions of the medial prefrontal cortex during message exposure was associated with subsequent sharing engagement when participants verbally talked about the ads. In addition, sharing engagement was significantly associated with changes in participants' beliefs about the social consequences of smoking. Conclusions: Neural activity in self-and value-related subregions of the medial prefrontal cortex during exposure to "The Real Cost" campaign was associated with subsequent sharing engagement, which in turn was related to social belief change. These results provide new insights into the link between neurocognitive responses to ads, the content of interpersonal sharing, and downstream health-relevant outcomes. Supplement information: This article is part of a supplement entitled Fifth Anniversary Retrospective of "The Real Cost," the Food and Drug Administration's Historic Youth Smoking Prevention Media Campaign, which is sponsored by the U.S. Food and Drug Administration.

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“…Furthermore, the obtained results have shown, through the estimation of the investigated indexes (i.e., Effort Index), the occurrence of a peculiar neural activation in the prefrontal cortex in response to antismoking advertising. There have been many studies which have demonstrated that the average neural activity in the medial prefrontal cortex (MPFC) during messaging has been associated with future healthier behaviour change in individuals (e.g., for smoking reduction [ 97 ], physical activity [ 98 ]), as well as population measures of antismoking campaigns effectiveness (e.g., online click-through-rates [ 99 ] and calls to quit lines [ 100 ]). Given the multiple psychological functions supported by MPFC [ 101 ], examining the functional connectivity, specifically within the brain's value system can provide additional information about why and how certain types of messages, like graphic warning messages, exert their effects.…”

Section: Discussionmentioning

confidence: 99%

Neurophysiological Profile of Antismoking Campaigns

Modica

Rossi

Cartocci

et al. 2018

Computational Intelligence and Neuroscience

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Over the past few decades, antismoking public service announcements (PSAs) have been used by governments to promote healthy behaviours in citizens, for instance, against drinking before the drive and against smoke. Effectiveness of such PSAs has been suggested especially for young persons. By now, PSAs efficacy is still mainly assessed through traditional methods (questionnaires and metrics) and could be performed only after the PSAs broadcasting, leading to waste of economic resources and time in the case of Ineffective PSAs. One possible countermeasure to such ineffective use of PSAs could be promoted by the evaluation of the cerebral reaction to the PSA of particular segments of population (e.g., old, young, and heavy smokers). In addition, it is crucial to gather such cerebral activity in front of PSAs that have been assessed to be effective against smoke (Effective PSAs), comparing results to the cerebral reactions to PSAs that have been certified to be not effective (Ineffective PSAs). The eventual differences between the cerebral responses toward the two PSA groups will provide crucial information about the possible outcome of new PSAs before to its broadcasting. This study focused on adult population, by investigating the cerebral reaction to the vision of different PSA images, which have already been shown to be Effective and Ineffective for the promotion of an antismoking behaviour. Results showed how variables as gender and smoking habits can influence the perception of PSA images, and how different communication styles of the antismoking campaigns could facilitate the comprehension of PSA's message and then enhance the related impact.

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Neural correlates of graphic cigarette warning labels predict smoking cessation relapse

Cited by 7 publications

References 44 publications

Striato-cortical tracts predict 12-h abstinence-induced lapse in smokers

Striato-cortical tracts predict 12-h abstinence-induced lapse in smokers

Adolescents’ Neural Response to Tobacco Prevention Messages and Sharing Engagement

Neurophysiological Profile of Antismoking Campaigns

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