Neural Mechanisms of Exercise: Effects on Gut Miccrobiota and Depression

Yuan, Ti‐Fei; Rocha, Nuno; Paes, Flávia; Arias-Carrión, Óscar; Machado, Sérgio; Filho, Alberto Souza de Sá

doi:10.2174/1871527315666151111124729

Cited by 11 publications

(8 citation statements)

References 38 publications

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“…Yuan et al found that physical exercise modulated different population of gut bacteria or rich diet, and alleviated gut syndromes to toxin intake. Gut microbiota could as well contribute to the beneficial effects of exercise on cognition and emotion, either directly through serotonin signaling or indirectly by modulating metabolism and exercise performance [69]. Similarly, we found that resistance training significantly reverted the level of trimethylamine-N-oxide, indicating that it has a regulatory effect on the intestinal flora metabolism in depressed rats.…”

Section: Intestinal Microbial Metabolismsupporting

confidence: 60%

Urine metabolomic responses to aerobic and resistance training in rats under chronic unpredictable mild stress

et al. 2020

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Background It is known that bioenergetics of aerobic and resistance exercise are not the same but both can effectively improve depression. However, it is not clear whether and how different types of exercise can influence depression through the same metabolic regulatory system. Metabolomics provides a way to study the correlation between metabolites and changes in exercise and/or diseases through the quantitative analysis of all metabolites in the organism. The objective of this study was to investigate the effects of aerobic and resistance training on urinary metabolites by metabolomics analysis in a rodent model of depression. Methods Male Sprague-Dawley rats were given chronic unpredictable mild stress (CUMS) for eight weeks. The validity of the modeling was assessed by behavioral indices. After four weeks of CUMS, the rats that developed depression were randomly divided into a depression control group, an aerobic training group and a resistance training group. There was also a normal control group. From week 5, the rats in the exercise groups were trained for 30 min per day, five days per week, for four weeks. The urine samples were collected pre and post the training program, and analyzed by proton nuclear magnetic resonance (1 H-NMR) spectroscopy. Results Both types of training improved depression-like behavior in CUMS rats. Compared with normal control, 21 potential biomarkers were identified in the urine of CUMS rats, mainly involved in energy, amino acids and intestinal microbial metabolic pathways. Common responses to the training were found in the two exercise groups that the levels of glutamine, acetone and creatine were significantly recalled (all P<0.05) Aerobic training also resulted in changes in pyruvate and trigonelline, while resistance training modified α-Oxoglutarate, citric acid, and trimethylamine oxide (all P<0.05).

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Section: Intestinal Microbial Metabolismsupporting

confidence: 60%

Urine metabolomic responses to aerobic and resistance training in rats under chronic unpredictable mild stress

et al. 2020

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“…It is generally recognized that traditional antidepressant therapies alleviate mental and brain abnormalities and treat depression. But the latest research has found that traditional therapies not only regulate the brain but also influence gut microbiota; their antidepressant effects are probably partly related with the regulation of the microbiota–gut–brain axis [ 16 , 149 , 150 ].…”

Section: The Latest Research Progress Of Depression: the Microbiotmentioning

confidence: 99%

“…Other therapies also changed the gut microbiota. Except the dietotherapy mentioned above, exercise therapy probably improves depression via the regulation of gut microbiota and the microbiota–gut–brain axis; a poor sedentary life style characterized by a lack of exercises increases the incidence of depression, while getting enough exercise alleviates depression [ 150 , 151 ].…”

Section: The Latest Research Progress Of Depression: the Microbiotmentioning

confidence: 99%

Recognizing Depression from the Microbiota–Gut–Brain Axis

Shen

et al. 2018

IJMS

250

155

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Major depression is one of the leading causes of disability, morbidity, and mortality worldwide. The brain–gut axis functions are disturbed, revealed by a dysfunction of the brain, immune system, endocrine system, and gut. Traditional depression treatments all target the brain, with different drugs and/or psychotherapy. Unfortunately, most of the patients have never received any treatment. Studies indicate that gut microbiota could be a direct cause for the disorder. Abnormal microbiota and the microbiota–gut–brain dysfunction may cause mental disorders, while correcting these disturbance could alleviate depression. Nowadays, the gut microbiota modulation has become a hot topic in treatment research of mental disorders. Depression is closely related with the health condition of the brain–gut axis, and maintaining/restoring the normal condition of gut microbiota helps in the prevention/therapy of mental disorders.

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“…Evidence suggests that aerobic exercise triggers diversity and abundance of genera from the Firmicutes phylum, with possible linkage with effects of exercise on the gut and brain [107]. What is undeniable is that synergic effects of microbiota with exercise on cognition and emotion play crucial roles in serotonin signaling and metabolism in general [285].…”

Section: Exercisementioning

confidence: 99%

Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications

et al. 2022

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The gut microbiota is a complex and dynamic ecosystem essential for the proper functioning of the organism, affecting the health and disease status of the individuals. There is continuous and bidirectional communication between gut microbiota and the host, conforming to a unique entity known as “holobiont”. Among these crosstalk mechanisms, the gut microbiota synthesizes a broad spectrum of bioactive compounds or metabolites which exert pleiotropic effects on the human organism. Many of these microbial metabolites can cross the blood–brain barrier (BBB) or have significant effects on the brain, playing a key role in the so-called microbiota-gut-brain axis. An altered Microbiota-Gut-Brain (MGB) axis is a major characteristic of many neuropsychiatric disorders, including major depressive disorder (MDD). Significative differences between gut eubiosis and dysbiosis in mental disorders like MDD with their different metabolite composition and concentrations are being discussed. In the present review, the main microbial metabolites (short-chain fatty acids -SCFAs-, bile acids, amino acids, tryptophan -trp- derivatives, and more), their signaling pathways and functions will be summarized to explain part of MDD pathophysiology. Conclusions from promising translational approaches related to microbial metabolome will be addressed in more depth to discuss their possible clinical value in the management of MDD patients.

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Neural Mechanisms of Exercise: Effects on Gut Miccrobiota and Depression

Cited by 11 publications

References 38 publications

Urine metabolomic responses to aerobic and resistance training in rats under chronic unpredictable mild stress

Urine metabolomic responses to aerobic and resistance training in rats under chronic unpredictable mild stress

Recognizing Depression from the Microbiota–Gut–Brain Axis

Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications

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