Neural Topography and Chronology of Memory Consolidation: A Review of Functional Inactivation Findings

Lorenzini, Carlo G Ambrogi; Baldi, Elisabetta; Bucherelli, Corrado; Sacchetti, Benedetto; Tassoni, Giovanna

doi:10.1006/nlme.1998.3865

Cited by 114 publications

(28 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In support of this hypothesis, training-driven, time-dependent changes in the topography of firing activity, possibly related to memory consolidation, have been described in rabbit avoidance learning by Freeman and Gabriel [115]. Similarly, Ambrogi-Lorenzini [116] reported that different brain structures are required during different temporal phases of memory formation in rat. Thus, as found in several temporal lobe-dependent memories, it is possible that the initial phase of consolidation is driven by modification of encoding circuits (e.g.…”

Section: Reconsolidation and The Passage Of Timementioning

confidence: 79%

Memory

Alberini

Milekic

Tronel

2006

Cell. Mol. Life Sci.

136

View full text Add to dashboard Cite

Memories become stabilized through a time-dependent process that requires gene expression and is commonly known as consolidation. During this time, memories are labile and can be disrupted by a number of interfering events, including electroconvulsive shock, trauma and other learning or the transient effect of drugs such as protein synthesis inhibitors. Once consolidated, memories are insensitive to these disruptions. However, they can again become fragile if recalled or reactivated. Reactivation creates another time-dependent process, known as reconsolidation, during which the memory is restabilized. Here we discuss some of the questions currently debated in the field of memory consolidation and reconsolidation, the molecular and anatomical requirements for both processes and, finally, their functional relationship.

show abstract

Section: Reconsolidation and The Passage Of Timementioning

confidence: 79%

Memory

Alberini

Milekic

Tronel

2006

Cell. Mol. Life Sci.

136

View full text Add to dashboard Cite

show abstract

“…As in our previous studies (Grosso et al, 2015b; Cambiaghi et al, 2016a), in order to reversibly block Te2 during memory consolidation processes, we administered Tetrodotoxin (TTX), a voltage-dependent sodium channels blocker. Unlike optogenetic manipulations or muscimol, TTX blocks neural activity for several hours (i.e., for at least 6–8 h; Zhuravin and Bures, 1991; Ambrogi Lorenzini et al, 1999; Martin and Ghez, 1999), and it is therefore suitable for interfering with long-term memory consolidation processes that require fast synaptic transmission for several hours and days (Ambrogi Lorenzini et al, 1999; Riedel et al, 1999; Sacchetti et al, 1999a, 2002; Lesburguères et al, 2011). Moreover, TTX has fully reversible effects and does not induce any permanent damage (Ambrogi Lorenzini et al, 1999; Sacchetti et al, 1999a, 2002).…”

Section: Resultsmentioning

confidence: 99%

“…Unlike optogenetic manipulations or muscimol, TTX blocks neural activity for several hours (i.e., for at least 6–8 h; Zhuravin and Bures, 1991; Ambrogi Lorenzini et al, 1999; Martin and Ghez, 1999), and it is therefore suitable for interfering with long-term memory consolidation processes that require fast synaptic transmission for several hours and days (Ambrogi Lorenzini et al, 1999; Riedel et al, 1999; Sacchetti et al, 1999a, 2002; Lesburguères et al, 2011). Moreover, TTX has fully reversible effects and does not induce any permanent damage (Ambrogi Lorenzini et al, 1999; Sacchetti et al, 1999a, 2002). To interfere with long-term system consolidation but not with the cellular consolidation mechanisms that are triggered immediately after training, TTX was administered 1 day after learning (Lesburguères et al, 2011; Cambiaghi et al, 2016b).…”

Section: Resultsmentioning

confidence: 99%

Reversible Inactivation of the Higher Order Auditory Cortex during Fear Memory Consolidation Prevents Memory-Related Activity in the Basolateral Amygdala during Remote Memory Retrieval

Cambiaghi

Renna

Milano

et al. 2017

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Recent findings have shown that the auditory cortex, and specifically the higher order Te2 area, is necessary for the consolidation of long-term fearful memories and that it interacts with the amygdala during the retrieval of long-term fearful memories. Here, we tested whether the reversible blockade of Te2 during memory consolidation may affect the activity changes occurring in the amygdala during the retrieval of fearful memories. To address this issue, we blocked Te2 in a reversible manner during memory consolidation processes. After 4 weeks, we assessed the activity of Te2 and individual nuclei of the amygdala during the retrieval of long-term memories. Rats in which Te2 was inactivated upon memory encoding showed a decreased freezing and failed to show Te2-to-basolateral amygdala (BLA) synchrony during memory retrieval. In addition, the expression of the immediate early gene zif268 in the lateral, basal and central amygdala nuclei did not show memory-related enhancement. As all sites were intact upon memory retrieval, we propose that the auditory cortex represents a key node in the consolidation of fear memories and it is essential for amygdala nuclei to support memory retrieval process.

show abstract

“…The passive avoidance learning task is particularly informative as both electro-physiologic and lesion studies map its neural basis, implicating the amygdala, orbitofrontal cortex, and striatum (17–21). In addition, a recent functional MRI study of the task has confirmed the importance of these regions in healthy human adults (22).…”

Section: Introductionmentioning

confidence: 99%

Disrupted Reinforcement Signaling in the Orbitofrontal Cortex and Caudate in Youths With Conduct Disorder or Oppositional Defiant Disorder and a High Level of Psychopathic Traits

Finger¹,

Marsh²,

Blair³

et al. 2011

AJP

226

204

View full text Add to dashboard Cite

OBJECTIVE Dysfunction in amygdala and orbital frontal cortex functioning has been reported in youths and adults with psychopathic traits. However, the specific nature of the computational irregularities within these brain structures remains poorly understood. The current study used the passive avoidance task to examine responsiveness of these systems to early stimulus-reinforcement exposure, when prediction errors are greatest and learning maximized, and to reward in youths with psychopathic traits and comparison youths. METHOD 30 youths (N=15 with conduct disorder or oppositional defiant disorder plus high psychopathic traits and N=15 comparison subjects) completed a 3.0 T fMRI scan while performing a passive avoidance learning task. RESULTS Relative to comparison youth, youths with conduct disorder or oppositional defiant disorder plus psychopathic traits showed reduced orbitofrontal cortex responsiveness both to early stimulus-reinforcement exposure and to rewards, as well as reduced caudate response to early stimulus-reinforcement exposure. Contrary to other predictions, however, there were no group differences in amygdala responsiveness specifically to these two task parameters. However, amygdala responsiveness throughout the task was reduced in the youths with conduct disorder or oppositional defiant disorder plus psychopathic traits. CONCLUSIONS This study demonstrates that youths with conduct disorder or oppositional defiant disorder plus psychopathic traits are marked by a compromised sensitivity to early reinforcement information in both orbitofrontal cortex and caudate and to reward outcome information within orbitofrontal cortex. They further suggest that the integrated functioning of the amygdala, caudate and orbitofrontal cortex may be disrupted in individuals with this disorder.

show abstract

Neural Topography and Chronology of Memory Consolidation: A Review of Functional Inactivation Findings

Cited by 114 publications

References 95 publications

Memory

Memory

Reversible Inactivation of the Higher Order Auditory Cortex during Fear Memory Consolidation Prevents Memory-Related Activity in the Basolateral Amygdala during Remote Memory Retrieval

Disrupted Reinforcement Signaling in the Orbitofrontal Cortex and Caudate in Youths With Conduct Disorder or Oppositional Defiant Disorder and a High Level of Psychopathic Traits

Contact Info

Product

Resources

About