Neural correlates of impaired emotional discrimination in borderline personality disorder: An fMRI study

Guitart-Masip, Marc; Pascual, Juan Carlos; Carmona, Susanna; Hoekzema, Elseline; Bergé, Daniel; Pérez‐Solà, Víctor; Soler, Joaquim; Soliva, Joan Carles; Rovira, Mariana; Bulbena, Antoni; Vilarroya, Óscar

doi:10.1016/j.pnpbp.2009.08.022

Cited by 65 publications

(35 citation statements)

References 44 publications

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“…50 In contrast, increased activation of middle and inferior temporal areas has been described during tasks requiring emotional processing. 51 With regard to parietal regions, neuropsychologic studies have suggested visuospatial processing and learning deficits in patients with BPD, 52 possibly linked to an impaired engagement of prefrontal and posterior parietal attentional systems. Moreover, abnormal posterior and right hemisphere γ synchrony has been discussed as suggestive of a lack of sensory integration and attentional control in patients with BPD.…”

Section: Discussionmentioning

confidence: 99%

Aberrant connectivity of resting-state networks in borderline personality disorder

Wolf

Sambataro

Vasić

et al. 2011

jpn

109

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Background: Several functional neuroimaging studies have reported regionally abnormal activation of the frontal cortex in individuals with borderline personality disorder (BPD) during cognitive and affective task performance. However, little is known about neural function in individuals with BPD during the resting state. Using functional magnetic resonance imaging (fMRI), this study investigated the functional connectivity of prefrontal and limbic networks in patients with BPD. Methods: Between January 2009 and March 2010, we investigated patients with BPD according to DSM-IV criteria and healthy controls by means of resting-state fMRI. The data were analyzed using a spatial group independent component analysis, and random effects t tests were used to compare spatial components between groups (p < 0.005, uncorrected). Results: There were 17 women with BPD and 17 female healthy controls enrolled in this study. Within a network comprising cortical midline regions ("default mode network"), patients with BPD showed an increase in functional connectivity in the left frontopolar cortex (FPC) and the left insula, whereas decreased connectivity was found in the left cuneus. Within a network comprising predominantly right lateral prefrontal and bilateral parietal regions, patients with BPD showed decreased connectivity of the left inferior parietal lobule and the right middle temporal cortex compared with healthy controls. Two networks comprising lateral prefrontal and cingulate regions did not exhibit significant between-group differences. We found correlations between functional connectivity of the FPC and measures of impulsivity as well as between connectivity of the insula/cuneus and dissociation tension. Limitations: Co-occurrent axis I disorders and medication use in this sample of patients with BPD have to be considered as potential limitations. Conclusion: These data suggest that abnormal functional connectivity of temporally coherent resting-state networks may underlie certain symptom clusters in patients with BPD

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Section: Discussionmentioning

confidence: 99%

Aberrant connectivity of resting-state networks in borderline personality disorder

Wolf

Sambataro

Vasić

et al. 2011

jpn

109

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“…However, the direction of amygdala activity to unpleasant stimuli in BPD fMRI studies has been inconsistent and may be related to methodological differences 9 . Some early evidence showed an increase in amygdala activity to aversive stimuli 6,8,[41][42][43][44] whereas other studies have either not found a difference 45,46 or shown reduced activity 47 . More recently, a meta-analysis showed an overall reduction in amygdala activity to unpleasant stimuli 9 in line with our findings.…”

Section: Amygdalamentioning

confidence: 96%

Amygdala and dlPFC abnormalities, with aberrant connectivity and habituation in response to emotional stimuli in females with BPD

Dudás

Mole

Morris

et al. 2017

Journal of Affective Disorders

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dlPFC abnormalities, with aberrant connectivity and habituation in response to emotional stimuli in females with BPD, Journal of Affective Disorders, http://dx.doi.org/10.1016Disorders, http://dx.doi.org/10. /j.jad.2016 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Structurally, a significant 24% reduction of the left orbitofrontal and a 26% reduction of the right anterior cingulate cortex in BPD in comparison to controls has been observed (Tebartz van Elst et al, 2003). Other studies show volumetric reductions of the hippocampus, orbitofrontal cortex and amygdala in BPD (Domes et al, 2009;Lis et al, 2007) and ,, enhanced emotional-cue related activation in the amygdala (Donegan et al, 2003;Minzenberg et al, 2007), and middle and inferior temporal regions (Guitart-Masip et al, 2009) known to be involved in the processing of facial features carrying emotional content. Dyck et al (2009) suggest that a selective deficit of BPD patients in rapid and direct discrimination of negative and neutral emotional expressions may in large part underlie their difficulties in social interactions.…”

Section: Introductionmentioning

confidence: 95%

Functional and Structural MRI Studies on Impulsiveness: Attention-Deficit/Hyperactive Disorder and Borderline Personality Disorders

Archer¹,

Bright²

2012

Neuroimaging - Cognitive and Clinical Neuroscience

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Neural correlates of impaired emotional discrimination in borderline personality disorder: An fMRI study

Cited by 65 publications

References 44 publications

Aberrant connectivity of resting-state networks in borderline personality disorder

Aberrant connectivity of resting-state networks in borderline personality disorder

Amygdala and dlPFC abnormalities, with aberrant connectivity and habituation in response to emotional stimuli in females with BPD

Functional and Structural MRI Studies on Impulsiveness: Attention-Deficit/Hyperactive Disorder and Borderline Personality Disorders

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