Neurobrucellosis mimicking cerebral tumor: case report and literature review

Miguel, P. San; Fernández, G. Fernández; Vasallo, Francisco J.; Hortas, Mario; Lorenzo, José Ramón Fernández; Rodríguez, Irene; Ortiz-Rey, J.A.; Antón, Iosu

doi:10.1016/j.clineuro.2004.12.015

Cited by 28 publications

(18 citation statements)

References 15 publications

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“…Complications are often severe and life-threatening. Neurobrucellosis is a rare complication of brucellosis and often overlooked due to its non-specific manifestations and a broad spectrum of syndromes with similar characteristics (2). In 2008, the number of cases of brucellosis reported worldwide was >500,000, and 1.7 to 10% of patients with neurobrucellosis suffer morbidity (3).…”

Section: Discussionmentioning

confidence: 99%

Treatment of a subdural empyema complicated by intracerebral abscess due to Brucella infection

Zhang

Chen

Xie

et al. 2017

Braz J Med Biol Res

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A 55-year-old male presented with fever, stupor, aphasia, and left hemiparesis. A history of head trauma 3 months before was also reported. Cranial magnetic resonance imaging revealed slight contrast enhancement of lesions under the right frontal skull plate and right frontal lobe. Because of deterioration in nutritional status and intracranial hypertension, the patient was prepared for burr hole surgery. A subdural empyema (SDE) recurred after simple drainage. After detection of Brucella species in SDE, craniotomy combined with antibiotic treatment was undertaken. The patient received antibiotic therapy for 6 months (two doses of 2 g ceftriaxone, two doses of 100 mg doxycycline, and 700 mg rifapentine for 6 months) that resulted in complete cure of the infection. Thus, it was speculated that the preexisting subdural hematoma was formed after head trauma, which was followed by a hematogenous infection caused by Brucella species.

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Section: Discussionmentioning

confidence: 99%

Treatment of a subdural empyema complicated by intracerebral abscess due to Brucella infection

Zhang

Chen

Xie

et al. 2017

Braz J Med Biol Res

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“…It is endemic in many countries, including Turkey [1–3]. Brucella melitensis is known to be the most common etiological agent of human brucellosis in Turkey [4].…”

Section: Introductionmentioning

confidence: 99%

“…Neurobrucellosis is a rare, severe form of systemic infection with a broad range of clinical syndromes [3]. The broad spectrum of clinical involvement and nonspecific signs and symptoms may interfere with an early diagnosis of this disease [1]. Among its varied presentations, solitary intracranial masses are very uncommon in adults [1, 3].…”

Section: Introductionmentioning

confidence: 99%

“…The broad spectrum of clinical involvement and nonspecific signs and symptoms may interfere with an early diagnosis of this disease [1]. Among its varied presentations, solitary intracranial masses are very uncommon in adults [1, 3]. We present a rare case of neurobrucellosis with an isolated brain mass, mimicking a cerebral tumor in which the specific diagnosis was made via bacterial isolation in the blood and seroagglutination in the cerebrospinal fluid (CSF).…”

Section: Introductionmentioning

confidence: 99%

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Unusual presentation of neurobrucellosis: a solitary intracranial mass lesion mimicking a cerebral tumor

Erdem¹,

Namıduru²,

Karaoğlan³

et al. 2012

Journal of Infection and Chemotherapy

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Among the diverse presentations of neurobrucellosis, solitary intracranial mass lesions are extremely rare. To the best of our knowledge, we describe here the second case of neurobrucellosis mimicking a cerebral tumor caused by Brucella melitensis. The mass lesion was clinically and radiologically indistinguishable from a brain tumor. The diagnosis was established by isolating Brucella melitensis in a blood culture and a positive Wright’s agglutination test on the cerebrospinal fluid at 1:320 titers. Paraffin sections of the cerebral mass showed nongranulomatous encephalitis. We suggest that patients with an isolated intraparenchymal mass lesion with nongranulomatous encephalitis should also be studied for brucellosis in endemic areas.

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“…This presentation has been described, albeit rarely, in the imaging of neurobrucellosis. 13 There is variability in the literature regarding optimal antimicrobial regimen and appropriate duration of treatment of pediatric neurobrucellosis. Regimens must include antibiotics that penetrate the hematoencephalic barrier, maintain good concentrations in the CSF, and maintain intracellular action.…”

Section: Case Reportsmentioning

confidence: 99%

Unusual Presentations of Pediatric Neurobrucellosis

Budnik

Fuchs²,

Shelef³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Neurobrucellosis is an uncommon complication of pediatric brucellosis. Acute meningitis and encephalitis are the most common clinical manifestations, however symptoms may be protean and diagnosis requires a high index of suspicion in patients from endemic areas. Diagnosis is often based on neurological symptoms, serology, and suggestive brain imaging because cerebrospinal fluid culture yields are low. Two cases of pediatric neurobrucellosis with unusual clinical and radiologic findings are presented.

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Neurobrucellosis mimicking cerebral tumor: case report and literature review

Cited by 28 publications

References 15 publications

Treatment of a subdural empyema complicated by intracerebral abscess due to Brucella infection

Treatment of a subdural empyema complicated by intracerebral abscess due to Brucella infection

Unusual presentation of neurobrucellosis: a solitary intracranial mass lesion mimicking a cerebral tumor

Unusual Presentations of Pediatric Neurobrucellosis

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