Neuro-endocrine regulation of blood pressure

Chopra, Sandeep; Baby, Chris; Jacob, Jubbin Jagan

doi:10.4103/2230-8210.86860

Cited by 56 publications

(38 citation statements)

References 66 publications

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“…While big arteries like aorta play a role in conducting the blood and damping pulse pressure, smaller arteries contribute more to arterial resistance and hence blood pressure regulation [27].…”

Section: 2: Vasorelaxing Mechanismmentioning

confidence: 99%

Ferulic acid-4- O -sulfate rather than ferulic acid relaxes arteries and lowers blood pressure in mice

Rymenant

Camp

Pauwels

et al. 2017

The Journal of Nutritional Biochemistry

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Consumption of foods rich in ferulic acid (FA) such as wholegrain cereals, or FA precursors such as chlorogenic acids in coffee, is inversely correlated with risk of cardiovascular disease and type 2 diabetes. As a result of digestion and phase II metabolism in the gut and liver, FA is converted predominantly into ferulic acid-4-O-sulfate (FA-sul), an abundant plasma metabolite. Although FA-sul is the main metabolite, very little has been reported regarding its bioactivities. We have compared the ex vivo vasorelaxing effect of FA and FA-sul (10-3.10M) on isolated mouse arteries mounted in tissue myographs. FA-sul, but not FA, elicited a concentration-dependent vasorelaxation of saphenous and femoral arteries and aortae. The FA-sul-mediated vasorelaxation was blunted by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, a soluble guanylate cyclase (sGC) inhibitor. The role of sGC was confirmed in femoral arteries isolated from sGCα knockout mice. Furthermore, 4-aminopyridine, a specific inhibitor of voltage-dependent potassium channels, significantly decreased FA-sul-mediated effects. In anesthetized mice, intravenous injection of FA-sul decreased mean arterial pressure, whereas FA had no effect, confirming the results obtained ex vivo. FA-sul is probably one of the major metabolites accounting for the blood pressure-lowering effects associated with FA consumption.

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Section: 2: Vasorelaxing Mechanismmentioning

confidence: 99%

Ferulic acid-4- O -sulfate rather than ferulic acid relaxes arteries and lowers blood pressure in mice

Rymenant

Camp

Pauwels

et al. 2017

The Journal of Nutritional Biochemistry

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“…The kidneys monitor Na + levels and control blood pressure (BP) through the renin-angiotensin system [64]. Non-renal regulators of blood pressure include the cardiovascular, neural and endocrine systems [7]. Remarkably, during the past decade the skin has emerged as new regulator of blood pressure.…”

Section: Introductionmentioning

confidence: 99%

The role of macrophages in skin homeostasis

Yanez

Lacher

Vidyarthi

et al. 2017

Pflugers Arch - Eur J Physiol

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The skin and its appendages comprise the largest and fastest-growing organ in the body. It performs multiple tasks and maintains homeostatic control, including the regulation of body temperature, protection from desiccation and from pathogen invasion. The skin can perform its functions with the assistance of different immune cell populations. Monocyte-derived cells are imperative for the completion of these tasks. The comprehensive role of macrophages and Langerhans cells in establishing and maintaining skin homeostasis remains incompletely defined. However, over the past decade, innovations in mouse genetics have allowed for advancements in the field. In this review, we explore different homeostatic roles of macrophages and Langerhans cells, including wound repair, follicle regeneration, salt balance, and cancer regression and progression, in the skin. The understanding of the precise functions of myeloid-derived cells in the skin under basal conditions can help develop specific therapies that aid in skin and hair follicle regeneration and cutaneous cancer prevention.

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“…This is most likely due to the fact that blood pressure varies as a function of not only cardiac activity but also vascular changes due to local metabolic and myogenic factors (Chopra, Baby, & Jacob, 2011). Third it could be argued that individual differences in cardiac reactivity are not temporally stable.…”

mentioning

confidence: 99%

Exploring the possible mechanisms of blunted cardiac reactivity to acute psychological stress

Brindle

Whittaker

Bibbey

et al. 2017

International Journal of Psychophysiology

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Blunted cardiovascular reactivity to acute psychological stress has been linked to a range of adverse health and behavioral outcomes. However, the origins of blunted reactivity remain unclear. The current study aimed to explore the following possibilities: different appraisals of task stressfulness and/or difficulty, diminished task effort, or reduced physiological capacity to respond. Individuals characterized, via pre-screening, as blunted (n=17) or exaggerated (n=16) heart rate (HR) reactors to acute psychological stress (socially evaluative mental arithmetic) were exposed to a psychological stress, cold pressor and exercise tasks during a follow-up testing session while HR and blood pressure (BP) were measured. At follow-up, groups again mounted significantly different HR reactions to psychological stress, despite reporting similar levels of subjective stress and difficulty, and achieving similar tasks scores (measure of task effort) at both testing sessions. In response to the cold pressor and exercise blunted and exaggerated reactors displayed similar HR and BP responses. Results indicated that blunted reactors do not differ from exaggerated reactors on appraisals of task stressfulness or difficulty, or objective task effort, and do possess the physiological capacity to respond to other laboratory challenges. Other sources of blunted stress reactivity remain to be explored.

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Neuro-endocrine regulation of blood pressure

Cited by 56 publications

References 66 publications

Ferulic acid-4- O -sulfate rather than ferulic acid relaxes arteries and lowers blood pressure in mice

Ferulic acid-4- O -sulfate rather than ferulic acid relaxes arteries and lowers blood pressure in mice

The role of macrophages in skin homeostasis

Exploring the possible mechanisms of blunted cardiac reactivity to acute psychological stress

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