Neurochemical Investigation on the Effects of a New Diphenylpiperazine Calcium Antagonist, KB-2796, on the Central Dopaminergic System of Rats.

Akira, Ikegami; Ozaki, Akio; Hara, Hideaki; Sukamoto, Takayuki; Yamashita, Atsushi; Ito, Keizo

doi:10.1254/jjp.58.399

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…However, in Japan, the sales of flunarizine have been discontinued for parkinsonism with antidopaminergic action occurred frequently. In contrast to flunarizine, since antidopaminergic effect of lomerizine is weak [17], we could not find reports the onset of parkinsonism in treatment with lomerizine. The efficacy of lomerizine 6 months after initiating treatment has been found to be 71% [18].…”

Section: Introductionmentioning

confidence: 63%

Influence of the Tohoku-Pacific Ocean Earthquake and Its Aftershocks on the Response to Prophylactic Therapy with Lomerizine in Patients with Migraine in Tokyo: A Retrospective Study

Ishii¹,

Katoh²,

Takagi³

et al. 2014

Eur Neurol

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Background: On March 11, 2011, the Tohoku-Pacific Ocean earthquake (magnitude 9.0) struck the eastern part of Japan. Despite being far from the epicenter of the catastrophic earthquake, the effects were strongly felt in Tokyo, and the aftershocks continued for several months. There are no reports regarding the influence of earthquakes on migraine medication. The aim of our study was to determine the impact of earthquakes on prophylactic therapy with lomerizine in patients with migraine in Tokyo. Methods: The study included patients with migraine who were admitted to outpatient clinics in Tokyo between January 2010 and July 2010 or between January 2011 and July 2011 and who were prescribed lomerizine prophylactically for headache by specialists. We investigated clinical factors from the medical records for 26 of these patients. Results: The study population included 10 patients in 2010 and 16 patients in 2011. The frequency of headaches was reduced to under 5 days/month during February in both the groups. Compared to 2010, the frequency of headaches significantly increased in 2011 in March, April and May. Conclusion: Patients with migraine were sensitive to exposure to the earthquake and their headaches worsened despite successful prophylactic treatment with lomerizine before the Tohoku-Pacific Ocean earthquake.

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Section: Introductionmentioning

confidence: 63%

Influence of the Tohoku-Pacific Ocean Earthquake and Its Aftershocks on the Response to Prophylactic Therapy with Lomerizine in Patients with Migraine in Tokyo: A Retrospective Study

Ishii¹,

Katoh²,

Takagi³

et al. 2014

Eur Neurol

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“…In addition, flunarizine reduces potassium-evoked increases in intracellular calcium in rat cerebral synaptosomes (Kobayahi et al 1992). Flunarizine has also been reported to cause a transient reduction in tyrosine hydroxylase immunoreactivity in nigrostriatal neurons (Takada et al 1992), and to inhibit [3H]-spiperone binding to striatal membranes in a concentration-dependent manner (Ikegami et al 1992).…”

Section: Calcium Channel Blockersmentioning

confidence: 99%

Drug-Induced Depression

Patten

Love

1994

Drug Safety

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According to the Diagnostic and Statistical Manual of Mental Disorders (DSM-III-R), drug-induced depression may be classified as an Organic Mood Syndrome, Depressed Type. Unfortunately, the DSM-III-R diagnostic criteria are not sufficiently precise for application in research, and studies of drug-induced depression have rarely utilised these criteria. Research concerned with drug-induced depression is characterised by a number of methodological complications. These include differing definitions of depression, including depression defined as a symptom, a syndrome, or by diagnostic criteria for a specific mental disorder. In addition, patients undergoing pharmacological treatments for medical illnesses are typically exposed to considerable psychosocial stress due to the suffering and disability associated with illness. These psychosocial factors may in themselves precipitate episodes of depression. Due to these complicating factors, sophisticated study designs are required to confirm an aetiological role for medications as risk factors for depression. Unfortunately, adequate studies have rarely been conducted, and much of the literature consists of case reports and clinical observations. Consequently, clinicians are frequently required to make clinical judgements about the aetiology of patients' depressive symptoms in the absence of definitive scientific information about the role of drugs. Nevertheless, a knowledge of the relevant literature will assist clinicians in making reasoned judgements about the aetiology, prevention and management of these disorders.

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Effects of verapamil on the release of different neurotransmitters

Sitges

Reyes

1995

J of Neuroscience Research

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The effect of verapamil on resting and depolarization-induced monoamine release was investigated in rat hippocampal synaptosomes prelabeled with [3H]-5-hydroxytryptamine (HT) or [3H]-norepinephrine (NE) and rat striatal synaptosomes prelabeled with [3H]-dopamine (DA). Verapamil (50 microM) completely abolishes high K(+)-induced [3H]-NE release, but paradoxically facilitates high K(+)-induced [3H]-5-HT and [3H]-DA release. All these high K(+)-evoked responses were Ca2+ dependent. Verapamil does not modify [3H]-NE baseline release, but increases dose dependently [3H]-5-HT and [3H]-DA baseline release. Verapamil (10 microM, for 5 min) increases endogenous DA release (70%) and endogenous 5-HT release (40%) independently on the presence of external Ca2+. The total amount of these monoamines (released plus retained by the preparation) and their metabolites (DOPAC and 5-HIAA) was similar in control and verapamil-treated synaptosomes. Verapamil displaces [3H]-spiroperidol specific binding (Ki of 2.4 x 10(-6) M) and [3H]-SCH-23390 specific binding (Ki of 9 x 10(-6) M) from striatal synaptosomal membranes, and [3H]-5-HT specific binding (Ki of 3 x 10(-5) M) from hippocampal synaptosomal membranes. It is concluded that in addition to the Ca2+ antagonistic properties of verapamil on the Ca(2+)-dependent, depolarization-induced release of some neurotransmitters [gamma aminobutyric acid (GABA and NE)], another mechanism probably mediated by presynaptic receptors underlies the effects of verapamil on DA and 5-HT release from discrete brain regions.

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Neurochemical Investigation on the Effects of a New Diphenylpiperazine Calcium Antagonist, KB-2796, on the Central Dopaminergic System of Rats.

Cited by 7 publications

References 17 publications

Influence of the Tohoku-Pacific Ocean Earthquake and Its Aftershocks on the Response to Prophylactic Therapy with Lomerizine in Patients with Migraine in Tokyo: A Retrospective Study

Influence of the Tohoku-Pacific Ocean Earthquake and Its Aftershocks on the Response to Prophylactic Therapy with Lomerizine in Patients with Migraine in Tokyo: A Retrospective Study

Drug-Induced Depression

Effects of verapamil on the release of different neurotransmitters

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