Neurobiological correlates of post-traumatic stress disorder: A focus on cerebellum role

Carletto, Sara; Borsato, Thomas

doi:10.1016/j.ejtd.2017.03.012

Cited by 16 publications

(14 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Taken together, these studies point toward a crucial role of the cerebellum in the psychopathology of PTSD (Carletto & Borsato, 2017), which is evident not only during exposure to trauma cues but also during resting state.…”

mentioning

confidence: 65%

The cerebellum after trauma: Resting‐state functional connectivity of the cerebellum in posttraumatic stress disorder and its dissociative subtype

Rabellino

Densmore

Théberge

et al. 2018

Human Brain Mapping

View full text Add to dashboard Cite

The cerebellum plays a key role not only in motor function but also in affect and cognition. Although several psychopathological disorders have been associated with overall cerebellar dysfunction, it remains unclear whether different regions of the cerebellum contribute uniquely to psychopathology. Accordingly, we compared seed-based resting-state functional connectivity of the anterior cerebellum (lobule IV-V), of the posterior cerebellum (Crus I), and of the anterior vermis across posttraumatic stress disorder (PTSD; n = 65), its dissociative subtype (PTSD + DS; n = 37), and non-trauma-exposed healthy controls (HC; n = 47). Here, we observed decreased functional connectivity of the anterior cerebellum and anterior vermis with brain regions involved in somatosensory processing, multisensory integration, and bodily self-consciousness (temporo-parietal junction, postcentral gyrus, and superior parietal lobule) in PTSD + DS as compared to PTSD and HC. Moreover, the PTSD + DS group showed increased functional connectivity of the posterior cerebellum with cortical areas related to emotion regulation (ventromedial prefrontal and orbito-frontal cortex, subgenual anterior cingulum) as compared to PTSD. By contrast, PTSD showed increased functional connectivity of the anterior cerebellum with cortical areas associated with visual processing (fusiform gyrus), interoceptive awareness (posterior insula), memory retrieval, and contextual processing (hippocampus) as compared to HC. Finally, we observed decreased functional connectivity between the posterior cerebellum and prefrontal regions involved in emotion regulation, in PTSD as compared to HC. These findings not only highlight the crucial role of each cerebellar region examined in the psychopathology of PTSD but also reveal unique alterations in functional connectivity distinguishing the dissociative subtype of PTSD versus PTSD.

show abstract

mentioning

confidence: 65%

The cerebellum after trauma: Resting‐state functional connectivity of the cerebellum in posttraumatic stress disorder and its dissociative subtype

Rabellino

Densmore

Théberge

et al. 2018

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…However, a bottom-up theory, involving the cerebellum, has been recently proposed in PTSD (S. Carletto & Borsato, 2017 ). The cerebellum is a structure implicated in fear emotional regulation (Schmahmann, 2010 ) and is strongly connected to the whole brain (Zhu, Yung, Kwok-Chong Chow, Chan, & Wang, 2006 ).…”

Section: Discussionmentioning

confidence: 99%

Involvement of the cerebellum in EMDR efficiency: a metabolic connectivity PET study in PTSD

Verger

Rousseau

Malbos

et al. 2020

European Journal of Psychotraumatology

View full text Add to dashboard Cite

Background: We recently reported an improvement of precuneus PET metabolism after EMDR therapy in military participants suffering from PTSD. Objective: The aim of the present study was to investigate the metabolic changes of precuneus connectivity in these participants after such treatment. Method: Fifteen participants with PTSD performed a brain 18F-FDG-PET sensitized by virtual reality exposure to war scenes, before and after EMDR treatment. Interregional correlation analysis was performed to study metabolic changes of precuneus connectivity through SPMT maps at whole-brain level (p < 0.005 for the voxel, p < 0.05 for the cluster). Results: A decrease of connectivity was observed after EMDR between the precuneus and two significant bilateral clusters of the cerebellum (bilateral Crus I and VI cerebellar lobules, Tmax voxel of 5.8 and 5.3, and cluster size of 343 and 314 voxels, respectively). Moreover, higher cerebellar metabolism before treatment was associated with reduced clinical PTSD scores after EMDR (p = 0.03). Conclusions: The posterior cerebellum and its metabolic connectivity with the precuneus are involved in the clinical efficiency of EMDR in PTSD.

show abstract

“…Altogether, these NSSs alterations highlight the role of the cerebellum. While the cerebellum has, until recently, not been considered as a key region in PTSD, there is growing evidence implicating the cerebellar region in the pathophysiology of PTSD (53,54). Convergent findings from neuroimaging and lesion studies showed that the cerebellum's role is not confined to motor function (55) but is also important in cognition and emotion (56,57).…”

Section: Discussionmentioning

confidence: 99%

Neurological Soft Signs and Post-Traumatic Stress Disorder: A Biomarker of Severity?

et al. 2020

View full text Add to dashboard Cite

Background: The psychophysiological changes for individual suffering from chronic post-traumatic stress disorder (PTSD) raise to the questions of how facilitate recovery and return to work. Negative alterations in neuro-cognition remain a complaint for patients and participate to long-term functional impairments. Neurological soft signs (NSSs) appear as a candidate for better understanding these complaints. They have been reported in several mental disorders. They are found in several behavioral and/or neurocognitive disorders and are taken into account by psychiatric rehabilitation programs to support recovery. As few studies evaluate NSSs in PTSD, our exploratory study aims to assess NSSs in chronic PTSD and their relationships with PTSD severity.Method: Twenty-two patients with a clinical diagnosis of chronic PTSD were evaluated in terms of PTSD severity (post-traumatic checklist scale, PCL5), NSSs (NSSs psychomotor skills scale, PASS), and well-being upon arrival to the hospital and compared with 15 healthy subjects. Statistical non-parametric analyses assessed the relationships between these variables.Results: PTSD subjects exhibited higher NSSs compared with healthy subjects. NSSs were positively associated with PTSD severity, with negative alterations in cognition and mood, and with impairment in well-being. They were higher in women compared with men. No impact of age was found. Three groups were identified based on the severity of the PTSD. Severe PTSD exhibited NSSs characterized by motor integration alterations.Conclusions: This pilot study suggests that NSSs might be a biomarker of PTSD severity. This proof of concept highlights the need for further research for better evaluating the clinical neuro-functional impairment. This will be helping for defining neurological remediation for promoting PTSD recovery.

show abstract

Neurobiological correlates of post-traumatic stress disorder: A focus on cerebellum role

Cited by 16 publications

References 59 publications

The cerebellum after trauma: Resting‐state functional connectivity of the cerebellum in posttraumatic stress disorder and its dissociative subtype

The cerebellum after trauma: Resting‐state functional connectivity of the cerebellum in posttraumatic stress disorder and its dissociative subtype

Involvement of the cerebellum in EMDR efficiency: a metabolic connectivity PET study in PTSD

Neurological Soft Signs and Post-Traumatic Stress Disorder: A Biomarker of Severity?

Contact Info

Product

Resources

About